Guhong Injection Alleviates Cerebral Ischemia–Reperfusion Injury via the PKC/HIF-1α Pathway in Rats

Autor: Li Yu, Yangyang Zhang, Xixi Zhao, Haitong Wan, Yu He, Weifeng Jin

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Guhong injection (GHI) is a drug for ischemic stroke created by combining safflower, a traditional Chinese medicine, and aceglutamide, a Western medicine. In this study, we investigated the curative effect of GHI on cerebral ischemia–reperfusion (I

Externí odkaz: https://doaj.org/article/9b63f50d74464378a0bde17afea5cb2a

Nedd4-2–dependent Ubiquitination Potentiates the Inhibition of Human NHE3 by Cholera Toxin and Enteropathogenic Escherichia coli

Autor: C. Chris Yun, Yiran Han, Songbai Lin, Peijian He, Kayte A. Jenkin

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 695-716 (2022)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Diarrhea is one of the most common illnesses and is often caused by bacterial infection. Recently, we have shown that human Na+/H+ exchanger NHE3 (hNHE3), but not non-human NHE3s, interacts with the E3 ubiquitin ligase Nedd4-2. We h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d39e72e4258b61df22d22d51d780ec
https://doi.org/10.1016/j.jcmgh.2021.11.006

Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Autor: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)

Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020

Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators

Autor: Mingfei Ji, Jie Chen, Chuan Lv, Xinyi Li, Zongtao Chai, Jun Pu, Yuran Qiu, Duan Ni, Jian Zhang, Yuanhao Wang, Shaoyong Lu

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3433-3446 (2021)

RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for ∼19% of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301d6dec04ce4d283571a3cfb861136b
http://europepmc.org/articles/PMC8642438

Phosphorylation regulates cullin-based ubiquitination in tumorigenesis

Autor: Meidan Ying, Xuejing Shao, Hong Zhu, Ji Cao, Bo Yang, Yifan Chen, Qiaojun He

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 309-321 (2021)
Acta Pharmaceutica Sinica. B

Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and degradation, and can be targeted for disease treatment when the abnormal expression of substrates involves pathologic processes. Phosphorylation, either of subst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27b7f488f3a53677836e1b8e5b2722d
https://doi.org/10.1016/j.apsb.2020.09.007