Neomenthol prevents the proliferation of skin cancer cells by restraining tubulin polymerization and hyaluronidase activity

Autor: Kaneez Fatima, Abha Meena, Suaib Luqman, Nusrat Masood, Zahoor Ahmad Wani

Publikováno v: Journal of Advanced Research

Graphical abstract
Introduction Neomenthol, a cyclic monoterpenoid, is a stereoisomer of menthol present in the essential oil of Mentha spp. It is used in food as a flavoring agent, in cosmetics and medicines because of its cooling effects. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7618e7dc6e2d535e1930d5f8c2bf7d7e
https://doi.org/10.1016/j.jare.2021.06.003

Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver

Autor: Zhen-Ping Zhu, Ning Zhao, Cui-Li Zhang, Min-Jie Guan, Tao Zeng, Rui Yang, Li-Hua Yu, Keqin Xie, Mo Xiao, Xiulan Zhao

Publikováno v: Redox Biology, Vol 14, Iss, Pp 295-304 (2018)
Redox Biology

Protein kinase B (PKB/Akt) plays important roles in the regulation of lipid homeostasis, and impairment of Akt activity has been demonstrated to be involved in the development of non-alcoholic fatty liver disease (NAFLD). Previous studies suggest tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a771fdbd1d49b43ccdf431680e07a30
http://www.sciencedirect.com/science/article/pii/S2213231717306754

Insights into forsythia honeysuckle (Lianhuaqingwen) capsules: A Chinese herbal medicine repurposed for COVID-19 pandemic

Autor: Hui Nan, Xiaodong Ren, Pengcheng Yu, Hong Liu, Qiao Guaiping, Wenqiang Cao, Liu Yuzhi, Ju Xingke, Li Han, Jia Minyi, Lei Tian, Li Juan, Liang Chengyuan

Publikováno v: Phytomedicine Plus
Phytomedicine Plus, Vol 1, Iss 2, Pp 100027-(2021)

Highlights • The present review summarizes the plausible molecular mechanism of specific LH capsules in the control of SARS-COV-2 infection and the inhibition of cytokine storms caused by IL-6. • Preclinical and clinical trials of LH capsules in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed6ee319ef2e397034c14aa22649908
https://doi.org/10.1016/j.phyplu.2021.100027

Glutamate transporter-dependent mTOR phosphorylation in Müller glia cells

Autor: Arturo Ortega, Zila Martínez-Lozada, Ana María López-Colomé, Edith López, Alain M. Guillem

Publikováno v: ASN NEURO
ASN Neuro, Vol 4 (2012)
Scopus-Elsevier

Glu (glutamate), the excitatory transmitter at the main signalling pathway in the retina, is critically involved in changes in the protein repertoire through the activation of signalling cascades, which regulate protein synthesis at transcriptional a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1fdab5351056ddd73d447a82f073009
http://europepmc.org/articles/PMC3420017

Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation.

Autor: Luo K; State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.; Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China., Huang W; State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.; Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China., Qiao L; State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.; Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China., Zhang X; National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China., Yan D; School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Ning Z; State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.; Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China., Ma C; National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China., Dang H; National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China., Wang D; School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Guo H; National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China., Xie L; State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.; Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China.; National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China., Cheng J; State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.; Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China.; National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, China.; School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Publikováno v: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2022 May; Vol. 12 (5), pp. 2239-2251. Date of Electronic Publication: 2021 Nov 18.