Zobrazeno 1 - 10 of 326 pro vyhledávání: '"PK Maini"'
1
Quiescence as a mechanism for cyclical hypoxia and acidosis
Autor: K. Smallbone, DJ Gavaghan, PK Maini, JM Brady
Publikováno v: JOURNAL OF MATHEMATICAL BIOLOGY. 55(5)
Tumour tissue characteristically experiences fluctuations in substrate supply. This unstable microenvironment drives constitutive metabolic changes within cellular populations and, ultimately, leads to a more aggressive phenotype. Previously, variati
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http://ora.ox.ac.uk/objects/uuid:4ecee97d-a1cb-4974-bb9a-134b3d2bffd5
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2
Metabolic changes during carcinogenesis: Potential impact on invasiveness
Autor: K. Smallbone, RA Gatenby, RJ Gillies, PK Maini, DJ Gavaghan
Publikováno v: JOURNAL OF THEORETICAL BIOLOGY. 244(4)
Successful adaptation to varying microenvironmental constraints plays a crucial role during carcinogenesis. We develop a hybrid cellular automation approach to investigate the cell-microenvironmental interactions that mediate somatic evolution of can
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http://ora.ox.ac.uk/objects/uuid:8b9234cc-0a21-4e23-b197-aece7057509f
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3
Biomathematical modelling II − Preface
Autor: P. Kohl, A. Garny, PK Maini, DJ Gavaghan
Publikováno v: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A−MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. 364(1843)
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http://ora.ox.ac.uk/objects/uuid:8d7c53e8-f104-49be-8f50-6601f4d0704e
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4
Mathematical models in physiology
Autor: DJ Gavaghan, A. Garny, PK Maini, P. Kohl
Publikováno v: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A−MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. 364(1842)
Computational modelling of biological processes and systems has witnessed a remarkable development in recent years. The search-term (modelling OR modeling) yields over 58 000 entries in PubMed. with more than 34 000 since the year 2000: thus, almost
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http://ora.ox.ac.uk/objects/uuid:cd678ac0-a80a-469e-8682-aafd83be0b08
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5
role of acidity in solid tumour growth and invasion
Autor: K. Smallbone, DJ Gavaghan, RA Gatenby, PK Maini
Publikováno v: Journal of theoretical biology. 235(4)
Acidic pH is a common characteristic of human tumours. It has a significant impact on tumour progression and response to therapies. In this paper, we develop a simple model of three-dimensional tumour growth to examine the role of acidosis in the int
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http://ora.ox.ac.uk/objects/uuid:311e7863-5e92-45b9-b108-08010d4d8916
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6
Modelling rain forest diversity: The role of competition
Autor: CJ Bampfylde, ND Brown, DJ Gavaghan, PK Maini
Publikováno v: Ecological Modelling. 188(2)
Rain forests exhibit enormous species diversity, but the mechanisms for establishing and maintaining such diversity are unknown. Models involving both exploitative and pre-emptive competition have been proposed. We examine two of these models mathema
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http://ora.ox.ac.uk/objects/uuid:d8b015fb-c56e-4157-a40b-2227bf752057
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7
cell cycle model for somitogenesis: Mathematical formulation and numerical simulation
Autor: JR Collier, D. McInerney, S. Schnell, PK Maini, DJ Gavaghan, P. Houston, CD Stern
Publikováno v: Journal of theoretical biology. 207(3)
After many years of research, the mechanisms that generate a periodic pattern of repeated elements (somites) along the length of the embryonic body axis is still one of the major unresolved problems in developmental biology. Here we present a mathema
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http://ora.ox.ac.uk/objects/uuid:5e26df71-cf05-4b72-99e0-8ecd84c82848
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8
Mathematical modelling of ethanol metabolism in normal subjects and chronic alcohol misusers
Autor: Gd, Smith, Lj, Shaw, Pk, Maini, Roberta J Ward, Tj, Peters, Jd, Murray
Publikováno v: Europe PubMed Central
The time course of ethanol disappearance from the blood has been examined in normal males and females and in alcohol misusers. Blood alcohol estimations were made over a period of 3 hr, following an oral dose of ethanol (0.8 g/kg body weight) adminis
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http://europepmc.org/abstract/med/8471084
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9
Akademický článek
Characterising Cancer Cell Responses to Cyclic Hypoxia Using Mathematical Modelling.
Autor: Celora GL; Department of Mathematics, University College London, Gordon Street, London, 100190, UK. g.celora@ucl.ac.uk., Nixson R; Mathematical Institute, University of Oxford, Andrew Wiles Building, Woodstock Rd, Oxford, OX2 6GG, UK., Pitt-Francis JM; Department of Computer Science, University of Oxford, Parks Rd, Oxford, OX1 3QD, UK., Maini PK; Mathematical Institute, University of Oxford, Andrew Wiles Building, Woodstock Rd, Oxford, OX2 6GG, UK., Byrne HM; Mathematical Institute, University of Oxford, Andrew Wiles Building, Woodstock Rd, Oxford, OX2 6GG, UK.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Publikováno v: Bulletin of mathematical biology [Bull Math Biol] 2024 Nov 06; Vol. 86 (12), pp. 145. Date of Electronic Publication: 2024 Nov 06.
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10
Akademický článek
A First-Passage Model of Intravitreal Drug Delivery and Residence Time-Influence of Ocular Geometry, Individual Variability, and Injection Location.
Autor: Lamirande P; Wolfson Centre for Mathematical Biology, Mathematical Institute, Andrew Wiles Building, University of Oxford, Oxford, United Kingdom., Gaffney EA; Wolfson Centre for Mathematical Biology, Mathematical Institute, Andrew Wiles Building, University of Oxford, Oxford, United Kingdom., Gertz M; Pharmaceutical Sciences, Roche Innovation Center Basel, Roche Pharma Research and Early Development, Basel, Switzerland., Maini PK; Wolfson Centre for Mathematical Biology, Mathematical Institute, Andrew Wiles Building, University of Oxford, Oxford, United Kingdom., Crawshaw JR; Wolfson Centre for Mathematical Biology, Mathematical Institute, Andrew Wiles Building, University of Oxford, Oxford, United Kingdom.; School of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia., Caruso A; Pharmaceutical Sciences, Roche Innovation Center Basel, Roche Pharma Research and Early Development, Basel, Switzerland.
Publikováno v: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2024 Oct 01; Vol. 65 (12), pp. 21.
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