Zobrazeno 1 - 10
of 36
pro vyhledávání: '"PK/PD relationships"'
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Within a few years after the first successful clinical use of penicillin, investigations were conducted in animal infection models to explore a range of factors that were considered likely to influence the antibacterial response to the drug. Those st
Externí odkaz:
https://doaj.org/article/03ac342ee4e246c3954b8a7d396a88b6
Akademický článek
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Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 9, Iss 3, Pp 137-145 (2014)
The work aims to investigate the in vitro release, pharmacokinetics (PK), pharmacodynamics (PD) and PK–PD relationships of Salvianolic Acid B micro-porous osmotic pump pellets (SalB-MPOPs) in angina pectoris New Zealand White (NZW) rabbits, compare
Externí odkaz:
https://doaj.org/article/2e85f3aec6b84605b046ecdf7c7eba56
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Within a few years after the first successful clinical use of penicillin, investigations were conducted in animal infection models to explore a range of factors that were considered likely to influence the antibacterial response to the drug. Those st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aace35ff1d7d5c51737a1393523b1b7
https://www.frontiersin.org/articles/10.3389/fphar.2021.770518/full
https://www.frontiersin.org/articles/10.3389/fphar.2021.770518/full
Autor:
J R, Azanza Perea
Publikováno v:
Revista Española de Quimioterapia
In the past, the dose of an antibiotic was chosen, always from among those that were well tolerated, by considering those with the ability to exceed the MIC of bacteria in plasma. This approach, which has still not widely changed, is contrasted with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7df299e07b43adf111d773c5d94a1485
https://pubmed.ncbi.nlm.nih.gov/31475808
https://pubmed.ncbi.nlm.nih.gov/31475808
Publikováno v:
Revista Española de Quimioterapia
Ceftobiprole shows many similar pharmacokinetic properties to other cephalosporins, except for not being orally bioactive, and that it is administered by IV infusion as the prodrug ceftobiprole medocaril, which is subsequently hydrolyzed in the blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4f669e9e83541a3af3c769f4f2c3245
https://pubmed.ncbi.nlm.nih.gov/31364336
https://pubmed.ncbi.nlm.nih.gov/31364336
Akademický článek
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Publikováno v:
British journal of clinical pharmacology. 81(1)
Intrathecal baclofen (ITB) has proven to be an effective and safe treatment for severe spasticity. However, although ITB is used extensively, clinical decisions are based on very scarce pharmacokinetic-pharmacodynamic (PKPD) data. The aim of this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e63d26d28903b08eda118ffaa0206bcf
https://pubmed.ncbi.nlm.nih.gov/27099877
https://pubmed.ncbi.nlm.nih.gov/27099877
Autor:
Guan, Zheng, Klumpers, Linda E., Oyetayo, Olubukayo‐Opeyemi, Heuberger, Jules, van Gerven, Joop M. A., Stevens, Jasper
The severe psychiatric side effects of cannabinoid receptor type 1 (CB1 ) antagonists hampered their wide development but this might be overcome by careful management of drug development with pharmacokinetic/pharmacodynamic (PK/PD) analyses. PK/PD mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47cb1d7b3f55626198809b8c1265c584
https://europepmc.org/articles/PMC4799916/
https://europepmc.org/articles/PMC4799916/
Autor:
Dong, Jennifer Q, Rossulek, Michelle, Somayaji, Veena R, Baltrukonis, Daniel, Liang, Yali, Hudson, Krischan, Hernandez-Illas, Martha, Calle, Roberto A
The aim of the present study was to evaluate the pharmacokinetics/pharmacodynamics (PK/PD), safety and tolerability of single intravenous (IV) doses of PF-05231023, a long acting fibroblast growth factor 21 (FGF21) analogue being developed for the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bc4f7c85b808c34f05179a25b3454e87
https://europepmc.org/articles/PMC4631178/
https://europepmc.org/articles/PMC4631178/