Zobrazeno 1 - 10 of 72 pro vyhledávání: '"PK, pharmacokinetics"'
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Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China
Autor: Shengtao Yuan, Han Luwei, Dezhen Peng, Zhiqiang Wang, Hongzhi Du, Li Sun, Zhang Xian, Zhao Liwen, Danyu Du, Ligong Lu, Meixiao Zhan, Zhibo Zhang, Yong Li
Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1526-1540 (2021)
Acta Pharmaceutica Sinica. B
Acute myeloid leukaemia (AML) is the most common form of acute leukaemia in adults, with increasing incidence with age and a generally poor prognosis. Almost 20% of AML patients express mutant isocitrate dehydrogenase 2 (mIDH2), which leads to the ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1989ebe7a9db18d2c8b52de1673685c1
http://www.sciencedirect.com/science/article/pii/S2211383521000769
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3
Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines
Autor: Yi Guo, Mingshi Yang, Li Zhang, Changzhi Shi, Dongmei Cun, Hriday Bera
Publikováno v: Acta Pharmaceutica Sinica. B
Guo, Y, Bera, H, Shi, C, Zhang, L, Cun, D & Yang, M 2021, ' Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines ', Acta Pharmaceutica Sinica B, vol. 11, no. 8, pp. 2565-2584 . https://doi.org/10.1016/j.apsb.2021.05.015
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2565-2584 (2021)
Pulmonary administration route has been extensively exploited for the treatment of local lung diseases such as asthma, chronic obstructive pulmonary diseases and respiratory infections, and systemic diseases such as diabetes. Most inhaled medicines c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ad93be5bd1dd39fb79dc4d37488c35
http://europepmc.org/articles/PMC8424368
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4
Deimmunization of protein therapeutics – Recent advances in experimental and computational epitope prediction and deletion
Autor: Martin J. Loessner, Mathias Schmelcher, Noël Stierlin, Léa V. Zinsli
Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 315-329 (2021)
Computational and Structural Biotechnology Journal, 19
Biotherapeutics, and antimicrobial proteins in particular, are of increasing interest for human medicine. An important challenge in the development of such therapeutics is their potential immunogenicity, which can induce production of anti-drug-antib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc6eb34d6710e1da9ae4b3df006a799
https://doi.org/10.1016/j.csbj.2020.12.024
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5
Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy
Autor: Zhuowei Liu, Yuxi Wang, Chengjian Zhao, Yang Zhang, Manyu Zhao, Jinliang Yang, Yuqin Yao, Peng Li, Chen Zhengxia, Xiaoxin Chen, Chaofeng Long
Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1453-1475 (2020)
Angiokinases, such as vascular endothelial-, fibroblast- and platelet-derived growth factor receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti-angiogenesis therapy using multi-angiokinase inhibitor has achieved great
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6380c470a4be26e380966eab21f579
http://europepmc.org/articles/PMC7488503
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Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
Autor: Chunlin Zhuang, Fen-Er Chen, Ge Meng, KaiJun Jin, Erik De Clercq, Christophe Pannecouque, Minjie Liu
Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 2, Pp 344-357 (2020)
Acta Pharmaceutica Sinica. B
In order to improve the positional adaptability of our previously reported naphthyl diaryltriazines (NP-DATAs), synthesis of a series of novel biphenyl-substituted diaryltriazines (BP-DATAs) with a flexible side chain attached at the C-6 position is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669bcf19e6301aee51c948cba93b6a27
http://www.sciencedirect.com/science/article/pii/S2211383519301832
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7
The amyloid-β1-42-oligomer interacting peptide D-AIP possesses favorable biostability, pharmacokinetics, and brain region distribution
Autor: Adeola Shobo, Nicholas James, Daniel Dai, Alexander Röntgen, Corbin Black, Jean-Robert Kwizera, Mark A. Hancock, Khanh Huy Bui, Gerhard Multhaup
Publikováno v: The Journal of Biological Chemistry
We have previously developed a unique 8-amino acid Aβ42 oligomer-Interacting Peptide (AIP) as a novel anti-amyloid strategy for the treatment of Alzheimer's disease. Our lead candidate has successfully progressed from test tubes (i.e., in vitro char
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29a2223836effe65f042554ddc2330d
https://www.repository.cam.ac.uk/handle/1810/334182
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The combined effect of permeation enhancement and proteolysis inhibition on the systemic exposure of orally administrated peptides: Salcaprozate sodium, soybean trypsin inhibitor, and teriparatide study in pigs
Autor: Hillel Galitzer, Constantin Itin, William D. Fraser, Jonathan Tang, Gregory Burshtein, Phillip Schwartz
Publikováno v: International Journal of Pharmaceutics: X, Vol 3, Iss, Pp 100097-(2021)
International Journal of Pharmaceutics: X
Oral delivery of peptides and proteins is hindered by their rapid proteolysis in the gastrointestinal tract and their inability to permeate biological membranes. Various drug delivery approaches are being investigated and implemented to overcome thes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d2bd80762af53fd310511b4c6664b0
http://www.sciencedirect.com/science/article/pii/S2590156721000268
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9
Halobetasol propionate lotion 0.05% in patients 12 to 16 years 11 months of age with plaque psoriasis: Results of an open-label study evaluating adrenal suppression potential
Autor: Tien Nguyen, Andrea Nguyen, Vivian Laquer, Nicholas Squittieri
Publikováno v: JAAD International
JAAD International, Vol 6, Iss, Pp 13-19 (2022)
Background: The effects of halobetasol propionate (HBP) lotion 0.05% on the hypothalamic-pituitary-adrenal (HPA) axis have not been previously evaluated in adolescents. Objective: To examine the effect of HBP on HPA axis suppression in patients aged
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b54bac107c6d89ed7973f987bbb9a7
https://pubmed.ncbi.nlm.nih.gov/34870246
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Pharmacometric characterization of entero-hepatic circulation processes of orally administered formulations of amiodarone under complex binding kinetics
Autor: Karine Rodríguez-Fernández, Elena Gras-Colomer, Mónica Climente-Martí, Victor Mangas-Sanjuán, Matilde Merino-Sanjuán
Publikováno v: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
r-FISABIO. Repositorio Institucional de Producción Científica
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AIMS: The aims of this work are (i) to characterize the absorption properties of orally administered formulations at different dose levels, and (ii) to evaluate the impact of entero-hepatic circulation on the time-course of amiodarone (AM) in rats in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e3a76cf0ad7ec14d2124be96a6c0e3
https://doi.org/10.1016/j.ejps.2022.106198
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