Výsledky vyhledávání

Amino acid 489 is encoded by a mutational 'hot spot' on the beta 3 integrin chain: the CA/TU human platelet alloantigen system

Autor: R Wang, JG McFarland, R Kekomaki, PJ Newman

Publikováno v: Blood. 82:3386-3391

A new platelet alloantigen, termed CA, has recently been implicated in a case of neonatal alloimmune thrombocytopenia (NATP) in a Filipino family in Canada. Maternal anti-CA serum reacted with glycoprotein (GP) IIIa and maintained its reactivity afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e8650c6b84f03fd68d0e2eb1d3f9dce
https://doi.org/10.1182/blood.v82.11.3386.bloodjournal82113386

Zobrazit plný text záznamu

Neonatal alloimmune thrombocytopenia due to a new platelet-specific alloantibody

Autor: JG McFarland, V Blanchette, J Collins, PJ Newman, R Wang, RH Aster

Publikováno v: Blood. 81:3318-3323

An infant with severe neonatal alloimmune thrombocytopenia is described in whom an antibody directed at a new platelet-specific alloantigen, Ca (HPA-6b), is implicated. The new alloantigen is of low frequency in the population and was localized to pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15114b4b0d4e9a52b5e2df0a4077b93d
https://doi.org/10.1182/blood.v81.12.3318.bloodjournal81123318

Zobrazit plný text záznamu

Further characterization of the loop structure of platelet glycoprotein IIIa: partial mapping of functionally significant glycoprotein IIIa epitopes

Autor: Lisa K. Jennings, W C Kouns, PJ Newman, CD Wall, C F Fox, Jerome M. Seyer, AA Miller, KJ Puckett

Publikováno v: Blood. 78:3215-3223

Glycoprotein (GP) IIb-IIIa serves as the platelet fibrinogen receptor. Studies of the tertiary structure of GPIIIa have shown that the protein has a large loop structure of at least 325 amino acids in length. To further characterize this loop structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4bb39c678652857f4ab538a9043a492
https://doi.org/10.1182/blood.v78.12.3215.bloodjournal78123215

Zobrazit plný text záznamu

Prenatal diagnosis of neonatal alloimmune thrombocytopenia using allele- specific oligonucleotide probes

Autor: JG McFarland, RH Aster, JB Bussel, JG Gianopoulos, RS Derbes, PJ Newman

Publikováno v: Blood. 78:2276-2282

The prediction of neonatal alloimmune thrombocytopenia (NATP) in affected families has, in the past, been based on information about gene frequencies of the antigen systems involved, parental phenotyping, and fetal platelet counts. We explored the fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6685a9c250d0ad6c5271f8f3410d9f0f
https://doi.org/10.1182/blood.v78.9.2276.bloodjournal7892276

Zobrazit plný text záznamu

Analysis of rodent platelet glycoprotein IIb: evidence for evolutionarily conserved domains and alternative proteolytic processing

Autor: M Poncz, PJ Newman

Publikováno v: Blood. 75:1282-1289

Recently, the full-length primary amino acid sequence for human glycoproteins (GP) IIb and IIIa have been derived from their respective cDNAs. Potential functional domains within these proteins have been proposed based primarily on homology with simi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d66db6f2397236f6dd0f6cf5efd9cae
https://doi.org/10.1182/blood.v75.6.1282.bloodjournal7561282

Zobrazit plný text záznamu

Monoclonal antibodies bound to subunits of the integrin GPIIb-IIIa are internalized and interfere with filopodia formation and platelet aggregation

Autor: WM Isenberg, DF Bainton, PJ Newman

Publikováno v: Blood. 76(8)

The monoclonal antibodies Tab and AP3 are directed, respectively, against GPIIb and GPIIIa, the subunits of the platelet fibrinogen receptor. When added together to platelets, these antibodies prevent adenosine diphosphate (ADP)-induced platelet aggr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cb4d7a9de2c59182f87f60f1c46a96
https://pubmed.ncbi.nlm.nih.gov/2207330

Zobrazit plný text záznamu

A single amino acid substitution flanking the fourth calcium binding domain of alpha IIb prevents maturation of the alpha IIb beta 3 integrin complex

Autor: Da, Wilcox, Jl, Wautier, Dominique Pidard, Pj, Newman

Publikováno v: Europe PubMed Central

To define specific structural domains involved in the biosynthesis and processing of integrin subunits, we examined the biosynthesis of normal and mutated forms of the platelet-specific integrin alpha IIb beta 3. Platelet mRNA was isolated from a Gla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b36da6f41889bf682fdc73598ddd5fc9
http://europepmc.org/abstract/med/7508443

Zobrazit plný text záznamu

Amino acid complexes of iron. I. Iron(II) complexes of thioglycollic acid, L-cysteine and related ligands

Autor: KS Murray, PJ Newman

Publikováno v: Australian Journal of Chemistry. 28:773

A number of solid complexes, most of which are extremely unstable in air, have been isolated from reactions between aqueous iron(II) and the sulphur-containing ligands thioglycollic acid, L-cysteine, L-cysteine methyl ester and DL-methionine. The 1 :

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea80da56df190a6edf5b300226543d6c
https://doi.org/10.1071/ch9750773

Zobrazit plný text záznamu

Akademický článek

Antigen-specific immunotherapy for platelet alloimmune disorders.

Autor: Newman DK; Versiti Blood Research Institute, Milwaukee, WI, United States; Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: dknewman@versiti.org., Newman PJ; Versiti Blood Research Institute, Milwaukee, WI, United States; Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: pjnewman@versiti.org.

Publikováno v: Human immunology [Hum Immunol] 2024 Nov; Vol. 85 (6), pp. 111172. Date of Electronic Publication: 2024 Nov 08.

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání