Pharmacological properties of orally active inhibitors of herpes simplex virus (HSV) thymidine kinase

Autor: K. E. B. Parkes, JH Merrett, SA Malcolm, AM Watkins, NA Roberts, Joseph Armstrong Martin, Robert Wilson Lambert, MJ Mulqueen, P. Wong Kai-In, G. J. Thomas, PJ Dunford

Publikováno v: Antiviral Research. 34:A47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::296740de25e21b9fef5631f43a2cd00b
https://doi.org/10.1016/s0166-3542(97)83159-2

Viral thymidine kinase in essential for the spread of herpes simplex virus (HSV) induced zosteriform lesions in vivo

Autor: G. J. Thomas, P. Wong Kai-In, AM Watkins, Robert Wilson Lambert, MJ Mulqueen, SA Malcolm, Joseph Armstrong Martin, JH Merrett, K. E. B. Parkes, NA Roberts, PJ Dunford

Publikováno v: Antiviral Research. 34:A80

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d46986836bdd668fbb4b9f6e0fbf099
https://doi.org/10.1016/s0166-3542(97)83275-5

Toreforant, an orally active histamine H 4 -receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study.

Autor: Boyle DL; Division of Rheumatology, Allergy and Immunology, UC San Diego School of Medicine, La Jolla, San Diego, CA, USA., DePrimo SE; Immunology Biomarkers, Janssen Research & Development LLC, San Diego, CA, USA., Calderon C; Immunology Clinical Development, Janssen Research & Development LLC, Spring House, PA, USA., Chen D; Biostatistics, Janssen Research & Development LLC, Spring House, PA, USA., Dunford PJ; Immunology Clinical Development, Janssen Research & Development LLC, Spring House, PA, USA., Barchuk W; Immunology Clinical Development, Janssen Research & Development LLC, Spring House, PA, USA.; Immunology Clinical Development, Eli Lilly and Company, San Diego, CA, USA., Firestein GS; Division of Rheumatology, Allergy and Immunology, UC San Diego School of Medicine, La Jolla, San Diego, CA, USA., Thurmond RL; Immunology Clinical Development, Janssen Research & Development LLC, Spring House, PA, USA. RThurmon@its.jnj.com.

Publikováno v: Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2019 Apr; Vol. 68 (4), pp. 261-274. Date of Electronic Publication: 2019 Feb 09.

The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects.

Autor: Kollmeier A; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.)., Francke K; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.)., Chen B; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.)., Dunford PJ; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.)., Greenspan AJ; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.)., Xia Y; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.)., Xu XL; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.)., Zhou B; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.)., Thurmond RL; Janssen Research & Development, LLC, San Diego, California (A.K., B.C., P.J.D., A.J.G., X.L.X., R.L.T.); Parexel International, London, United Kingdom (K.F.); and Janssen Research & Development, LLC, Spring House, Pennsylvania (Y.X., B.Z.) rthurmon@its.jnj.com.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2014 Jul; Vol. 350 (1), pp. 181-7. Date of Electronic Publication: 2014 May 09.

Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.

Autor: Savall BM; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Chavez F, Tays K, Dunford PJ, Cowden JM, Hack MD, Wolin RL, Thurmond RL, Edwards JP

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2014 Mar 27; Vol. 57 (6), pp. 2429-39. Date of Electronic Publication: 2014 Feb 21.