Zobrazeno 1 - 10
of 551
pro vyhledávání: '"PINK1/Parkin"'
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-15 (2024)
Abstract Background Although the exact role of mitophagy in the pathogenesis of diabetic cardiomyopathy (DCM) caused by type 2 diabetes mellitus (T2DM) remains controversial, recent studies revealed inhibition of mitophagy exacerbates cardiac injury
Externí odkaz:
https://doaj.org/article/f97c9ce036c148b499a8aab768e6d1cc
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Pulmonary fibrosis is a chronic interstitial lung disease with no curative therapeutic treatment, leading to significant mortality. The aims of this study were to investigate the regulatory mechanisms of mitophagy in the progression of pulmo
Externí odkaz:
https://doaj.org/article/2ff06c7822414b46a05e56087d03544d
Autor:
Nannan Zhao, Yuxin Wang, Yu He, Jiayi Hang, Shuai Wang, Tianzi Huang, Huigang Sun, Haixu Xu, Jue Cui
Publikováno v:
Italian Journal of Animal Science, Vol 23, Iss 1, Pp 758-768 (2024)
High‐producing dairy cows are susceptible to altered redox balance owing to their high secretion and strong metabolism during transition to lactation. Previously reports demonstrated that pterostilbene (PTE) alleviate hydrogen peroxide (H2O2)-induc
Externí odkaz:
https://doaj.org/article/f3d675042ae649f9a461f5ea2bb1c591
Publikováno v:
Journal of Asthma and Allergy, Vol Volume 17, Pp 717-731 (2024)
Hong Ding,1 Xiaofan Lu,2 Huimin Wang,3 Wenming Chen,3 Bing Niu4 1Otolaryngology Department, The Second Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan Province, People’s Republic of China; 2Respiratory Department, T
Externí odkaz:
https://doaj.org/article/46e75f7ea15740a89d83e4949583946e
Publikováno v:
Reproductive Biology and Endocrinology, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Reproductive aging not only affects the fertility and physical and mental health of women but also accelerates the aging process of other organs. There is an urgent need newfor novel mechanisms, targets, and drugs to break the vicious cycle
Externí odkaz:
https://doaj.org/article/2471f0a208d64c7fb8fa5052b0da8662
Publikováno v:
Brain Circulation, Vol 10, Iss 2, Pp 154-161 (2024)
BACKGROUND: Electroacupuncture (EA) is a promising alternative therapy for migraine, with mitochondrial dysfunction hypothesized as a pivotal mechanism in migraine pathophysiology. This research endeavors to investigate the therapeutic potential of E
Externí odkaz:
https://doaj.org/article/1ae1f3894d2c457abd647b5f367a3bf5
Autor:
Yangbo Li, Pengzhan He, Ying Chen, Jiaming Hu, Beiying Deng, Chuan Liu, Baoping Yu, Weiguo Dong
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Colorectal cancer (CRC) is a prevalent global health issue, with 5-fluorouracil (5-FU) being a commonly used chemotherapeutic agent for its treatment. However, the efficacy of 5-FU is often hindered by drug tolerance. Sodium butyrate (NaB),
Externí odkaz:
https://doaj.org/article/38d3ae8bb8a9437f998fb423f59e3fcc
Benzophenone-3 exposure induced apoptosis via impairing mitochondrial function in human chondrocytes
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 287, Iss , Pp 117286- (2024)
Osteoarthritis (OA) is a chronic joint disease affecting millions of adults worldwide, characterized by degeneration of articular cartilage. Many environmental risk factors contribute to OA development. Benzophenone-3 (BP-3), a commonly used ultravio
Externí odkaz:
https://doaj.org/article/e4af2839c08647eb85a889f4d09ee7a8
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107466- (2024)
Myocardial ischemia causes extensive damage, further exacerbated by reperfusion, a phenomenon called myocardial ischemia/reperfusion injury (MIRI). Nowadays, the pathological mechanisms of MIRI have received extensive attention. Oxidative stress, mul
Externí odkaz:
https://doaj.org/article/2b1928c955d24afc8393c1a752d23333
Publikováno v:
Brain Research Bulletin, Vol 216, Iss , Pp 111043- (2024)
Objective: This study aimed to further elucidate the mechanism of ginsenoside Rg1 in the treatment of cerebral ischemia-reperfusion. Methods: In this study, we observed the apoptosis of RM cells (microglia) after oxygen-glucose deprivation/reoxygenat
Externí odkaz:
https://doaj.org/article/735cc12c362d4f7ead0b4c85189d83d3