Zobrazeno 1 - 10
of 142
pro vyhledávání: '"PIK3CG"'
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23165- (2024)
Multiple myeloma (MM) is a malignant plasma cell disease. The activity of PIK3CG (PI3K catalytic subunit γ) is regulated directly by G-protein-coupled receptor and has been confirmed to be highly expressed in MM cells. This study aimed to determine
Externí odkaz:
https://doaj.org/article/1445513486fd4851b2c5aa72cc33a940
Autor:
Noah J Harris, Meredith L Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E Moeller, Eleanor Sheeky, Scott D Hansen, Calvin K Yip, John E Burke
Publikováno v:
eLife, Vol 12 (2023)
PI3Kγ is a critical immune signaling enzyme activated downstream of diverse cell surface molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ subunits released from activated GPCRs. PI3Kγ can form two distinct complexes, with th
Externí odkaz:
https://doaj.org/article/e0ae711fee134081811275437049e492
Akademický článek
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Autor:
Laura Castañeda-Partida, Rodolfo Ocadiz-Delgado, José Manuel Sánchez-López, Enrique García-Villa, José Gabriel Peñaloza-González, Martha Margarita Velázquez-Aviña, José Refugio Torres-Nava, Jorge Alfonso Martín-Trejo, Karina Solís-Labastida, Francisco Xavier Guerra-Castillo, Vilma Carolina Bekker-Méndez, Víctor Hugo Rosales-García, Dámaris Romero-Rodríguez, Raúl Mojica-Espinoza, Alfonso Mendez-Tenorio, Crystel A. Ramírez-Calzada, Elízabeth Álvarez-Ríos, Juan Manuel Mejía-Aranguré, Patricio Gariglio
Publikováno v:
Discover Oncology, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract Mexico City has one of the highest incidences of acute lymphoblastic leukemia (ALL) globally, with patients showing low survival, and high relapse rates. To gain more insight into the molecular features of B-ALL in Mexican children, we isola
Externí odkaz:
https://doaj.org/article/5f0b3da6559342ac99a6797bbd8f8c0c
Autor:
Qiong Liu, Yushu Dong, Germaine Escames, Xue Wu, Jun Ren, Wenwen Yang, Shaofei Zhang, Yanli Zhu, Ye Tian, Darío Acuña‐Castroviejo, Yang Yang
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)
Abstract Sepsis causes multiple organ injuries, among which the heart is one most severely damaged organ. Melatonin (MEL) alleviates septic myocardial injury, although a systematic and comprehensive approach is still lacking to understand the precise
Externí odkaz:
https://doaj.org/article/80ac217d2294422c9250308cee050efe
Akademický článek
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Akademický článek
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Autor:
Erin M. Taylor, Stephanie D. Byrum, Jacob L. Edmondson, Christopher P. Wardell, Brittany G. Griffin, Sara C. Shalin, Murat Gokden, Issam Makhoul, Alan J. Tackett, Analiz Rodriguez
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-9 (2020)
Abstract Melanoma brain metastases (MBM) portend a grim prognosis and can occur in up to 40% of melanoma patients. Genomic characterization of brain metastases has been previously carried out to identify potential mutational drivers. However, to date
Externí odkaz:
https://doaj.org/article/2a33993e84a6480b9d4e9f4e173ccc47
Publikováno v:
Cancer Management and Research, Vol Volume 12, Pp 2641-2651 (2020)
Jun Chang,1,2 Ling Hong,2 Yaozhong Liu,3 Yiwen Pan,2 Hao Yang,2 Wenrui Ye,3 Keli Xu,4 Zhijian Li,1 Shubing Zhang1,2,5,6 1Department of Anesthesiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, People’s Republi
Externí odkaz:
https://doaj.org/article/547e16454c2b40dca265515d48ce251c
Autor:
Manoj K Rathinaswamy, Zied Gaieb, Kaelin D Fleming, Chiara Borsari, Noah J Harris, Brandon E Moeller, Matthias P Wymann, Rommie E Amaro, John E Burke
Publikováno v:
eLife, Vol 10 (2021)
Class I Phosphoinositide 3-kinases (PI3Ks) are master regulators of cellular functions, with the class IB PI3K catalytic subunit (p110γ) playing key roles in immune signalling. p110γ is a key factor in inflammatory diseases and has been identified
Externí odkaz:
https://doaj.org/article/7f784cecc93e43a98a6ad064bf0019ce