Zobrazeno 1 - 10
of 14
pro vyhledávání: '"PIK3CA Gene Amplification"'
Autor:
Wolfgang Schroeder, Max Kraemer, Alexander Quaas, Ahlem Essakly, Christiane Bruns, Thomas Zander, Axel M. Hillmer, Heike Loeser, Seung-Hun Chon, Florian Gebauer, Reinhard Buettner, Hakan Alakus
Publikováno v:
Translational Oncology
Translational Oncology, Vol 13, Iss 2, Pp 157-164 (2020)
Translational Oncology, Vol 13, Iss 2, Pp 157-164 (2020)
Gene amplifications of PIK3CA or KRAS induce a downstream activation of the AKT-mTOR or RAF-ERK-pathways. Interactions of the active AKT pathway have been implicated in the inflammatory tumor microenvironment. Nothing is known about these interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea8641796ca3e10956adf0dc78c377a
https://pubmed.ncbi.nlm.nih.gov/31865178
https://pubmed.ncbi.nlm.nih.gov/31865178
Autor:
Sultana Razia, Masako Ishikawa, Noriyoshi Ishikawa, Satoru Nakayama, Toshiko Minamoto, Satoru Kyo, Kentaro Nakayama, Tomoka Ishibashi, Kohei Nakamura, Yoshiro Otsuki, Kouji Iida
Publikováno v:
Experimental and therapeutic medicine. 18(3)
The aim of the present study was to evaluate the mutation and amplification status of the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) gene, as well as the association with clinicopathological characteristics and progn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a015422b23022716232007c583d82d4
https://pubmed.ncbi.nlm.nih.gov/31410178
https://pubmed.ncbi.nlm.nih.gov/31410178
Autor:
Saad A. Khan, Julie E. Bauman
Publikováno v:
Clinical Investigation. 4:1123-1138
Phosphatidyl-inositol 3-kinase/Akt/mammalian target of rapamycin pathway (PI3K/Akt/mTOR) is a critical signal transduction pathway in mammalian cellular biology, and is important to energy homeostasis, growth and survival. Activation of the pathway i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89108c78e2aa4dc5604c5a1196cf77c8
https://doi.org/10.4155/cli.14.88
https://doi.org/10.4155/cli.14.88
Autor:
Nazik Elmalaika Husain, Rawia Eljaili Elmassry, Nassr Eldin M.A. Shrif, Arwa Elaagip, Aisha Osman Mohammed
Publikováno v:
F1000Research. 8:1564
Background: Phosphatidylinositol3-kinase, catalytic, α-polypeptide (PIK3CA) gene is frequently amplified in ovarian carcinoma (OC). To the best of our knowledge, there is a dearth of published reports about the amplification of the PIK3CA gene among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a4890db9f056607cc3920571f387a14
https://doi.org/10.12688/f1000research.19718.1
https://doi.org/10.12688/f1000research.19718.1
Autor:
Jamel Daoud, Wafa Mnejja, Ali Gargouri, Mounir Frikha, Ali Fendri, Raja Mokdad-Gargouri, Abdelmonem Ghorbel, Tahia Sellami-Boudawara, Abdelmajid Khabir
Publikováno v:
Cancer Science. 100:2034-2039
PI3Ks (phosphatidylinositol 3-kinases) are lipid kinases that regulate signalling pathways involved in cell proliferation, motility, and adhesion. Somatic mutations and amplification of the PIK3CA gene have been reported in various types of human can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eaed92373415692f5fc3f3384bf8956
https://doi.org/10.1111/j.1349-7006.2009.01292.x
https://doi.org/10.1111/j.1349-7006.2009.01292.x
Autor:
Khawla S. Al-Kuraya, Azhar R. Hussain, Jehad Abubaker, Samar Alhomoud, Zeenath Jehan, Shahab Uddin, Alaa Abduljabbar, Nasser Al-Sanea, Mehar Sultana, Fouad Al-Dayel, Ghazi Alsbeih, Rong Bu, Prashant Bavi, Luai H. Ashari
Publikováno v:
The Journal of Pathology. 219:337-346
Using a DNA microarray approach to screen for gene copy number changes in 20 colorectal (CR) carcinoma samples and filtering for high-level DNA copy number changes, we detected an amplicon at 3q26 containing the PIK3CA gene. Fluorescence in situ hybr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d02f7edefa1135b4348aa21e974b26b
https://doi.org/10.1002/path.2601
https://doi.org/10.1002/path.2601
Autor:
Young Mog Shim, Susan S. Jewell, Jun Chul Park, Sung Kwan Shin, Dae Joon Kim, Hyunki Kim, Sang Kil Lee, Yoon Sung Bae, Seung Eun Lee, Hyo Song Kim, Byoung Chul Cho, Chang Geol Lee, Hye Ryun Kim, Yong Chan Lee, Yoon-La Choi, Hyunsoo Chung, Jin Hur
Publikováno v:
Oncotarget
To investigate the clinicopathologic characteristics and the prognostic impact of PIK3CA gene amplification in curatively resected esophageal squamous cell carcinoma (ESCC). Using 534 curatively resected ESCCs, the PIK3CA gene copy number was evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fe4e0ee170054cd6362b0869509572
https://pubmed.ncbi.nlm.nih.gov/27095573
https://pubmed.ncbi.nlm.nih.gov/27095573
Publikováno v:
Pathology oncology research : POR. 22(2)
Molecular alterations in PIK3CA oncogene that encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K p110α) are commonly found in human cancers. In this study, we examined the expression of PI3K p110α and PIK3CA gene amplificat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b4707b7da86697cd628339a625b327
https://pubmed.ncbi.nlm.nih.gov/26581613
https://pubmed.ncbi.nlm.nih.gov/26581613
Autor:
Richard B. Pearson, Briony E. Cristiano, Christine S. F. Hooi, Karen G. Montgomery, Sarah E. Russell, Marianne L. Ciavarella, Ian G. Campbell, Wayne A. Phillips, David Y.H. Choong
Publikováno v:
Cancer Research. 64:7678-7681
Phosphatidylinositol 3′-kinases are lipid kinases with important roles in neoplasia. Recently, a very high frequency of somatic mutations in PIK3CA has been reported among a large series of colorectal cancers. However, the relevance of PIK3CA mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6262ac08400cafb97d72280d42081d
https://doi.org/10.1158/0008-5472.can-04-2933
https://doi.org/10.1158/0008-5472.can-04-2933
Autor:
Mohammad Firoozinia, Soheil Zorofchian Moghadamtousi, Sonia Nikzad, Mohammad Zareian Jahromi, Habsah Abdul Kadir
Publikováno v:
International Journal of Medical Sciences
A family of PI3Ks is the lipid kinases, which enhance intracellular pools of phosphatidyl inositol 3,4,5-tri-phosphate (PIP3) through phosphorylating its precursor. Amplifications and deletions of genes, as well as somatic missense of the PIK3CA gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951d4d522111e36237674c1e92a1f8bf
https://pubmed.ncbi.nlm.nih.gov/24782652
https://pubmed.ncbi.nlm.nih.gov/24782652