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Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease

Autor: Wei Lian, Hui Liu, Li Yan Sun, Yun Qi Liu, Si Lu Cui, Yue Wang, Quan Quan Song, Qing Deng, Shao Ping Wang, Yan Hong Cao, Xue Ying Zhang, Yuan Yuan Jiang, Hong Yan Lv, Li Bin Duan, Jun Yu

Publikováno v: Journal of Orthopaedic Surgery and Research, Vol 13, Iss 1, Pp 1-7 (2018)

Abstract Background Kashin-Beck disease (KBD) is an endemic, chronic, degenerative osteoarthropathy. KBD is usually diagnosed by using X-ray image and clinical symptoms, lacking of serological biomarkers. The serum level of PIICP, PIIANP, and PIIBNP

Externí odkaz: https://doaj.org/article/4e40e382f51c4ca394124a354dc1b6b7

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Akademický článek

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Biomarkers of Hand Osteoarthritis Are Detectable after Mechanical Exercise

Autor: Anna Bender, Ulrich Kaesser, Gerrit Eichner, Georg Bachmann, Juergen Steinmeyer

Publikováno v: Journal of Clinical Medicine
Volume 8
Issue 10
Journal of Clinical Medicine, Vol 8, Iss 10, p 1545 (2019)

Background: Hand osteoarthritis (OA) is one of the most common joint diseases, but studies on biomarkers are rare. The aim of this explorative study was (a) to evaluate potential biomarkers of hand OA, (b) to identify an optimal time point to sample

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::043053e7b3bdb74bde62a906e5dc540b

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A Novel High Sensitivity Type II Collagen Blood-Based Biomarker, PRO-C2, for Assessment of Cartilage Formation

Autor: Ole Simonsen, Anne-Christine Bay-Jensen, Christoph Ladel, Yunyun Luo, Morten A. Karsdal, Ali Mobasheri, Kim Henriksen, Yi He, Natasja Stæhr Gudmann, D. Reker, M. Michaelis

Publikováno v: International Journal of Molecular Sciences
Volume 19
Issue 11
Luo, Y, He, Y, Reker, D, Gudmann, N S, Henriksen, K, Simonsen, O, Ladel, C, Michaelis, M, Mobasheri, A, Karsdal, M & Bay-Jensen, A C 2018, ' A Novel High Sensitivity Type II Collagen Blood-Based Biomarker, PRO-C2, for Assessment of Cartilage Formation ', International Journal of Molecular Sciences, vol. 19, no. 11, 3485 . https://doi.org/10.3390/ijms19113485
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3485 (2018)
Luo, Y, He, Y, Reker, D, Gudmann, N S, Henriksen, K, Simonsen, O, Ladel, C, Michaelis, M, Mobasheri, A, Karsdal, M & Bay-Jensen, A C 2018, ' A Novel High Sensitivity Type II Collagen Blood-Based Biomarker, PRO-C2, for Assessment of Cartilage Formation ', International Journal of Molecular Sciences (Online), vol. 19, no. 11, 3485 . https://doi.org/10.3390/ijms19113485

N-terminal propeptide of type II collagen (PIINP) is a biomarker reflecting cartilage formation. PIINP exists in two main splice variants termed as type IIA and type IIB collagen NH2-propeptide (PIIANP, PIIBNP). PIIANP has been widely recognized as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c645d0d61afe785280d49d9c6250c66

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Serum levels of PIICP, PIIANP, and PIIBNP are decreased in patients with an endemic osteochondropathy, Kashin-Beck disease

Autor: Si Lu Cui, Li Yan Sun, Li Bin Duan, Hong Lv, Shao Ping Wang, Yuan Yuan Jiang, Wei Lian, Yun Qi Liu, Yue Wang, Jun Yu, Quan Quan Song, Hui Liu, Xue Ying Zhang, Qing Deng, Yan Hong Cao

Publikováno v: Journal of Orthopaedic Surgery and Research
Journal of Orthopaedic Surgery and Research, Vol 13, Iss 1, Pp 1-7 (2018)

Background Kashin-Beck disease (KBD) is an endemic, chronic, degenerative osteoarthropathy. KBD is usually diagnosed by using X-ray image and clinical symptoms, lacking of serological biomarkers. The serum level of PIICP, PIIANP, and PIIBNP can speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2497840b929e9f0c48f244b8d078cb94
http://europepmc.org/articles/PMC5975620

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Heritability assessment of cartilage metabolism. A twin study on circulating procollagen IIA N-terminal propeptide (PIIANP)

Autor: Peter Junker, Heidi Lausten Munk, Kirsten Ohm Kyvik, Grith Lykke Sørensen, Jacob v. B. Hjelmborg, Anders Jørgen Svendsen

Publikováno v: Munk, H L, Svendsen, A J, Hjelmborg, J V B, Sorensen, G L, Kyvik, K O & Junker, P 2014, ' Heritability assessment of cartilage metabolism. A twin study on circulating procollagen IIA N-terminal propeptide (PIIANP) ', Osteoarthritis and Cartilage, vol. 22, no. 8, pp. 1142-1147 . https://doi.org/10.1016/j.joca.2014.06.027

OBJECTIVE: The aim of this investigation was to estimate the heritability of circulating collagen IIA N-terminal propeptide (PIIANP) by studying mono- and dizygotic healthy twin pairs at different age and both genders.DESIGN: 598 monozygotic (MZ) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1b0b241bc46f57cabaec8547c9640f

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Biochemical markers of type II collagen breakdown and synthesis are positioned at specific sites in human osteoarthritic knee cartilage

Autor: P.W. Kristensen, Patrick Garnero, Per Kjærsgaard-Andersen, Thomas Levin Andersen, N. Charni-Ben Tabassi, Anne-Christine Bay-Jensen, Jean-Marie Delaissé, Linda J. Sandell

Publikováno v: Jensen, A-C B, Levin Andersen, T, Charni-Ben Tabassi, N, Wagner Kristensen, P, Kjærsgaard-Andersen, P, Sandell, L, Garnero, P & Delaissé, J-M 2007, ' Biochemical markers of type II collagen breakdown and synthesis are positioned at specific sites in human osteoarthritic knee cartilage ', Osteoarthritis and Cartilage . https://doi.org/10.1016/j.joca.2007.09.006

Udgivelsesdato: Oct-18 OBJECTIVE: To investigate whether type II collagen turnover markers used for osteoarthritis (OA) activity evaluation in body fluids can be detected at the level of specific histological features of OA cartilage tissue, as well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e28ccc4e535f0d5b7b950e3958b3b4
https://doi.org/10.1016/j.joca.2007.09.006

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