Multi-omic analysis of biological aging biomarkers in long-term calorie restriction and endurance exercise practitioners: A cross-sectional study.

Autor: Fiorito G; Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Tosti V; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Polidoro S; Department of Translational Medicine (DiMET) CAAD Center for Translational Research on Autoimmune and Allergic Disease, University of Eastern Piedmont 'Amedeo Avogadro', Novara, Italy., Bertozzi B; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Veronese N; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy., Cava E; Unit of Dietetic and Clinical Nutrition, San Camillo, Forlanini Hospital, Rome, Italy., Spelta F; Geriatric Unit, AULSS 9 Scaligera, 'Mater Salutis' Hospital, Legnago, Verona, Italy., Piccio L; Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Early DS; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Raftery D; Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Washington, USA., Vineis P; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK., Fontana L; Charles Perkins Center, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.

Publikováno v: Aging cell [Aging Cell] 2024 Dec 18, pp. e14442. Date of Electronic Publication: 2024 Dec 18.

GPR109A expressed on medullary thymic epithelial cells affects thymic Treg development.

Autor: Ni D; Charles Perkins Centre, The University of Sydney, The University of Sydney, New South Wales, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Tan J; Charles Perkins Centre, The University of Sydney, The University of Sydney, New South Wales, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Robert R; Department of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Taitz J; Charles Perkins Centre, The University of Sydney, The University of Sydney, New South Wales, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Ge A; Charles Perkins Centre, The University of Sydney, The University of Sydney, New South Wales, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Potier-Villette C; Charles Perkins Centre, The University of Sydney, The University of Sydney, New South Wales, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Reyes JGA; Charles Perkins Centre, The University of Sydney, The University of Sydney, New South Wales, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Spiteri A; Charles Perkins Centre, The University of Sydney, The University of Sydney, New South Wales, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Viral Immunopathology Laboratory, Infection, Immunity and Inflammation Research Theme, The School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Wishart C; Charles Perkins Centre, The University of Sydney, The University of Sydney, New South Wales, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Viral Immunopathology Laboratory, Infection, Immunity and Inflammation Research Theme, The School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Mackay C; Department of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Piccio L; Charles Perkins Centre, The University of Sydney, The University of Sydney, New South Wales, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., King NJC; Charles Perkins Centre, The University of Sydney, The University of Sydney, New South Wales, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Viral Immunopathology Laboratory, Infection, Immunity and Inflammation Research Theme, The School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Macia L; Charles Perkins Centre, The University of Sydney, The University of Sydney, New South Wales, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.; Sydney Cytometry, The University of Sydney and Centenary Institute, Sydney, New South Wales, Australia.

Publikováno v: European journal of immunology [Eur J Immunol] 2023 Nov; Vol. 53 (11), pp. e2350521. Date of Electronic Publication: 2023 Sep 07.

Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis.

Autor: Ghezzi L; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milano, Italy.; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Lombardia, Italy., Tosti V; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA., Shi L; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Cantoni C; Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, Arizona, USA., Mikesell R; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA., Lancia S; Department of Neurology, Section on Statistical Planning and Analysis, UT Southwestern Medical Center, Dallas, Texas, USA., Zhou Y; UConn Health, Farmington, Connecticut, USA., Obert K; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA., Dula C; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA., Sen MK; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Ge A; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Tolentino M; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA., Bollman B; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA., Don AS; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Matarese G; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Napoli, Campania, Italy.; Consiglio Nazionale delle Ricerche (IEOS-CNR), Istituto per l'endocrinologia e l'oncologia Gaetano Salvatore, Naples, Campania, Italy., Colamatteo A; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Napoli, Campania, Italy., La Rocca C; Consiglio Nazionale delle Ricerche (IEOS-CNR), Istituto per l'endocrinologia e l'oncologia Gaetano Salvatore, Naples, Campania, Italy., Lepore MT; Consiglio Nazionale delle Ricerche (IEOS-CNR), Istituto per l'endocrinologia e l'oncologia Gaetano Salvatore, Naples, Campania, Italy., Raji CA; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA.; Washington University School of Medicine, Mallinckrodt Institute of Radiology, Saint Louis, Missouri, USA., Rahmani F; Washington University School of Medicine, Mallinckrodt Institute of Radiology, Saint Louis, Missouri, USA., Wu GF; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA., Naismith RT; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA., Fontana L; The University of Sydney, Charles Perkins Centre, Sydney, New South Wales, Australia., Cross AH; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA., Salter A; Department of Neurology, Section on Statistical Planning and Analysis, UT Southwestern Medical Center, Dallas, Texas, USA., Piccio L; Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA laura.piccio@sydney.edu.au.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.

Publikováno v: Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2024 Aug 20. Date of Electronic Publication: 2024 Aug 20.

Twelve Weeks of Intermittent Caloric Restriction Diet Mitigates Neuroinflammation in Midlife Individuals with Multiple Sclerosis: A Pilot Study with Implications for Prevention of Alzheimer’s Disease

Autor: Rahmani, F., Ghezzi, L., Tosti, V., Liu, J., Song, S., Anthony T, W., Rajamanickam, J., Obert, K.A., Benzinger, T.L.S., Mittendorfer, B., Piccio, L., Raji, C.A.

Publikováno v: Journal of Alzheimer's Disease. 93:263-273

Background: Multiple sclerosis (MS) is a prototype neuroinflammatory disorder with increasingly recognized role for neurodegeneration. Most first-line treatments cannot prevent the progression of neurodegeneration and the resultant disability. Interv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2969a931397249f5a6e9737001a8c90f
https://doi.org/10.3233/jad-221007

Meta-analysis identifies common gut microbiota associated with multiple sclerosis.

Autor: Lin Q; Department of Computer Science and Engineering, University of Connecticut, Storrs, CT, USA.; Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA., Dorsett Y; Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA., Mirza A; Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Tremlett H; Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Piccio L; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Brain and Mind Centre, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia., Longbrake EE; Departments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, 06511, USA., Choileain SN; Departments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, 06511, USA., Hafler DA; Departments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, 06511, USA., Cox LM; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham & Women's Hospital, Boston, MA, 02115, USA., Weiner HL; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham & Women's Hospital, Boston, MA, 02115, USA., Yamamura T; Department of Immunology, National Institute of Neuroscience, Tokyo, Japan., Chen K; Department of Statistics, University of Connecticut, Storrs, CT, USA., Wu Y; Department of Computer Science and Engineering, University of Connecticut, Storrs, CT, USA., Zhou Y; Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA. yazhou@uchc.edu.

Publikováno v: Genome medicine [Genome Med] 2024 Jul 31; Vol. 16 (1), pp. 94. Date of Electronic Publication: 2024 Jul 31.