Zobrazeno 1 - 10
of 73
pro vyhledávání: '"PI3K signalling"'
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23522- (2024)
Background: Abnormal anillin (ANLN) expression has been observed in multiple tumours and is closely associated with patient prognosis and clinical features. In this study, we systematically elucidated the clinical significance and biological roles of
Externí odkaz:
https://doaj.org/article/ced4719ef708463895b5431fb5ba778f
Akademický článek
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Autor:
Toomey, Cathy E. Richards, Yasir Y. Elamin, Aoife Carr, Kathy Gately, Shereen Rafee, Mattia Cremona, Emer Hanrahan, Robert Smyth, Daniel Ryan, Ross K. Morgan, Susan Kennedy, Lance Hudson, Joanna Fay, Kenneth O’Byrne, Bryan T. Hennessy, Sinead
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10545
PTPN11 encodes the SHP2 protein tyrosine phosphatase that activates the mitogen-activated protein kinase (MAPK) pathway upstream of KRAS and MEK. PTPN11/Shp2 somatic mutations occur frequently in Juvenile myelomonocytic leukaemia (JMML); however, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::ee8c38ffc4f110df942cb7f7cbd611f9
Autor:
Sulaiman, Mahnoor
Cataloged from PDF version of article. Thesis (Master's): Bilkent University, Department of Molecular Biology and Genetics, İhsan Doğramacı Bilkent University, 2023. Includes bibliographical references (leaves 113-121). The PI3K signaling pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3533::e046be2edeca813f8f65e243c5bb7321
https://hdl.handle.net/11693/112021
https://hdl.handle.net/11693/112021
Akademický článek
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Autor:
Sleiman, Katia
The complex signaling pathways downstream of KRAS constitute collateral compensatory mechanisms that contribute to PDAC maintenance and therapy resistance. We used a mouse model with a dual recombinase system, which allows a secondary genetic deletio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______518::35641b15cc86f8d5c0a95de331297955
https://mediatum.ub.tum.de/1687438
https://mediatum.ub.tum.de/1687438
Autor:
Elodie, Montaudon, Rania, El Botty, Sophie, Vacher, Olivier, Déas, Adnan, Naguez, Sophie, Chateau-Joubert, Damien, Treguer, Ludmilla, de Plater, Leïla, Zemoura, Fariba, Némati, André, Nicolas, Alain, Chapelier, Alain, Livartowski, Stefano, Cairo, Catherine, Daniel, Marie, Brevet, Elisabetta, Marangoni, Didier, Meseure, Sergio, Roman-Roman, Ivan, Bieche, Nicolas, Girard, Didier, Decaudin
Publikováno v:
Oncotarget
Significant rational is available for specific targeting of PI3K/AKT/mTOR pathway in the treatment of non-small cell lung cancer (NSCLC). However, almost all clinical trials that have evaluated Pi3K pathway-based monotherapies/combinations did not ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d923927e729d329cdbab52c1300a9cb5
https://pubmed.ncbi.nlm.nih.gov/33889306
https://pubmed.ncbi.nlm.nih.gov/33889306
Autor:
Vuković, Andro
Karcinom štitnjače najčešći je maligni endokrini tumor. Mnogo gena je uključeno u njegov nastanak, a jedan od njih je protoonkogen RET koji kodira za transmembranski receptor RET. Točkaste mutacije protoonkogena RET te njegove fuzije s različ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3630::043f53e5cdf428515306b15688ea02e4
https://repozitorij.pbf.unizg.hr/islandora/object/pbf:3659
https://repozitorij.pbf.unizg.hr/islandora/object/pbf:3659
Autor:
Madhab Kumar Sen, Sunil Kanti Mondal
Publikováno v:
Heliyon
Heliyon, Vol 6, Iss 1, Pp e03106-(2020)
Heliyon, Vol 6, Iss 1, Pp e03106-(2020)
The tumour suppressor gene, PTEN (Phosphatase and Tensin homolog deleted on chromosome Ten), can act as both protein phosphatase and lipid phosphatase, is known to play a vital role in Pi3k signalling pathway. In humans, it is located at 10q23. Loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08a8bd703e29f8fd7bd4962483fc6f6
http://europepmc.org/articles/PMC7002800
http://europepmc.org/articles/PMC7002800
Autor:
Madsen, Ralitsa R.
Publikováno v:
Biochemical Society Transactions
The PI3K/AKT pathway is a key target in oncology where most efforts are focussed on phenotypes such as cell proliferation and survival. Comparatively little attention has been paid to PI3K in stemness regulation, despite the emerging link between acq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c0f639fa42ac62b9f3d03e0c169c14
https://doi.org/10.20944/preprints201911.0170.v1
https://doi.org/10.20944/preprints201911.0170.v1