Zobrazeno 1 - 10
of 96
pro vyhledávání: '"PI3K - AKT pathway"'
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 2869-2881 (2024)
Benchi Cai,* Qitong Wang,* Lifan Zhong, Fang Liu, Xinyu Wang, Tao Chen Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570311, People’s Republic of China*These authors contributed equally to this workCorresponde
Externí odkaz:
https://doaj.org/article/2d7295b9c550448b8103541eb9f1fb42
Akademický článek
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Autor:
Kasun Wanigasooriya, Joao D. Barros-Silva, Louise Tee, Mohammed E. El-asrag, Agata Stodolna, Oliver J. Pickles, Joanne Stockton, Claire Bryer, Rachel Hoare, Celina M. Whalley, Robert Tyler, Toritseju Sillo, Christopher Yau, Tariq Ismail, Andrew D. Beggs
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectivesPartial or total resistance to preoperative chemoradiotherapy occurs in more than half of locally advanced rectal cancer patients. Several novel or repurposed drugs have been trialled to improve cancer cell sensitivity to radiotherapy, with
Externí odkaz:
https://doaj.org/article/a68422d51da247698891b279834c4704
Autor:
Jueying Liu, Yuan Wang, Qianling Pan, Xueqing Chen, Yifeng Qu, Hao Zhu, Li Zheng, Yinghui Fan
Publikováno v:
Frontiers in Surgery, Vol 9 (2022)
Background and AimsHepatic ischemia–reperfusion injury (IRI) is a common phenomenon that occurs after liver transplantation and liver tumor surgery. It can cause liver dysfunction and recovery failure after liver surgery, even leading to acute live
Externí odkaz:
https://doaj.org/article/46365c107d1f4c2ebbe0b74e8da4ad8d
Autor:
Darren Pan, Joshua Richter
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Multiple myeloma remains an incurable disease despite numerous novel agents being approved in the last decade. Furthermore, disease behavior and susceptibility to current treatments often vary drastically from patient to patient. To date there are no
Externí odkaz:
https://doaj.org/article/f8938abde3c242db8b1235e0d23ff9f8
Autor:
Ágata C. Cevey, Paula D. Mascolo, Federico N. Penas, Azul V. Pieralisi, Aldana S. Sequeyra, Gerardo A. Mirkin, Nora B. Goren
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Benznidazole (Bzl), the drug of choice in many countries for the treatment of Chagas disease, leads to parasite clearance in the early stages of infection and contributes to immunomodulation. In addition to its parasiticidal effect, Bzl inhibits the
Externí odkaz:
https://doaj.org/article/a448a705e0d847578212886c8a173008
Autor:
Rachel L. Y. Wong, Megan R. E. Wong, Chik Hong Kuick, Seyed Ehsan Saffari, Meng Kang Wong, Sheng Hui Tan, Khurshid Merchant, Kenneth T. E. Chang, Matan Thangavelu, Giridharan Periyasamy, Zhi Xiong Chen, Prasad Iyer, Enrica E. K. Tan, Shui Yen Soh, N. Gopalakrishna Iyer, Qiao Fan, Amos H. P. Loh
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Neuroblastoma is the commonest extracranial pediatric malignancy. With few recurrent single nucleotide variations (SNVs), mutation-based precision oncology approaches have limited utility, but its frequent and heterogenous copy number variations (CNV
Externí odkaz:
https://doaj.org/article/c94105f2a340474b8a92a8bcd7d1fcc0
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Angiogenesis is essential for the development of tumors. Studies have shown that carcinoma-associated fibroblasts (CAFs) are involved in regulating tumor angiogenesis, but the mechanism remains unclear. Recently, long noncoding RNAs (lncRNAs) have be
Externí odkaz:
https://doaj.org/article/9b734b6dc4f949a0a11bba974e8f036a
Autor:
Rachel Y. Chow, Ung Seop Jeon, Taylor M. Levee, Gurleen Kaur, Daniel P. Cedeno, Linda T. Doan, Scott X. Atwood
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Basal cell carcinoma (BCC) is a locally invasive epithelial cancer that is primarily driven by the Hedgehog (HH) pathway. Advanced BCCs are a critical subset of BCCs that frequently acquire resistance to Smoothened (SMO) inhibitors and identifying pa
Externí odkaz:
https://doaj.org/article/57512013145247da8da7a1914cb3b3af
Autor:
Runzhi Zhu, Yanjie Tu, Jingxia Chang, Haixia Xu, Jean C. Li, Wang Liu, Ahn-Dao Do, Yuxia Zhang, Jinhu Wang, Benyi Li
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundLiver cancer is a leading cause of cancer death worldwide, and novel prognostic factor is needed for early detection and therapeutic responsiveness monitoring. The orphan nuclear receptor NR0B2 was reported to suppress liver cancer developm
Externí odkaz:
https://doaj.org/article/a7e69a8767fc480c9168f6431255554f