Zobrazeno 1 - 10
of 270
pro vyhledávání: '"PI3K/Akt signalling"'
Publikováno v:
Pharmaceutical Biology, Vol 62, Iss 1, Pp 233-249 (2024)
AbstractContext Podophyllotoxin (PPT) derivatives, used in cancer therapy, require development toward enhanced efficacy and reduced toxicity.Objective This study synthesizes PPT derivatives to assess their anticancer activities.Materials and methods
Externí odkaz:
https://doaj.org/article/91dd0963ce8d44339789af0fcf7f98c9
Autor:
Le Jin, Qianjie Yang, Jiafeng Li, Xiang Li, Yutong Xia, Zhitong Chen, Yingying Wen, Liyin Wang, Xiawei Wang, Jianping Tong, Ye Shen, Kuangqi Chen
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 287, Iss , Pp 117345- (2024)
In recent years, concerns have escalated regarding eye health problems arising from Light-emitting diode (LED), which emits high-energy blue light (BL), potentially causing corneal epithelial dysfunctions (CEpD). Nevertheless, the mechanisms underlyi
Externí odkaz:
https://doaj.org/article/7b42a58971b84338a30e067a0bc06f8c
Autor:
Jinlin Nie, Haoran Zhang, Xiaofeng Li, Jiawei Qin, Jiawei Zhou, Yuhui Lu, Nengjia Yang, Yanan Li, Hailiang Li, Cheng Li
Publikováno v:
Heliyon, Vol 10, Iss 20, Pp e38800- (2024)
Gastric cancer (GC) is a common malignant tumour with high incidence and mortality rates worldwide. Despite current treatment modalities, including surgical resection and chemotherapy, challenges such as postoperative recurrence, metastasis and drug
Externí odkaz:
https://doaj.org/article/81fdbc6091dd4ff3868b667ee28c7c89
Publikováno v:
Food and Agricultural Immunology, Vol 34, Iss 1 (2023)
ABSTRACTObjective The study was to investigate the possible mechanism of Lu'an GuaPian tea in treating heart failure (HF) via network pharmacology and molecular docking.Method The target of Lu'an GuaPian tea were screened. The GeneCards, NCBI, and Di
Externí odkaz:
https://doaj.org/article/8f4a36de94cc477396631341a349a02c
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease characterized by a slow progression and caused by the inhalation of harmful particulate matter. Cigarette smoke and air pollutants are the primary contributing factors. Cur
Externí odkaz:
https://doaj.org/article/2fa09527e91f464ca8ed6f5dd1450079
Autor:
Dileep Reddy Rampa, Huiying Feng, Sivakumar Allur-Subramaniyan, Kwanseob Shim, Anton Pekcec, Dongwon Lee, Henri Doods, Dongmei Wu
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background and aims Kinin B1 receptors (B1Rs) are implicated in the pathogenesis of fibrosis. This study examined the anti-fibrotic effects of B1R blockade with BI 113823 in two established mouse models of hepatic fibrosis induced by intrape
Externí odkaz:
https://doaj.org/article/ed741575167b41e39ebe8f2cd2f06414
Autor:
Zongyi Xia, Bing Chen, Chi Zhou, Yitian Wang, Jinyang Ren, Xujin Yao, Yifan Yang, Qi Wan, Zhexun Lian
Publikováno v:
BMC Cardiovascular Disorders, Vol 22, Iss 1, Pp 1-19 (2022)
Abstract Background The diabetic heart exhibits a high sensitivity to ischaemia/reperfusion (I/R) injury. Diabetes mellitus (DM) can affect the efficacy of cardioprotective interventions and reduce the therapeutic potential of existing treatment opti
Externí odkaz:
https://doaj.org/article/a966e5b783cc4b4b8382eab1c86ac599
Publikováno v:
Pharmaceutical Biology, Vol 60, Iss 1, Pp 75-86 (2022)
Context The mechanism of tetrandrine (TET) in hepatocellular carcinoma (HCC) progression and sorafenib (Sora) chemosensitivity deserves investigation. Objective Using network pharmacology approaches to elucidate the mechanisms of TET in HCC. Material
Externí odkaz:
https://doaj.org/article/aab7cbe49ee24c7bb3feab3eed1ab2b9
Publikováno v:
BMC Nephrology, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background The M-type phospholipase A2 receptor (PLA2R)-associated idiopathic membranous nephropathy (IMN) is a common immune-related disease in adults. Vascular endothelial growth factor A (VEGFA) is the key mediator of angiogenesis, which
Externí odkaz:
https://doaj.org/article/7a735b2a54be4641a41d7a76e73b648d
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