Zobrazeno 1 - 10
of 25 513
pro vyhledávání: '"PI3K"'
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-42 (2024)
Abstract The Phosphatidylinositol-3-kinase (PI3K) family is well-known to comprise three classes of intracellular enzymes. Class I PI3Ks primarily function in signaling by responding to cell surface receptor stimulation, while class II and III are mo
Externí odkaz:
https://doaj.org/article/e770822f68524248951df177dbe509f1
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract SASH1 (SAM and SH3 domain containing 1) has been increasingly reported as a tumor suppressor gene. However, there is limited research on the role of SASH1 in breast cancer. This manuscript aims to investigate the mechanism of SASH1 in the oc
Externí odkaz:
https://doaj.org/article/6ee598089f814ea0b98d5a0076dfe23c
Autor:
Zhiyun Shu, Xiangjun Li, Wenqing Zhang, Zixu Huyan, Dong Cheng, Shishun Xie, Hongyuan Cheng, Jiajia Wang, Bing Du
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract Objective This study aimed to reveal the role and mechanism of MG-132 in delaying hyperlipidemia-induced senescence of vascular smooth muscle cells (VSMCs). Methods Immunohistochemistry and hematoxylin-eosin staining confirmed the therapeuti
Externí odkaz:
https://doaj.org/article/5634cf1727c64debb7f80479110fe7b6
Autor:
Zhikun Li, Kai Chen, Qifeng Yu, Yifan Li, Shichao Tong, Ruijun Xu, Ruixi Hu, Yi Zhang, Wei Xu
Publikováno v:
Engineered Regeneration, Vol 5, Iss 3, Pp 342-349 (2024)
Inflammation can initiate osteolysis, which is the breakdown of bone by fully developed osteoclasts. The compound Oleandrin is recognized for its effects against inflammation and tumors. Our objective was to examine the effects of Oleandrin on osteoc
Externí odkaz:
https://doaj.org/article/00c94d9b145540f997f64e97d292b75e
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Objective of the study Hepatocellular carcinoma (HCC) stands as the third leading cause of cancer-related mortality globally. Metastasis, responsible for treatment failures, underscores the urgency to comprehend molecular drivers of invasion
Externí odkaz:
https://doaj.org/article/7ae4fc76d9874dd79500d4a3529e4ea0
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Eriodictyol, a flavonoid distributed in citrus fruits, has been known to exhibit anti-inflammatory activity. In this study, destabilized medial meniscus (DMM)-induced OA model was used to investigate the protective role of eriodictyol on OA.
Externí odkaz:
https://doaj.org/article/f1947aa0355a421a8180ee908e14d13c
Autor:
Du Fei, Fang Wang, Yaohui Wang, Ji Chen, Shendong Chen, Lianpeng Fan, Luhan Yang, Qingyi Ren, Suwit Duangmano, Fukuan Du, Hao Liu, Jie Zhou, Jing Sheng, Yueshui Zhao, Xu Wu, Mingxing Li, Zhangang Xiao, Zhuo Zhang, Xian Jiang
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Circular RNA (circRNA) is thought to mediate the occurrence and development of human cancer and usually acts as a tiny RNA (miRNA) sponge to regulate downstream gene expression. However, it is not clear whether and how circACVR2A (hsa_circ_0
Externí odkaz:
https://doaj.org/article/ff8bbdbb43384290975a05c692cd8b02
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The team aimed to explore the possible functional significance of M6A regulation in Pan-programmed cell death (PCD) among patients with bladder cancer (BLCA). In BLCA patients, the analysis was conducted on the13 patterns of programmed cell
Externí odkaz:
https://doaj.org/article/f98130127a164e5fba63402235235d0c
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 2869-2881 (2024)
Benchi Cai,* Qitong Wang,* Lifan Zhong, Fang Liu, Xinyu Wang, Tao Chen Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570311, People’s Republic of China*These authors contributed equally to this workCorresponde
Externí odkaz:
https://doaj.org/article/2d7295b9c550448b8103541eb9f1fb42