Zobrazeno 1 - 10
of 1 353
pro vyhledávání: '"PI3-Kinase"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Type 1 and type 2 diabetic patients experience alterations in the Central Nervous System, leading to cognitive deficits. Cognitive deficits have been also observed in animal models of diabetes such as impaired sensory perception, as well as deficits
Externí odkaz:
https://doaj.org/article/851ddefe6f3c4925b3b0e095544e102f
Autor:
Rebekka Geißert, Angela Lammert, Stefanie Wirth, Rabea Hönig, Dirk Lohfink, Monika Unger, Denis Pek, Konstantin Schlüter, Theresa Scheftschik, Daniel J. Smit, Manfred Jücker, Andre Menke, Klaudia Giehl
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract K-Ras is the most frequently mutated Ras variant in pancreatic, colon and non-small cell lung adenocarcinoma. Activating mutations in K-Ras result in increased amounts of active Ras-GTP and subsequently a hyperactivation of effector proteins
Externí odkaz:
https://doaj.org/article/6ad39e31b6e94163a40b075a091f8050
Akademický článek
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Akademický článek
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Autor:
Bart Nieuwenhuis, Richard Eva
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 6, Pp 1172-1182 (2022)
Much research has focused on the PI3-kinase and PTEN signaling pathway with the aim to stimulate repair of the injured central nervous system. Axons in the central nervous system fail to regenerate, meaning that injuries or diseases that cause loss o
Externí odkaz:
https://doaj.org/article/09df2801689441b7b7d61c9a33688594
Akademický článek
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Autor:
King, Jason S., Kay, Robert R.
Publikováno v:
Philosophical Transactions: Biological Sciences, 2019 Feb 01. 374(1765), 1-12.
Externí odkaz:
https://www.jstor.org/stable/26577968
Autor:
Kara M. Ruicci, Jalna Meens, Paul Plantinga, William Stecho, Nicole Pinto, John Yoo, Kevin Fung, Danielle MacNeil, Joe S. Mymryk, John W. Barrett, Christopher J. Howlett, Paul C. Boutros, Laurie Ailles, Anthony C. Nichols
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-18 (2020)
Abstract Background Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outcomes from targeting th
Externí odkaz:
https://doaj.org/article/3551d8a27ebe46f4ba35d980ed3dd3e5
Autor:
Kara M. Ruicci, Paul Plantinga, Nicole Pinto, Mohammed I. Khan, William Stecho, Sandeep S. Dhaliwal, John Yoo, Kevin Fung, Danielle MacNeil, Joe S. Mymryk, John W. Barrett, Christopher J. Howlett, Anthony C. Nichols
Publikováno v:
Molecular Oncology, Vol 13, Iss 10, Pp 2160-2177 (2019)
Phosphoinositide 3‐kinase (PI3K) is aberrantly activated in head and neck squamous cell carcinomas (HNSCC) and plays a pivotal role in tumorigenesis by driving Akt signaling, leading to cell survival and proliferation. Phosphorylation of Akt Thr308
Externí odkaz:
https://doaj.org/article/c402a2a973474188835ddb350af751c1
Autor:
Elena Candelotti, Roberto De Luca, Roberto Megna, Mariangela Maiolo, Paolo De Vito, Fabio Gionfra, Zulema Antonia Percario, Monica Borgatti, Roberto Gambari, Paul J. Davis, Hung-Yun Lin, Fabio Polticelli, Tiziana Persichini, Marco Colasanti, Elisabetta Affabris, Jens Z. Pedersen, Sandra Incerpi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Interaction between thyroid hormones and the immune system is reported in the literature. Thyroid hormones, thyroxine, T4, but also T3, act non-genomically through mechanisms that involve a plasma membrane receptor αvβ3 integrin, a co-receptor for
Externí odkaz:
https://doaj.org/article/63d4e9c8bcee492a904682a88820f723