A new model for sensitive detection of zoonotic prions by PrP transgenic Drosophila

Autor: Raymond Bujdoso, John Spiropoulos, Olivier Andreoletti, Alana M. Thackray

Publikováno v: The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (2), pp.100878. ⟨10.1016/j.jbc.2021.100878⟩

International audience; Prions are transmissible protein pathogens most reliably detected by a bioassay in a suitable host, typically mice. However, the mouse bioassay is slow and cumbersome, and relatively insensitive to low titers of prion infectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07e7894706e3ed17baa099100710dce
https://www.repository.cam.ac.uk/handle/1810/323904

Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease

Autor: Marcus J. Allen, Carina Gandy, Simon Lovestone, Linda Partridge, Fiona Kerr, Hrvoje Augustin, Matthew D.W. Piper

Publikováno v: Neurobiol Aging
Neurobiology of Aging

Dietary restriction (DR) extends lifespan in diverse organisms and, in animal and cellular models, can delay a range of aging-related diseases including Alzheimer's disease (AD). A better understanding of the mechanisms mediating these interactions,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6250c1241edbb8f15cea3c664e5c091c