Zobrazeno 1 - 10
of 2 567
pro vyhledávání: '"PHOSPHORYLATED TAU"'
Autor:
Jonna Nilsson, Yiwen Jiang, Malin Johannesson, Marcus Moberg, Rui Wang, Susanne Fabre, Martin Lövdén, Örjan Ekblom, Maria Ekblom
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Blood-based biomarkers of neurodegeneration demonstrate great promise for the diagnosis and prognosis of Alzheimer’s disease. Ultra-sensitive plasma assays now allow for quantification of the lower concentrations in cognitively unimpaired
Externí odkaz:
https://doaj.org/article/bc3631b23d554f7e8305609d52d223f5
Autor:
Miriam Rabl, Leonardo Zullo, Piotr Lewczuk, Johannes Kornhuber, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Francesco Bavato, Boris B. Quednow, Erich Seifritz, Armin von Gunten, Christopher Clark, Julius Popp
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Neuropsychiatric symptoms (NPS) are common in older people, may occur early in the development of dementia disorders, and have been associated with faster cognitive decline. Here, our objectives were to investigate whether plasma
Externí odkaz:
https://doaj.org/article/0f38378ecba046c399aaa3cc26c9200c
Autor:
Xifeng Wang, Huayu Yang, Dengcheng Zhan, Haiying Sun, Qiang Huang, Yiping Zhang, Yue Lin, Gen Wei, Fuzhou Hua, Li Liu, Shibiao Chen
Publikováno v:
Heliyon, Vol 10, Iss 20, Pp e39013- (2024)
Alzheimer's disease (AD) is a gradual neurodegenerative ailment that lacks any disease-modifying intervention. Our objective was to pinpoint pharmacological targets with a focus on amyloid beta (Aβ) and tau to treat and prevent AD in the European po
Externí odkaz:
https://doaj.org/article/9488e6e5b7a341a0aa37c90642243c67
Autor:
Zsolt Huszár, Marie Anne Engh, Márk Pavlekovics, Tomoya Sato, Yalea Steenkamp, Bernard Hanseeuw, Tamás Terebessy, Zsolt Molnár, Péter Hegyi, Gábor Csukly
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Background Measurement of beta-amyloid (Aβ) and phosphorylated tau (p-tau) levels offers the potential for early detection of neurocognitive impairment. Still, the probability of developing a clinical syndrome in the presence of these prote
Externí odkaz:
https://doaj.org/article/8ca4a5e5f360465b9d26946c659a4ae9
Autor:
Qiong-Yao Li, He-Ying Hu, Gao-Wen Zhang, Hao Hu, Ya-Nan Ou, Liang-Yu Huang, An-Yi Wang, Pei-Yang Gao, Li-Yun Ma, Lan Tan, Jin-Tai Yu
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Cardiometabolic multimorbidity is associated with an increased risk of dementia, but the pathogenic mechanisms linking them remain largely undefined. We aimed to assess the associations of cardiometabolic multimorbidity with cereb
Externí odkaz:
https://doaj.org/article/e5bb7541e4be409198edac4ed563ddcf
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Introduction Pre-analytical factors can cause substantial variability in the measurements of cerebrospinal fluid (CSF) and plasma biomarkers of Alzheimer’s disease (AD). However, their effects on the performance of one of the most promisin
Externí odkaz:
https://doaj.org/article/36b149598f45468784621df045dd181c
Autor:
Sofia Toniolo, Sijia Zhao, Anna Scholcz, Benazir Amein, Akke Ganse‐Dumrath, Amanda J. Heslegrave, Sian Thompson, Sanjay Manohar, Henrik Zetterberg, Masud Husain
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION A major limitation in Alzheimer's disease (AD) research is the lack of the ability to measure cognitive performance at scale—robustly, remotely, and frequently. Currently, there are no established online digital platforms vali
Externí odkaz:
https://doaj.org/article/5f95bed881b641ef88636a298492a358
Akademický článek
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Autor:
Takanobu Ishiguro, Kensaku Kasuga
Publikováno v:
Brain Sciences, Vol 14, Iss 9, p 859 (2024)
Progressive Supranuclear Palsy (PSP) is the most common four-repeat tauopathy. PSP cases are typically characterized by vertical gaze palsy and postural instability; however, various phenotypes have been reported, making antemortem diagnosis based on
Externí odkaz:
https://doaj.org/article/92d8eb0943f542dbb9e8c7a8eb54c5b0
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1781 (2024)
(1) Background: Frontotemporal lobar degeneration (FTLD) is a generic term which refers to multiple pathologies, including FTLD-tau. The most common FTLD-tau diseases are Pick’s disease (PiD), progressive supranuclear palsy (PSP) and corticobasal d
Externí odkaz:
https://doaj.org/article/c462910b8c4b4a67aa7ee3ed27e65c67