Zobrazeno 1 - 10
of 118
pro vyhledávání: '"PHOSPHO1"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 4, Pp 1711-1725 (2024)
Drug repurposing offers an efficient approach to therapeutic development. In this study, our bioinformatic analysis first predicted an association between obesity and lansoprazole (LPZ), a commonly prescribed drug for gastrointestinal ulcers. We went
Externí odkaz:
https://doaj.org/article/c2007cf541b945d1ac600dc4cb899865
Akademický článek
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Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Emerging evidence suggests that phosphoethanolamine/phosphocholine phosphatase 1 (PHOSPHO1), a specific phosphoethanolamine and phosphocholine phosphatase, is involved in energy metabolism. In this review, we describe the structure and regulation of
Externí odkaz:
https://doaj.org/article/2940c2dbaa444b99a9cd45b12a8c7ab5
Autor:
Karla J. Suchacki, Nicholas M. Morton, Calvin Vary, Carmen Huesa, Manisha C. Yadav, Benjamin J. Thomas, Sophie Turban, Lutz Bunger, Derek Ball, Martin E. Barrios-Llerena, Anyonya R. Guntur, Zohreh Khavandgar, William P. Cawthorn, Mathieu Ferron, Gérard Karsenty, Monzur Murshed, Clifford J. Rosen, Vicky E. MacRae, Jose Luis Millán, Colin Farquharson
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background The classical functions of the skeleton encompass locomotion, protection and mineral homeostasis. However, cell-specific gene deletions in the mouse and human genetic studies have identified the skeleton as a key endocrine regulat
Externí odkaz:
https://doaj.org/article/23dc81b350d5458086f9e23af1515cc1
Akademický článek
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Kniha
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Publikováno v:
JBMR Plus, Vol 3, Iss 7, Pp n/a-n/a (2019)
ABSTRACT Since its characterization two decades ago, the phosphatase PHOSPHO1 has been the subject of an increasing focus of research. This work has elucidated PHOSPHO1's central role in the biomineralization of bone and other hard tissues, but has a
Externí odkaz:
https://doaj.org/article/9965aa2f68a44f82882827bc41d61e0f
Autor:
Houston, Dean, Stephen, Louise, Jayash, Soher Nagi, Myers, Katherine, Little, Kirsty, Hopkinson , Mark, Pitsillides, Andrew, MacRae, Vicky, millan, jose luis, Staines, Katherine A., Farquharson, Colin
Publikováno v:
Houston, D, Stephen, L, Jayash, S N, Myers, K, Little, K, Hopkinson, M, Pitsillides, A, MacRae, V, millan, J L, Staines, K A & Farquharson, C 2022, ' Increased PHOSPHO1 and Alkaline Phosphatase expression during the anabolic bone response to intermittent parathyroid hormone delivery : Control of PHOSPHO1 and TNAP expression by iPTH ', Cell Biochemistry and Function, pp. 1-13 . https://doi.org/10.1002/cbf.3772
The administration of intermittent parathyroid hormone (iPTH) is anabolic to the skeleton. Recent studies with cultured osteoblasts have revealed that the expression of PHOSPHO1, a bone-specific phosphatase essential for the initiation of mineralisat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3094::484c193082ada9458bfd48cb43ce48c3
https://www.pure.ed.ac.uk/ws/files/318278096/Cell_Biochemistry_Function_2022_Houston_Increased_PHOSPHO1_and_alkaline_phosphatase_expression_during_the_anabolic.pdf
https://www.pure.ed.ac.uk/ws/files/318278096/Cell_Biochemistry_Function_2022_Houston_Increased_PHOSPHO1_and_alkaline_phosphatase_expression_during_the_anabolic.pdf
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
The transport of mineral ions from the enamel organ-associated blood vessels to the developing enamel crystals involves complex cargo packaging and carriage mechanisms across several cell layers, including the ameloblast layer and the stratum interme
Externí odkaz:
https://doaj.org/article/488ac45891cc4dd08d8b70d1c0351e25
Publikováno v:
Calcified Tissue International
Staines, K A, Myers, K, Little, K, Ralston, S H & Farquharson, C 2021, ' Proton Pump Inhibitors Inhibit PHOSPHO1 Activity and Matrix Mineralisation In Vitro ', Calcified Tissue International . https://doi.org/10.1007/s00223-021-00882-9
Staines, K A, Myers, K, Little, K, Ralston, S H & Farquharson, C 2021, ' Proton Pump Inhibitors Inhibit PHOSPHO1 Activity and Matrix Mineralisation In Vitro ', Calcified Tissue International . https://doi.org/10.1007/s00223-021-00882-9
Proton pump inhibitors (PPIs) have been associated with an increased risk of fragility fractures in pharmaco-epidemiological studies. The mechanism is unclear, but it has been speculated that by neutralising gastric acid, they may reduce intestinal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d401d0f705e837d40eb2ca70f19f47