Zobrazeno 1 - 10
of 488
pro vyhledávání: '"PHILIPPE GROS"'
Autor:
Sebastien Martinez, Shifei Wu, Michael Geuenich, Ahmad Malik, Ramona Weber, Tristan Woo, Amy Zhang, Gun Ho Jang, Dzana Dervovic, Khalid N. Al-Zahrani, Ricky Tsai, Nassima Fodil, Philippe Gros, Steven Gallinger, G. Gregory Neely, Faiyaz Notta, Ataman Sendoel, Kieran Campbell, Ulrich Elling, Daniel Schramek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Functionally characterizing the genetic alterations that drive pancreatic cancer is a prerequisite for precision medicine. Here, we perform somatic CRISPR/Cas9 mutagenesis screens to assess the transforming potential of 125 recurrently mutat
Externí odkaz:
https://doaj.org/article/9926a074e8ba4892ab72de0b846124d2
Autor:
Jean-Frederic Olivier, David Langlais, Thiviya Jeyakumar, Maria J. Polyak, Luc Galarneau, Romain Cayrol, Hua Jiang, Kelly R. Molloy, Guoyue Xu, Harumi Suzuki, John LaCava, Philippe Gros, Nassima Fodil
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract CCDC88B is a risk factor for several chronic inflammatory diseases in humans and its inactivation causes a migratory defect in DCs in mice. CCDC88B belongs to a family of cytoskeleton-associated scaffold proteins that feature protein:protein
Externí odkaz:
https://doaj.org/article/d603e15e96f84a3bbb6cf6e92186e573
Autor:
Yue Liang, Garvit Bhatt, Lin Tze Tung, HanChen Wang, Joo Eun Kim, Marwah Mousa, Viktoria Plackoska, Katalin Illes, Anna A. Georges, Philippe Gros, Linda Henneman, Ivo J. Huijbers, Bhushan Nagar, Anastasia Nijnik
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Myb-like SWIRM and MPN domains 1 (MYSM1) is a chromatin binding protein with deubiquitinase (DUB) catalytic activity. Rare MYSM1 mutations in human patients result in an inherited bone marrow failure syndrome, highlighting the biomedical sig
Externí odkaz:
https://doaj.org/article/937eeed544fb4764a51b1ba8906b06f2
Autor:
Yohann Bohbot, Jérôme Garot, Isabelle Danjon, Dominique Thébert, Louis Nahory, Philippe Gros, Fiorella Salerno, Philippe Garot
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionCardiac lymphoma is a rare but serious disease that is usually located in the right heart. The symptoms (dyspnea, respiratory distress, fatigue, syncope…) are not specific and depend on the mass location. Cardiac magnetic resonance has
Externí odkaz:
https://doaj.org/article/1fc0c612240849d1a34ff41c67e9facd
Autor:
Guoyue Xu, Rebekah van Bruggen, Christian O. Gualtieri, Neda Moradin, Adrien Fois, Diane Vallerand, Mariana De Sa Tavares Russo, Angelia Bassenden, Wenyun Lu, Mifong Tam, Sylvie Lesage, Hélène Girouard, Daina Zofija Avizonis, Geneviève Deblois, Josef T. Prchal, Mary Stevenson, Albert Berghuis, Tom Muir, Joshua Rabinowitz, Silvia M. Vidal, Nassima Fodil, Philippe Gros
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108170- (2020)
Summary: The replication cycle and pathogenesis of the Plasmodium malarial parasite involves rapid expansion in red blood cells (RBCs), and variants of certain RBC-specific proteins protect against malaria in humans. In RBCs, bisphosphoglycerate muta
Externí odkaz:
https://doaj.org/article/262bb3d083ec462590385e23ff946934
Autor:
Ida Derish, Jeremy K H Lee, Melanie Wong-King-Cheong, Sima Babayeva, Jillian Caplan, Vicki Leung, Chloe Shahinian, Michel Gravel, Michael R Deans, Philippe Gros, Elena Torban
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230586 (2020)
Planar cell polarity (PCP) pathway is crucial for tissue morphogenesis. Mutations in PCP genes cause multi-organ anomalies including dysplastic kidneys. Defective PCP signaling was postulated to contribute to cystogenesis in polycystic kidney disease
Externí odkaz:
https://doaj.org/article/d0d10d5b6870448ca8b551765abfa1f2
Autor:
Nassima Fodil, Neda Moradin, Vicki Leung, Jean-Frederic Olivier, Irena Radovanovic, Thiviya Jeyakumar, Manuel Flores Molina, Ashley McFarquhar, Romain Cayrol, Dominique Bozec, Naglaa H. Shoukry, Michiaki Kubo, Julia Dimitrieva, Edouard Louis, Emilie Theatre, Stephanie Dahan, Yukihide Momozawa, Michel Georges, Garabet Yeretssian, Philippe Gros
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Hook-related protein family member CCDC88b is encoded by a locus that has been associated with inflammatory bowel disease. Here the authors show that Ccdc88b inactivation in T cells prevents colitis in a transfer model, and detect high colonic levels
Externí odkaz:
https://doaj.org/article/1ef769869ff946e8995e6d2e8381e531
Autor:
Rajesh M Valanparambil, Mifong Tam, Pierre-Paul Gros, Jean-Philippe Auger, Mariela Segura, Philippe Gros, Armando Jardim, Timothy G Geary, Keiko Ozato, Mary M Stevenson
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006647 (2017)
Interferon regulatory factor-8 (IRF-8) is critical for Th1 cell differentiation and negatively regulates myeloid cell development including myeloid-derived suppressor cells (MDSC). MDSC expand during infection with various pathogens including the gas
Externí odkaz:
https://doaj.org/article/7ed5a4d98cc749188793e07309153a83
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177818 (2017)
Pyruvate kinase (PKLR) deficiency protects mice and humans against blood-stage malaria. Although mouse strain AcB62 carries a malaria-protective PklrI90N genetic mutation, it is phenotypically susceptible to blood stage malaria induced by infection w
Externí odkaz:
https://doaj.org/article/380c755e7c4b483abd726df43509b8f3
Autor:
Rebekah van Bruggen, Christian Gualtieri, Alexandra Iliescu, Chalisa Louicharoen Cheepsunthorn, Punchalee Mungkalasut, Jean-François Trape, David Modiano, Bienvenu Sodiomon Sirima, Pratap Singhasivanon, Mark Lathrop, Anavaj Sakuntabhai, Jean-François Bureau, Philippe Gros
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144555 (2015)
Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. We have shown that Pklr deficiency in mice reduces the severity (reduced parasitemia, increased survival) of blood stage malaria induced by
Externí odkaz:
https://doaj.org/article/066bc068100249c1b7b963152d67f5a1