Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes

Autor: Dodd, MS, Sousa Fialho, MDL, Montes Aparicio, CN, Kerr, M, Timm, KN, Griffin, JL, Luiken, JJFP, Glatz, JFC, Tyler, DJ, Heather, LC

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • HIF-1α is activated following myocardial infarction, and is a critical transcription factor promoting survival in hypoxia. • Type 2 diabetes blunts HIF-1α activation in ischemia and downstream adaptation to hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b03523fcf1d2ee305e6c87916135e75
http://europepmc.org/articles/PMC6115650

Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling

Autor: Alexander V. Zhdanov, Ruslan I. Dmitriev, Dmitri B. Papkovsky

Publikováno v: Bioscience Reports
Bioscience Reports, Vol 32, Iss 6 (2012)
BIOSCIENCE REPORTS

Mitochondrial uncoupling is implicated in many patho(physiological) states. Using confocal live cell imaging and an optical O2 sensing technique, we show that moderate uncoupling of the mitochondria with plecomacrolide Baf (bafilomycin A1) causes par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b572061200d79278790790cf8ab28758
https://doi.org/10.1042/bsr20120085

L3MBTL3 is induced by HIF-1α and fine tunes the HIF-1α degradation under hypoxia in vitro.

Autor: Wang M; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China., Wang D; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China., Lang Y; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China., Shao A; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China., Zhang R; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China., Tang J; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China., Lai D; Sun Yat-sen Memorial Hospital, Sun Yat-sen University, NO. 107, Yanjiangxi Road, Guangzhou, 510120, China., Xiao C; National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.

Publikováno v: Heliyon [Heliyon] 2023 Jan 24; Vol. 9 (2), pp. e13222. Date of Electronic Publication: 2023 Jan 24 (Print Publication: 2023).