Mycobacterium tuberculosis VII secretion system effector molecule Rv2347c blocks the maturation of phagosomes and activates the STING/TBK1 signaling pathway to inhibit cell autophagy.

Autor: Jiang Z; Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, China., Zhen J; Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, China., Abulikena Y; Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, China., Gao C; Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, China., Huang L; Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, China., Huang T; Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, China., Xie J; Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, China.

Publikováno v: Microbiology spectrum [Microbiol Spectr] 2024 Nov 05; Vol. 12 (11), pp. e0118824. Date of Electronic Publication: 2024 Sep 23.

Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes.

Autor: Wogram E; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany., Sümpelmann F; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Dong W; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; The Institute for Chemistry, Engineering & Medicine for Human Health (Sarafan ChEM-H), Stanford University, Stanford, CA 94305, USA., Rawat E; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; The Institute for Chemistry, Engineering & Medicine for Human Health (Sarafan ChEM-H), Stanford University, Stanford, CA 94305, USA., Fernández Maestre I; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Fu D; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Braswell B; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Khalil A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; The Wyss Institute for Biologically Inspired Engineering, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Boston, MA 02134, USA., Buescher JM; Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg, Germany., Mittler G; Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg, Germany., Borner GHH; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried 82152, Germany., Vlachos A; Department of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany., Tholen S; Institute of Surgical Pathology, Medical Center, University of Freiburg, 79106 Freiburg, Germany., Schilling O; Institute of Surgical Pathology, Medical Center, University of Freiburg, 79106 Freiburg, Germany., Bell GW; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Rambold AS; Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg, Germany., Akhtar A; Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg, Germany., Schnell O; Department of Neurosurgery, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany., Beck J; Department of Neurosurgery, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany., Abu-Remaileh M; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; The Institute for Chemistry, Engineering & Medicine for Human Health (Sarafan ChEM-H), Stanford University, Stanford, CA 94305, USA., Prinz M; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany; BIOSS Centre for Biological Signalling Studies and Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, 79104 Freiburg, Germany., Jaenisch R; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address: jaenisch@wi.mit.edu.

Publikováno v: Immunity [Immunity] 2024 Sep 10; Vol. 57 (9), pp. 2216-2231.e11. Date of Electronic Publication: 2024 Aug 15.

Human GBP1 Is Involved in the Repair of Damaged Phagosomes/Endolysosomes.

Autor: Buijze, Hellen¹ (AUTHOR), Brinkmann, Volker² (AUTHOR), Hurwitz, Robert³ (AUTHOR), Dorhoi, Anca^4,5 (AUTHOR), Kaufmann, Stefan H. E.^1,6,7 (AUTHOR), Pei, Gang⁴ (AUTHOR) gang.pei@fli.de

Publikováno v: International Journal of Molecular Sciences. Jun2023, Vol. 24 Issue 11, p9701. 19p.

A PI(3,5)P2 reporter reveals PIKfyve activity and dynamics on macropinosomes and phagosomes.

Autor: Vines JH; School of Biosciences, University of Sheffield, Firth Court Western Bank, Sheffield, UK., Maib H; Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK., Buckley CM; School of Biosciences, University of Sheffield, Firth Court Western Bank, Sheffield, UK., Gueho A; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland., Zhu Z; School of Biosciences, University of Sheffield, Firth Court Western Bank, Sheffield, UK., Soldati T; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland., Murray DH; Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK., King JS; School of Biosciences, University of Sheffield, Firth Court Western Bank, Sheffield, UK.

Publikováno v: The Journal of cell biology [J Cell Biol] 2023 Sep 04; Vol. 222 (9). Date of Electronic Publication: 2023 Jun 29.

In Vivo Trapping of Latex Bead Phagosomes for Quantitative Force Measurements.

Autor: Sanghavi P; Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India. paulomi.sanghavi@tifr.res.in., Rai A; Department of Molecular Life Sciences, University of Zurich, Zürich, Switzerland., Mallik R; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2623, pp. 187-200.