The HIV-1 accessory protein Nef increases surface expression of the checkpoint receptor Tim-3 in infected CD4+ T cells

Autor: Jimmy D. Dikeakos, Cassandra R Edgar, Andrés Finzi, S. M. Mansour Haeryfar, Alexa Galbraith, Jérémie Prévost, Mitchell J. Mumby, Rajesh Abraham Jacob, Frank Kirchhoff, Antony Lurie, Steven M. Trothen

Publikováno v: The Journal of Biological Chemistry

Prolonged immune activation drives the upregulation of multiple checkpoint receptors on the surface of virus-specific T cells, inducing their exhaustion. Reversing HIV-1-induced T cell exhaustion is imperative for efficient virus clearance; however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4498fbba12fc0bc9e4265261297f405
http://europepmc.org/articles/PMC8390549

Effective Anti–SARS-CoV-2 Immune Response in Patients With Clonal Mast Cell Disorders

Autor: Julien Rossignol, Amani Ouedrani, Cristina Bulai Livideanu, Stéphane Barete, Louis Terriou, David Launay, Richard Lemal, Celine Greco, Laurent Frenzel, Cecile Meni, Christine Bodemere-Skandalis, Laura Polivka, Anne-Florence Collange, Hassiba Hachichi, Sonia Bouzourine, Djazira Nait Messaoud, Mathilde Negretto, Laurence Vendrame, Marguerite Jambou, Marie Gousseff, Stéphane Durupt, Jean-Christophe Lega, Jean-Marc Durand, Caroline Gaudy, Gandhi Damaj, Marie-Pierre Gourin, Mohamed Hamidou, Laurence Bouillet, Edwige Le Mouel, Alexandre Maria, Patricia Zunic, Quentin Cabrera, Denis Vincent, Christian Lavigne, Etienne Riviere, Clement Gourguechon, Marie Courbebaisse, David Lebeaux, Béatrice Parfait, Gérard Friedlander, Anne Brignier, Ludovic Lhermitte, Thierry Jo Molina, Julie Bruneau, Julie Agopian, Patrice Dubreuil, Dana Ranta, Alexandre Mania, Michel Arock, Isabelle Staropoli, Olivier Tournilhac, Olivier Lortholary, Olivier Schwartz, Lucienne Chatenoud, Olivier Hermine

Publikováno v: The Journal of Allergy and Clinical Immunology. in Practice
The Journal of Allergy and Clinical Immunology: In Practice
The Journal of Allergy and Clinical Immunology: In Practice, 2022, 10 (5), pp.1356-1364.e2. ⟨10.1016/j.jaip.2021.12.038⟩
The Journal of Allergy and Clinical Immunology: In Practice, American Academy of Allergy, Asthma & Immunology, 2022, 10 (5), pp.1356-1364.e2. ⟨10.1016/j.jaip.2021.12.038⟩

International audience; BackgroundMast cells are key players in innate immunity and the TH2 adaptive immune response. The latter counterbalances the TH1 response, which is critical for antiviral immunity. Clonal mast cell activation disorders (cMCADs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04db6ca827df444d957deee818b02101
https://doi.org/10.1016/j.jaip.2021.12.038

Redox environment in stem and differentiated cells: A quantitative approach

Autor: Yu.A. Kaulin, N. A. Pugovkina, Alla N. Shatrova, I. A. Gamaley, Nikolay Nikolsky, V. V. Zenin, Olga G. Lyublinskaya, Z. V. Kovaleva, I. V. Kozhukharova, Nikolai D. Aksenov, Ju. S. Ivanova

Publikováno v: Redox Biology
Redox Biology, Vol 12, Iss, Pp 758-769 (2017)

Stem cells are believed to maintain a specific intracellular redox status through a combination of enhanced removal capacity and limited production of ROS. In the present study, we challenge this assumption by developing a quantitative approach for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1276b0b45a019fab35fe62a9d7ed304b
http://europepmc.org/articles/PMC5393314

Hypomorphic function and somatic reversion of DOCK8 cause combined immunodeficiency without hyper-IgE

Autor: Edward Blair, Smita Y. Patel, K Thomson, Jenny C. Taylor, John Taylor, Shelley Segal, Charlotte Noakes, Berne Ferry, Ross Sadler, Anne-Kathrin Kienzler, Richa U. Sharma, Helen Chapel, Pauline A. van Schouwenburg, Ishita Marwah

Publikováno v: Clinical Immunology (Orlando, Fla.)

Loss-of-function mutations in DOCK8 are linked to hyper-IgE syndrome. Patients typically present with recurrent sinopulmonary infections, severe cutaneous viral infections, food allergies and elevated serum IgE. Although patients may present with a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a6417af9313db61101a975ed73511b
http://europepmc.org/articles/PMC4758821

T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones

Autor: Sarah M, Theaker, Cristina, Rius, Alexander, Greenshields-Watson, Angharad, Lloyd, Andrew, Trimby, Anna, Fuller, John J, Miles, David K, Cole, Mark, Peakman, Andrew K, Sewell, Garry, Dolton

Publikováno v: Journal of Immunological Methods

Isolation of peptide-specific T-cell clones is highly desirable for determining the role of T-cells in human disease, as well as for the development of therapies and diagnostics. However, generation of monoclonal T-cells with the required specificity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f93d9ebd336e4fada1cd22ead8e9c5ce
https://pubmed.ncbi.nlm.nih.gov/26826277