Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways

Autor: F-F Chen, Roger B. Dodd, Gerold Schmitt-Ulms, PH St George-Hyslop, Yi Li, Seema Qamar, Christopher Bohm, Jean Sevalle, Paul E. Fraser

Publikováno v: Molecular and Cellular Neurosciences

Inherited variants in multiple different genes are associated with increased risk for Alzheimer's disease (AD). In many of these genes, the inherited variants alter some aspect of the production or clearance of the neurotoxic amyloid β-peptide (Aβ)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc080f87770d972e8594c14790c4a94

Thirteenth meeting of the European Neurological Society 14–18June 2003,Istanbul, Turkey

Autor: T. Kawarai, S Merlo, Guglielmo Bernardi, Antonio Orlacchio, Ph St George Hyslop, Antonio Totaro

Publikováno v: Journal of Neurology. 250:II1-II211

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e80a3efcc28ec40192dc306258ab9fd5
https://doi.org/10.1007/bf03160427

Mutation of the ALS-/FTD-Associated RNA-Binding Protein FUS Affects Axonal Development.

Autor: van Tartwijk FW; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom., Wunderlich LCS; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom., Mela I; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom., Makarchuk S; Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge CB2 OAH, United Kingdom., Jakobs MAH; Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom., Qamar S; Department of Clinical Neurosciences, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom., Franze K; Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom., Kaminski Schierle GS; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom., St George-Hyslop PH; Department of Clinical Neurosciences, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.; Department of Medicine, University of Toronto and University Health Network and Tanz Centre for Research in Neurodegenerative Diseases University of Toronto, Toronto, Ontario M5T 0S8, Canada.; Department of Neurology, Taub Institute For Research on Alzheimer's Disease and the Aging Brain, Columbia University Irvine Medical Center, New York, New York 10032., Lin JQ; Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge CB2 OAH, United Kingdom.; UK Dementia Research Institute Centre and Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London SE5 9NU, United Kingdom., Holt CE; Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom., Kaminski CF; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom cfk23@cam.ac.uk.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Jul 03; Vol. 44 (27). Date of Electronic Publication: 2024 Jul 03.

Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice.

Autor: Audrain M; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Haure-Mirande JV; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Mleczko J; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Wang M; Department of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Griffin JK; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., St George-Hyslop PH; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Fraser P; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Zhang B; Department of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Gandy S; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; National Institute on Aging-Designated Alzheimer's Disease Research Center and Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Research and Development, James J. Peters Veterans Affairs Medical Center, Bronx, New York, USA., Ehrlich ME; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2021 Feb; Vol. 17 (2), pp. 149-163. Date of Electronic Publication: 2020 Dec 12.

Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.

Autor: Audrain M; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Haure-Mirande JV; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Wang M; Department of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Kim SH; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Fanutza T; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Chakrabarty P; Department of Neuroscience and McKnight Brain Institute, University of Florida, Gainesville, FL, 32610, USA., Fraser P; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., St George-Hyslop PH; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Golde TE; Department of Neuroscience and McKnight Brain Institute, University of Florida, Gainesville, FL, 32610, USA., Blitzer RD; Departments of Pharmacological Sciences and Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Schadt EE; Department of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Zhang B; Department of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Ehrlich ME; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. michelle.ehrlich@mssm.edu.; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. michelle.ehrlich@mssm.edu., Gandy S; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. samuel.gandy@mssm.edu.; Department of Psychiatry and Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. samuel.gandy@mssm.edu.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2019 Sep; Vol. 24 (9), pp. 1383-1397. Date of Electronic Publication: 2018 Oct 03.