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pro vyhledávání: '"PH, Pleckstrin Homology"'
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Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 169-180 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Primary cilium is a microtubule-based organelle that projects from the surfaces of most mammalian cell types and protrudes into the extracellular milieu as an antenna-like sensor to senses extracellular physical and biochemical signals, and then tran
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 29, Iss, Pp 101218-(2022)
Biochemistry and Biophysics Reports, Vol 29, Iss, Pp 101218-(2022)
Purpose The objective of this study is to validate the existence of dual cores within the typical phosphotyrosine binding (PTB) domain and to identify potentially damaging and pathogenic nonsynonymous coding single nuclear polymorphisms (nsSNPs) in t
Publikováno v:
The Journal of Biological Chemistry
As a central player in the canonical TGF-β signaling pathway, Smad2 transmits the activation of TGF-β receptors at the plasma membrane (PM) to transcriptional regulation in the nucleus. Although it has been well established that binding of TGF-β t
Autor:
Andrea Papdine Morovicz, Sandra Ninzima, Diana Cornelia Turcu, Malene Skuseth Slinning, Clive D'Santos, Aurélia E. Lewis, Fatemeh Mazloumi Gavgani, Victoria Smith Arnesen
Publikováno v:
Molecular & Cellular Proteomics : MCP
Molecular & Cellular Proteomics
Molecular & Cellular Proteomics
Polyphosphoinositides (PPIns) play essential roles as lipid signaling molecules, and many of their functions have been elucidated in the cytoplasm. However, PPIns are also intranuclear where they contribute to chromatin remodeling, transcription, and
Autor:
Juan Darío Ortigoza-Escobar, Norito Tamura, Asako Goto, Kentaro Hanada, Shota Sakai, Roser Colomé, Aya Mizuike, Loreto Martorell
Publikováno v:
The Journal of Biological Chemistry
The lipid molecule ceramide is transported from the endoplasmic reticulum to the Golgi apparatus for sphingomyelin production via the ceramide transport protein (CERT), encoded by CERT1. Hyperphosphorylation of CERT's serine-repeat motif (SRM) decrea
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3692-3707 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3692-3707 (2021)
Graphical abstract
Highlights • YPIBP contains 679 PI-binding yeast proteins and their PI-binding evidence. • YPIBP contains 181 lipid-binding domains and 103 lipid-related domains. • YPIBP provides PI-binding enrichment analysis and domai
Highlights • YPIBP contains 679 PI-binding yeast proteins and their PI-binding evidence. • YPIBP contains 181 lipid-binding domains and 103 lipid-related domains. • YPIBP provides PI-binding enrichment analysis and domai
Autor:
Nada Bulus, Charles R. Sanders, Ambra Pozzi, Glenda Mernaugh, Anika Böttcher, Xinyu Dong, Reinhard Fässler, Roy Zent, Kyle L. Brown
Publikováno v:
Journal of Biological Chemistry
The Journal of Biological Chemistry
J. Biol. Chem. 296:100361 (2021)
The Journal of Biological Chemistry
J. Biol. Chem. 296:100361 (2021)
Integrin-linked kinase (ILK), a central component of the intracellular ILK–pinch–parvin complex, localizes together with paxillin to focal adhesions and regulates integrin-mediated cell functions. ILK was initially misclassified as a kinase based
Autor:
Raju V. S. Rajala
Publikováno v:
Journal of Lipid Research, Vol 62, Iss, Pp 100041-(2021)
Journal of Lipid Research
Journal of Lipid Research
The field of phosphoinositide signaling has expanded significantly in recent years. Phosphoinositides (also known as phosphatidylinositol phosphates or PIPs) are universal signaling molecules that directly interact with membrane proteins or with cyto
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 24, Iss, Pp 100808-(2020)
Biochemistry and Biophysics Reports, Vol 24, Iss, Pp 100808-(2020)
Diacylglycerol kinase δ (DGKδ) is a type II DGK, which catalyzes diacylglycerol phosphorylation to produce phosphatidic acid. DGKδ is expressed in several types of tissues and organs including the stomach, testis, bone marrow, and lymph node. Here