Výsledky vyhledávání - "PG, phosphatidylglycerol"

Docosahexaenoic acid-containing phosphatidic acid interacts with clathrin coat assembly protein AP180 and regulates its interaction with clathrin

Autor: Fumio Sakane, Fumi Hoshino

Publikováno v: Biochemical and Biophysical Research Communications

The clathrin coat assembly protein AP180 drives endocytosis, which is crucial for numerous physiological events, such as the internalization and recycling of receptors, uptake of neurotransmitters and entry of viruses, including SARS-CoV-2, by intera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486bafc8e128e9f14b907481315a7d43
https://doi.org/10.1016/j.bbrc.2021.11.097

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Lipid analysis by ion mobility spectrometry combined with mass spectrometry: A brief update with a perspective on applications in the clinical laboratory

Autor: Joshua Dubland

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab
Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 23, Iss, Pp 7-13 (2022)

Ion mobility spectrometry (IMS) is an analytical technique where ions are separated in the gas phase based on their mobility through a buffer gas in the presence of an electric field. An ion passing through an IMS device has a characteristic collisio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae14ffaafac42c15bc615e2dc76a45d
http://europepmc.org/articles/PMC8703053

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Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging

Autor: Lu Tian, Wanfang Li, Jinfeng Wei, Zhi Zhou, Yanhua Chen, Zhonghua Wang, Wenqing Fu, Yaqi Liu, Baili Wang, Bingshu He, Meiling Huo, Jianzhen Xia, Zeper Abliz

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3665-3677 (2021)
Acta Pharmaceutica Sinica. B

Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy (DN) is vital for more accurate understanding the molecular pathological signature and developing novel therapeutic strategies. In the present study, a spatial-reso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e36a0724bd8a167963aba4a72cb2332
http://www.sciencedirect.com/science/article/pii/S2211383521001799

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Metabolomic and lipidomic characterization of an X-chromosome deletion disorder in neural progenitor cells by UHPLC-HRMS

Autor: Richard A. Yost, Vanessa Y. Rubio, Hoda Safari Yazd, Timothy J. Garrett, Casey A. Chamberlain

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 20, Iss, Pp 11-24 (2021)
Journal of Mass Spectrometry and Advances in the Clinical Lab

Highlights • LC-HRMS Metabolomics and lipidomics applied in X-chromosome deletion disorders. • Partial or complete deletion of the X chromosome is a very rare condition. • Neural progenitor cells from a patient with a 7.3 megabase deletion at X

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09943261b4913c7a499e6c4602a9449
http://www.sciencedirect.com/science/article/pii/S2667145X21000092

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The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface

Autor: Dianfan Li, Bowei Yang, Hebang Yao, Zhenfeng Liu

Publikováno v: Current Research in Structural Biology, Vol 3, Iss, Pp 312-323 (2021)
Current Research in Structural Biology

Phosphatidylglycerol is a crucial phospholipid found ubiquitously in biological membranes of prokaryotic and eukaryotic cells. The phosphatidylglycerol phosphate (PGP) synthase (PgsA), a membrane-embedded enzyme, catalyzes the primary reaction of pho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43968c1a1e3f3f8bc79ed66d9b462fc
http://www.sciencedirect.com/science/article/pii/S2665928X21000283

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In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging

Autor: Zhonghua Wang, Zeper Abliz, Meiling Huo, Chunyan Yang, Bingshu He, Wenqing Fu, Yaqi Liu, Jinfeng Wei

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 6, Pp 1083-1093 (2020)
Acta Pharmaceutica Sinica. B

Understanding of the nephrotoxicity induced by drug candidates is vital to drug discovery and development. Herein, an in situ metabolomics method based on air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e79605efb06e65af3a2ee9300ab4fcf
http://www.sciencedirect.com/science/article/pii/S2211383519310718

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Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to HepatosteatosisSummary

Autor: Dan Xu, Jia Nie, Feng Liu, Dandan Jia, Yue Zheng, Xianlin Han, Xueling Liu, Jun Zhang, Xiaoyang Zhang, Jianing Wang, Haoran Sun, Yuguang Shi

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 763-781 (2019)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Obesity promotes the development of nonalcoholic fatty liver diseases (NAFLDs), yet not all obese patients develop NAFLD. The underlying causes for this discrepancy remain elusive. LPGAT1 is an acyltransferase that catalyzes the rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5358bb0e49578b38ed9658eda93c328c
http://www.sciencedirect.com/science/article/pii/S2352345X19300116

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A promiscuous archaeal cardiolipin synthase enables construction of diverse natural and unnatural phospholipids

Autor: Ruben L. H. Andringa, Adriaan J. Minnaard, Marten Exterkate, Niels H. J. Wolbert, Niels A W de Kok, Arnold J. M. Driessen

Publikováno v: The Journal of Biological Chemistry, 296:100691. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
The Journal of Biological Chemistry

Cardiolipins (CL) are a class of lipids involved in the structural organization of membranes, enzyme functioning, and osmoregulation. Biosynthesis of CLs has been studied in eukaryotes and bacteria, but has been barely explored in archaea. Unlike the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19748282c2576fd1016b3a68ef4603df
https://hdl.handle.net/11370/338edff5-062f-40da-a1c5-617a8657e762

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Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site

Autor: Marijke Brams, Diletta Pasini, Akshay Sridhar, Chris Ulens, Sarah C. R. Lummis, Kumiko Kambara, Rebecca J. Howard, Aujan Mehregan, Erik Lindahl, Daniel Bertrand

Publikováno v: The Journal of Biological Chemistry
Journal of Biological Chemistry

Pentameric ligand-gated ion channels (pLGICs) are crucial mediators of electrochemical signal transduction in various organisms from bacteria to humans. Lipids play an important role in regulating pLGIC function, yet the structural bases for specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b160ea3186d551ffde4ccf17635eb8
http://europepmc.org/articles/PMC8327344

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