Zobrazeno 1 - 10
of 53
pro vyhledávání: '"PETER J. WEST"'
Autor:
Danielle M. Giangrasso, Kaliana M. Veros, Maureen M. Timm, Peter J. West, Karen S. Wilcox, Kristen A. Keefe
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The shift from drug abuse to addiction is considered to arise from the transition between goal-directed and habitual control over drug behavior. Habitual responding for appetitive and skill-based behaviors is mediated by potentiated glutamate signali
Externí odkaz:
https://doaj.org/article/bec789625f6e4497aecb95f50191491e
Autor:
Cameron S. Metcalf, Fabiola Vanegas, Tristan Underwood, Kristina Johnson, Peter J. West, Misty D. Smith, Karen S. Wilcox
Publikováno v:
Epilepsia Open, Vol 7, Iss 1, Pp 46-58 (2022)
Abstract Objective Infection with Theiler's murine encephalomyelitis virus (TMEV) in C57Bl/6J mice results in handling‐induced seizures and is useful for evaluating compounds effective against infection‐induced seizures. However, to date only a f
Externí odkaz:
https://doaj.org/article/a76e77e844774fddb5f6adb1f50150ea
Autor:
Segewkal H. Heruye, Ted J. Warren, Joseph A. Kostansek IV, Samantha B. Draves, Stephanie A. Matthews, Peter J. West, Kristina A. Simeone, Timothy A. Simeone
Publikováno v:
Nutrients, Vol 14, Iss 3, p 613 (2022)
Ascorbic acid (AA; a.k.a. vitamin C) is well known for its cellular protection in environments of high oxidative stress. Even though physiological concentrations of AA in the brain are significant (0.2–10 mM), surprisingly little is known concernin
Externí odkaz:
https://doaj.org/article/e8d2e842167c44618873d46319685bb4
Autor:
Gregory J. Remigio, Jaycie L. Loewen, Sage Heuston, Colin Helgeson, H. Steve White, Karen S. Wilcox, Peter J. West
Publikováno v:
Neurobiology of Disease, Vol 105, Iss , Pp 221-234 (2017)
Memory deficits have a significant impact on the quality of life of patients with epilepsy and currently no effective treatments exist to mitigate this comorbidity. While these cognitive comorbidities can be associated with varying degrees of hippoca
Externí odkaz:
https://doaj.org/article/744c4666764d4710ac43a3d5157cc44d
Autor:
Anthony D. Umpierre, Gregory J. Remigio, E. Jill Dahle, Kate Bradford, Anitha B. Alex, Misty D. Smith, Peter J. West, H. Steve White, Karen S. Wilcox
Publikováno v:
Neurobiology of Disease, Vol 64, Iss , Pp 98-106 (2014)
Viral infection of the CNS can result in encephalitis and acute seizures, increasing the risk for later-life epilepsy. We have previously characterized a novel animal model of temporal lobe epilepsy that recapitulates key sequela in the development o
Externí odkaz:
https://doaj.org/article/c566a8738c03434488f52f5e144d22ec
Autor:
Misty D. Smith, Karen S. Wilcox, Fabiola Vanegas, Kristina Johnson, Cameron S. Metcalf, Peter J. West, Tristan K. Underwood
Publikováno v:
Epilepsia Open. 7:46-58
Objective Infection with Theiler's Murine Encephalomyelitis Virus (TMEV) in C57Bl/6J mice results in handling-induced seizures and is useful for evaluating compounds effective against infection-induced seizures. However, to date only a few compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6642090f6d845d14bfae765756b9f109
https://doi.org/10.1002/epi4.12550
https://doi.org/10.1002/epi4.12550
Autor:
Kyle E. Thomson, Sharon F. Edwards, Jennifer Huff, Cameron S. Metcalf, Thomas G. Newell, Karen S. Wilcox, Peter J. West
Publikováno v:
Epilepsia
Objective Approximately 30% of patients with epilepsy do not experience full seizure control on their antiseizure drug (ASD) regimen. Historically, screening for novel ASDs has relied on evaluating efficacy following a single administration of a test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5278c3101fbb629e22671ae8afe7e221
https://doi.org/10.1111/epi.16531
https://doi.org/10.1111/epi.16531
Autor:
Segewkal H. Heruye, Ted J. Warren, Joseph A. Kostansek IV, Samantha B. Draves, Stephanie A. Matthews, Peter J. West, Kristina A. Simeone, Timothy A. Simeone
Publikováno v:
Nutrients, Vol 14, Iss 613, p 613 (2022)
Nutrients; Volume 14; Issue 3; Pages: 613
Nutrients; Volume 14; Issue 3; Pages: 613
Ascorbic acid (AA; a.k.a. vitamin C) is well known for its cellular protection in environments of high oxidative stress. Even though physiological concentrations of AA in the brain are significant (0.2–10 mM), surprisingly little is known concernin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53254f19840cd0f0b00ffd8aea8efe9d
https://pubmed.ncbi.nlm.nih.gov/35276972
https://pubmed.ncbi.nlm.nih.gov/35276972
Autor:
Cameron S. Metcalf, Misty D. Smith, Gerald W. Saunders, Kyle E. Thomson, Carlos B. Rueda, Timothy H. Pruess, Karen S. Wilcox, Peter J. West, Peggy Billingsley
Publikováno v:
Experimental neurology. 349
The discovery and development of novel antiseizure drugs (ASDs) that are effective in controlling pharmacoresistant spontaneous recurrent seizures (SRSs) continues to represent a significant unmet clinical need. The Epilepsy Therapy Screening Program
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94723747667f83d018362a9d37427c43
https://pubmed.ncbi.nlm.nih.gov/34922908
https://pubmed.ncbi.nlm.nih.gov/34922908
Autor:
Peter J. West, E. J. Dahle, Kristina Johnson, Karen S. Wilcox, Chelsea D. Pernici, Spink A, Cameron S. Metcalf
Dravet syndrome (DS) is a rare childhood epilepsy disorder resulting in spontaneous, recurrent seizures (SRS) and behavioral co-morbidities. To facilitate the discovery and development of anti-seizure drugs for DS, the contract site of the NINDS Epil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3096dc9035fdfee6ca59264524de92a
https://doi.org/10.1101/2021.06.16.448684
https://doi.org/10.1101/2021.06.16.448684
