Zobrazeno 1 - 10
of 139
pro vyhledávání: '"PETER H. FISHMAN"'
Autor:
Peter H. Fishman, Julie A. Meeks, Karl Maki, John K. Northup, R. Victor Rebois, Terence E. Hébert
Publikováno v:
Cellular Signalling. 24:2051-2060
β-Adrenergic receptors (βAR) and D(2)-like dopamine receptors (which include D(2)-, D(3)- and D(4)-dopamine receptors) activate G(s) and G(i), the stimulatory and inhibitory heterotrimeric G proteins, respectively, which in turn regulate the activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f8825c5749a50ef1fc96dbcd7a3953
https://doi.org/10.1016/j.cellsig.2012.06.011
https://doi.org/10.1016/j.cellsig.2012.06.011
Publikováno v:
Journal of Neurochemistry. 47:213-222
Binding of tetanus toxin to rat brain membranes was of lower affinity and capacity when binding was determined in 150 mM NaCl, 50 mM Tris-HCl (pH 7.4) than in 25 mM Tris-acetate (pH 6.0). Binding under both conditions was reduced by treating the memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523491bf8f09768efe896a4e922b0069
https://doi.org/10.1111/j.1471-4159.1986.tb02852.x
https://doi.org/10.1111/j.1471-4159.1986.tb02852.x
Autor:
Peter H. Fishman, Wei Liang
Publikováno v:
Journal of Biological Chemistry. 279:46882-46889
Down-regulation is a classic response of most G protein-coupled receptors to prolonged agonist stimulation. We recently showed that when expressed in baby hamster kidney cells, the human β1-but not the β2-adrenergic receptor (AR) is totally resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9a7394e35500e5dd8549f3b83247243
https://doi.org/10.1074/jbc.m406501200
https://doi.org/10.1074/jbc.m406501200
Publikováno v:
Journal of Biological Chemistry. 278:39773-39781
Prolonged agonist stimulation results in down-regulation of most G protein-coupled receptors. When we exposed baby hamster kidney cells stably expressing the human beta1-adrenergic receptor (beta 1AR) to agonist over a 24-h period, we instead observe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ea967229ae1104245723668201440d0
https://doi.org/10.1074/jbc.m304482200
https://doi.org/10.1074/jbc.m304482200
Publikováno v:
Biochemistry. 41:8019-8030
Prolonged agonist exposure often induces downregulation of G protein-coupled receptors (GPCRs). Although downregulation of the prototypical beta(2)-adrenergic receptor (beta(2)AR) has been extensively studied, the underlying mechanisms have yet to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def4e899e0a1b51560f3fae2e228c6a3
https://doi.org/10.1021/bi025538r
https://doi.org/10.1021/bi025538r
Publikováno v:
Journal of Neurochemistry. 77:823-829
We investigated the regulation of β2-adrenergic receptors (β2AR) by protein kinase C (PKC) in rat C6 glioma cells at the levels of receptor activity, protein expression and gene expression. Cells exposed to 4β-phorbol-12-myristate-13-acetate (PMA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfae42f63a121512d99deced0ef8654c
https://doi.org/10.1046/j.1471-4159.2001.00279.x
https://doi.org/10.1046/j.1471-4159.2001.00279.x
Autor:
John D. Alvaro, Patricia K. Curran, Peter H. Fishman, Ronald S. Duman, Ginger A. Hoffman, Curtis A. Machida, Philip A. Iredale, Laura Rydelek Fitzgerald, Zhongwei Li, Vidita A. Vaidya, Richard Hsu
Publikováno v:
Europe PubMed Central
In the current study, we investigated the mechanism by which protein kinase C (PKC) regulates the expression of beta1-adrenergic receptor (beta1AR) mRNA in rat C6 glioma cells. Exposure of the cells to 4beta-phorbol-12-myristate-13-acetate (PMA), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a5d681d0f68021937eeb2291e4542c
https://doi.org/10.1124/mol.54.1.14
https://doi.org/10.1124/mol.54.1.14
Autor:
Peter H. Fishman, Palmer A. Orlandi
Publikováno v:
The Journal of Cell Biology
The mechanism by which cholera toxin (CT) is internalized from the plasma membrane before its intracellular reduction and subsequent activation of adenylyl cyclase is not well understood. Ganglioside GM1, the receptor for CT, is predominantly cluster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3178c1d2b8bfb2e2e7dad25768b100
https://doi.org/10.1083/jcb.141.4.905
https://doi.org/10.1083/jcb.141.4.905
Autor:
Peter H. Fishman, Michael D. Pak
Publikováno v:
Journal of Receptors and Signal Transduction. 16:1-23
CGP 12177A originally was developed as a hydrophilic antagonist to detect cell surface β1- and β2-adrenergic receptors, and sub-sequently was found to be a partial agonist for the atypical or β3-adrenergic receptor. Using hamster cells stably expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc59e51a705ace1f20b15bbc266d44c8
https://doi.org/10.3109/10799899609039938
https://doi.org/10.3109/10799899609039938
Autor:
Peter H. Fishman, Palmer A. Orlandi
Publikováno v:
Journal of Biological Chemistry. 268:17038-17044
Cholera toxin (CT) consists of a pentameric B subunit that binds to specific cell surface receptors identified as ganglioside GM1 and an A subunit that activates adenylylcyclase. The A subunit consists of A1 and A2 peptides linked by a disulfide bond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2816abf067ee84ede0825a471353ab75
https://doi.org/10.1016/s0021-9258(19)85298-5
https://doi.org/10.1016/s0021-9258(19)85298-5