Methacholine and PDGF activate store-operated calcium entry in neuronal precursor cells via distinct calcium entry channels

Autor: PAUL CUDDON, MARTIN D BOOTMAN, GILLIAN R RICHARDS, ALISON J SMITH, PETER B SIMPSON, H LLEWELYN RODERICK

Publikováno v: Biological Research, Vol 41, Iss 2, Pp 183-195 (2008)

Neurons are a diverse cell type exhibiting hugely different morphologies and neurotransmitter specifications. Their distinctive phenotypes are established during differentiation from pluripotent precursor cells. The signalling pathways that specify t

Externí odkaz: https://doaj.org/article/5b2950a7db644d21b4067656dd054e83

Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumour drug accumulation and limiting bioavailability and toxicity in normal tissues

Autor: Sally A. Peyman, Malcolm Haddrick, William Townley, Michael Fairclough, Elizabeth M. A. Valleley, Nicola Ingram, Antonia Wierzbicki, Richard J. Bushby, Radwa H. Abou-Saleh, Stephen D. Evans, Pamela F. Jones, Gemma Marston, Darren Treanor, Milene Volpato, Antonia Charalambous, Juliana Maynard, Neil H. Thomson, Laura E. McVeigh, J. Anthony Evans, Jorge L Jimenez-Macias, A Wright, P. Louise Coletta, Peter B Simpson, Benjamin R. G. Johnson, Steven Freear, Alexander F. Markham, James R. McLaughlan, Paul M. Loadman

Publikováno v: Fairclough, M 2020, ' Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumour drug accumulation and limiting bioavailability and toxicity in normal tissues ', Theranostics, vol. 10, no. 4 . https://doi.org/10.7150/thno.49670
Ingram, N, McVeigh, L E, Abou-Saleh, R H, Maynard, J, Peyman, S A, McLaughlan, J R, Fairclough, M, Marston, G, Valleley, E M A, Jimenez-Macias, J L, Charalambous, A, Townley, W, Haddrick, M, Wierzbicki, A, Wright, A, Volpato, M, Simpson, P B, Treanor, D E, Thomson, N H, Loadman, P M, Bushby, R J, Johnson, B R G, Jones, P F, Evans, J A, Freear, S, Markham, A F, Evans, S D & Coletta, P L 2020, ' Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues ', Theranostics, vol. 10, no. 24, pp. 10973-10992 . https://doi.org/10.7150/thno.49670
Theranostics

Most cancer patients receive chemotherapy at some stage of their treatment which makes improving the efficacy of cytotoxic drugs an ongoing and important goal. Despite large numbers of potent anti-cancer agents being developed, a major obstacle to cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8743562efc9f20857e1d1305e425ca8f
https://www.research.manchester.ac.uk/portal/en/publications/ultrasoundtriggered-therapeutic-microbubbles-enhance-the-efficacy-of-cytotoxic-drugs-by-increasing-circulation-and-tumour-drug-accumulation-and-limiting-bioavailability-and-toxicity-in-normal-tissues(d99d292e-9ff7-4039-a343-5bfeafca0d06).html

What makes a drug discovery consortium successful?

Autor: Peter B, Simpson, Graeme F, Wilkinson

Publikováno v: Nature reviews. Drug discovery. 19(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81545588153e3ef5973087de7f1ea7c7
https://pubmed.ncbi.nlm.nih.gov/32350459

Organ-on-a-chip technology: turning its potential for clinical benefit into reality

Autor: Malcolm Haddrick, Peter B. Simpson

Publikováno v: Drug discovery today. 24(5)

Organs-on-a-chip (OOAC) are research platforms containing cellular models designed to recapitulate relevant biological cues and, in some cases, enable communication between 'on-chip' connected organs. With enhanced physiological relevance, improvemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4301690a1ba86f8c3bea62416b66f4de
https://pubmed.ncbi.nlm.nih.gov/30880172

Implementation of a High Specification Dual-Arm Robotic Platform to Meet Flexible Screening Needs

Autor: Clare Leech, Kevin W. Moore, Robert J. Newman, Peter B. Simpson, Karen Allison, Jo Coulson, Grace K.Y. Chan

Publikováno v: JALA: Journal of the Association for Laboratory Automation. 12:115-123

The need for a high degree of flexibility within compound screening is a requirement throughout the drug discovery industry. The demands made of automation technology are becoming increasingly sophisticated as assay formats diversify and confidence i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3f99ce89d41c92305141b3292c4755b
https://doi.org/10.1016/j.jala.2006.08.009