Zobrazeno 1 - 10
of 315
pro vyhledávání: '"PEDRO P. CUNHA"'
Autor:
David Bargiela, Pedro P. Cunha, Pedro Veliça, Lena C. M. Krause, Madara Brice, Laura Barbieri, Milos Gojkovic, Iosifina P. Foskolou, Helene Rundqvist, Randall S. Johnson
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cells must adapt to variations in tissue microenvironments; these adaptations include the degree of oxygen availability. The hypoxia-inducible factor (HIF) transcription factors control much of this adaptation, and thus regulate many aspects of T c
Externí odkaz:
https://doaj.org/article/d703e346bf7c41fdb678fe61ec28ff79
Autor:
Iosifina P. Foskolou, Pedro P. Cunha, Elena Sánchez-López, Eleanor A. Minogue, Benoît P. Nicolet, Aurélie Guislain, Christian Jorgensen, Sarantos Kostidis, Nordin D. Zandhuis, Laura Barbieri, David Bargiela, Demitris Nathanael, Petros A. Tyrakis, Asis Palazon, Martin Giera, Monika C. Wolkers, Randall S. Johnson
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113013- (2023)
Summary: 2-Hydroxyglutarate (2HG) is a byproduct of the tricarboxylic acid (TCA) cycle and is readily detected in the tissues of healthy individuals. 2HG is found in two enantiomeric forms: S-2HG and R-2HG. Here, we investigate the differential roles
Externí odkaz:
https://doaj.org/article/8bf56a3c50134fed9555ff2704dda5a3
Autor:
Carlos Neto de Carvalho, Fernando Muñiz, Luis M. Cáceres, Zain Belaústegui, Joaquín Rodríguez-Vidal, João Belo, Noel Moreira, Mário Cachão, Pedro P. Cunha, Silvério Figueiredo, José María Galán, Yilu Zhang, Paula Gómez, Antonio Toscano, Francisco Ruiz, Samuel Ramírez-Cruzado, Francisco Giles-Guzmán, Geraldine Finlayson, Stewart Finlayson, Clive Finlayson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract In the Iberian Peninsula the fossil record of artiodactyls spans over 53 million years. During the Pleistocene, wild cattle species such as Bison and especially Bos became common. In Late Pleistocene, the aurochs (Bos primigenius) was widesp
Externí odkaz:
https://doaj.org/article/77e3bc6d6e5943e1bc9cc81f2eef27c6
Autor:
Laura Barbieri, Pedro Veliça, Paulo A. Gameiro, Pedro P. Cunha, Iosifina P. Foskolou, Eric Rullman, David Bargiela, Randall S. Johnson, Helene Rundqvist
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionCD8+ T cells infiltrate virtually every tissue to find and destroy infected or mutated cells. They often traverse varying oxygen levels and nutrient-deprived microenvironments. High glycolytic activity in local tissues can result in signi
Externí odkaz:
https://doaj.org/article/19986cb6845141b5b562fb124f546668
Autor:
David Bargiela, Pedro P. Cunha, Pedro Veliça, Iosifina P. Foskolou, Laura Barbieri, Helene Rundqvist, Randall S. Johnson
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Targeting T cell metabolism is an established method of immunomodulation. Following activation, T cells engage distinct metabolic programs leading to the uptake and processing of nutrients that determine cell proliferation and differentiation. Redire
Externí odkaz:
https://doaj.org/article/668d9ea290db4d1cbceb843d033cf4c2
Publikováno v:
Acta Palaeobotanica, Vol 59, Iss 2, Pp 215-228 (2019)
Palynofloral assemblages are an invaluable source of information about the interactions between fossil plants and their environments. Here we describe a new Early Cretaceous palynoflora from the Lusitanian Basin in the Estremadura region of central w
Externí odkaz:
https://doaj.org/article/4c5638d3f74c450caf823782f6656084
Autor:
Milos Gojkovic, Pedro P. Cunha, Gabriella S. Darmasaputra, Laura Barbieri, Helene Rundqvist, Pedro Veliça, Randall S. Johnson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Myeloid cell interactions with cells of the adaptive immune system are an essential aspect of immunity. A key aspect of that interrelationship is its modulation by the microenvironment. Oxygen is known to influence myelosuppression of T cell activati
Externí odkaz:
https://doaj.org/article/32ba1e879f97419cb6394ac9fbdd1b75
Publikováno v:
Environmental and Sustainability Indicators, Vol 6, Iss , Pp - (2020)
The mismatch between the conceptual understanding of the Ecosystem Services (ES) in science, and their practical application, remains. Among the many issues under discussion is the link between knowledge and implementation. Base knowledge built over
Externí odkaz:
https://doaj.org/article/1da598aabb2a4bb5afe1f8996093c9cc
Autor:
Pedro P. Cunha, Sara Cura, João Pedro Cunha Ribeiro, Silvério Figueiredo, António A. Martins, Luis Raposo, Telmo Pereira, Nelson Almeida
Publikováno v:
Journal of Lithic Studies, Vol 4, Iss 3 (2017)
Através dos registos geomorfológicos e sedimentares, os rios fornecem relevantes arquivos de mudanças paleoambientais, nomeadamente paleoclimáticas e paleogeográficas. As sucessões sedimentares melhor datadas são as mais importantes, com as id
Externí odkaz:
https://doaj.org/article/67bb7bf4537142678b1bcb06d30ee9b3
Publikováno v:
Cadernos de Geografia, Iss 30-31 (2012)
Este trabalho faz uma análise da suscetibilidade a deslizamentos na área da plataforma litoral entre a Figueira da Foz e a Nazaré. Pretende-se efetuar uma cartografia de suscetibilidade, pelo método de análise hierárquica de pares, que constitu
Externí odkaz:
https://doaj.org/article/6ef126c0b0d645e79aa1e6a1908b6c9d