Výsledky vyhledávání - "PE, Phycoerythrin"

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

Autor: Kenneth K.W. To, Jiang Ma, Stella Chai, Chunyuan Zhang, Chun Yin, Sheng Yao, Xu Wu, Thomas Efferth, Yang Ye, Onat Kadioglu, Ge Lin

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1885-1902 (2021)

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10ca45cdbb87dcf2ef29e5865d5f864
https://doi.org/10.1016/j.apsb.2020.12.021

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Identification of potential therapeutic target of naringenin in breast cancer stem cells inhibition by bioinformatics and in vitro studies

Autor: Riris Istighfari Jenie, Adam Hermawan, Haruma Anggraini Muflikhasari, Sonia Meta Angraini, Ika Putri Nurhayati, Muthi Ikawati, Herwandhani Putri, Annisa Khumaira

Publikováno v: Saudi Pharmaceutical Journal, Vol 29, Iss 1, Pp 12-26 (2021)
Saudi Pharmaceutical Journal : SPJ

Cancer therapy is a strategic measure in inhibiting breast cancer stem cell (BCSC) pathways. Naringenin, a citrus flavonoid, was found to increase breast cancer cells’ sensitivity to chemotherapeutic agents. Bioinformatics study and 3D tumorsphere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03402ed7467206943b40608489084242
https://doi.org/10.1016/j.jsps.2020.12.002

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The A150V Polymorphism of Genotype 3 Hepatitis C Virus Polymerase Inhibits Interferon Alfa by Suppressing Protein Kinase R Activation

Autor: Swathi Rajagopal, Graham R. Foster, Meleri Jones, Peter A C Wing, Wing-Yiu Jason Lee

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1163-1175 (2021)

Background & Aims Despite recent advances in antiviral therapy for hepatitis C virus (HCV), a proportion of patients with genotype 3 (G3) HCV infection do not respond to current all oral treatment regimens. Genomic analyses have identified key polymo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fe162bc735269108d5d64ef2756901
https://doi.org/10.1016/j.jcmgh.2020.11.012

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Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways

Autor: Hadeel, Kheraldine, Gupta, Ishita, Alhussain, Hashim, Jabeen, Aayesha, Cyprian, Farhan S., Akhtar, Saghir, Al Moustafa, Ala-Eddin, Rachid, Ousama

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2881-2890 (2021)
Computational and Structural Biotechnology Journal

Graphical abstract
HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–25% of the total cases. It is characterized by aggressive behavior and treatment resistance. On the other hand, poly (amidoamine) (PAMAM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2e2eba76f69700ffbf39aa59f09d45e6
http://www.sciencedirect.com/science/article/pii/S2001037021001926

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ANKRD22 Drives Rapid Proliferation of Lgr5+ Cells and Acts as a Promising Therapeutic Target in Gastric Mucosal Injury

Autor: Rui Wang, Dandan Zhong, Yiqing Qiu, Jingni Wu, Yongliang Zhu, Zhenya Song, Jingwen Liu, Hongping Wang

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1433-1455 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Rapid gastric epithelial progenitor cell (EPC) proliferation and inflammatory response inhibition play key roles in promoting the repair of gastric mucosal damage. However, specific targets inducing these effects are unknown. In thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f416abd6bb2732c90ffabe02f872fe52
https://doi.org/10.1016/j.jcmgh.2021.06.020

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Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet

Autor: Anthony M. Diomino, David A. Brenner, Hyeok Choon Kwon, Gibraan Rahman, Sara Brin Rosenthal, Tatiana Kisseleva, Linshan Shang, Souradipta Ganguly, Ruoyu Wang, Debanjan Dhar, Rob Knight, Pejman Soorosh, Mojgan Hosseini, Yanhan Wang, Bernd Schnabl, German R. Aleman Muench

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 891-920 (2021)
Cellular and molecular gastroenterology and hepatology, vol 12, iss 3

Background & Aims How benign liver steatosis progresses to nonalcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma (HCC) remains elusive. NASH progression entails diverse pathogenic mechanisms and relies on complex cross-talk betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b88e146fb92107eb8ff000fbb198af7
https://doi.org/10.1016/j.jcmgh.2021.05.010

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Escherichia coli–Specific CD4+ T Cells Have Public T-Cell Receptors and Low Interleukin 10 Production in Crohn’s Disease

Autor: Amiko M. Uchida, Andrew Konecny, Elisa K. Boden, Eddie A. James, James D. Lord, Donna M. Shows

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 507-526 (2020)

Background & Aims Crohn’s disease (CD) likely represents decreased immune tolerance to intestinal bacterial antigens. Most CD patients have high titers of antibodies to intestinal commensal proteins, including the outer membrane porin C (OmpC) of E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dcb1041cbd711816b296f973e738bb
http://europepmc.org/articles/PMC7385044

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Intranasal immunization with a Middle East respiratory syndrome-coronavirus antigen conjugated to the M-cell targeting ligand Co4B enhances antigen-specific mucosal and systemic immunity and protects against infection

Autor: Ye Lin Yang, Ju Kim, Yongsu Jeong, Yong-Suk Jang

Publikováno v: Vaccine

Middle East respiratory syndrome (MERS) is a threat to public health worldwide. A vaccine against the causative agent of MERS, MERS-coronavirus (MERS-CoV), is urgently needed. We previously identified a peptide ligand, Co4B, which can enhance antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc55cf0e7c952a6283a1f1f82a338e93
http://europepmc.org/articles/PMC8716170

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Physachenolide C induces complete regression of established murine melanoma tumors via apoptosis and cell cycle arrest

Autor: A. A. L. Gunatilaka, E. M. K. Wijeratne, Anne M. Macy, Ya-Ming Xu, Aparna R. Sertil, Anngela C Adams, Alexandra Charos, Karen Taraszka Hastings, Marcus Bosenberg, K. F. Castro-Ochoa, Manping X. Liu, Paul Kang

Publikováno v: Translational Oncology
Translational Oncology, Vol 15, Iss 1, Pp 101259-(2022)

Highlights • PCC and LG-134 had direct cytotoxicity in murine melanoma cell lines (IC50 values ranged from 0.19–1.8 µM). • PCC treatment induced apoptosis of tumor cells both in vitro and in vivo. • PCC treatment induced G0-G1 cell cycle arr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd404cf955dadb327000597cd983468
http://europepmc.org/articles/PMC8571524

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Bispecific antibodies with Fab-arms featuring exchanged antigen-binding constant domains

Autor: Gordana Wozniak-Knopp, Gerhard Stadlmayr, Florian Rüker, Filippo Benedetti, Katharina Stadlbauer, Florian Stracke

Publikováno v: Biochemistry and Biophysics Reports, Vol 26, Iss, Pp 100959-(2021)
Biochemistry and Biophysics Reports

Monoclonal antibodies can acquire the property of engagement of a second antigen via fusion methods or modification of their CDR loops, but also by modification of their constant domains, such as in the mAb2 format where a set of mutated amino acid r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c997320026475eb785e37d7aee392cf
http://www.sciencedirect.com/science/article/pii/S2405580821000534

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