Zobrazeno 1 - 10
of 6 746
pro vyhledávání: '"PDZ domain"'
Publikováno v:
Thrombosis Journal, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Tissue factor (TF) activity is stringently regulated through processes termed encryption. Post-translational modification of TF and its interactions with various protein and lipid moieties allows for a multi-step de-encryption of
Externí odkaz:
https://doaj.org/article/15ca8484b98a4059bd680b8ce97d9540
Autor:
Nehru Viji Sankaranarayanan, Bharath Kumar Villuri, Balaji Nagarajan, Sarah Lewicki, Swadesh K. Das, Paul B. Fisher, Umesh R. Desai
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1287 (2024)
MDA-9/Syntenin, a key scaffolding protein and a molecular hub involved in a diverse range of cell signaling responses, has proved to be a challenging target for the design and discovery of small molecule probes. In this paper, we report on the design
Externí odkaz:
https://doaj.org/article/786773569ac84ca884da51098745ec55
Akademický článek
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Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-11 (2022)
Abstract SorLA is a member of the Vps10p-domain (Vps10p-D) receptor family of type-I transmembrane proteins conveying neuronal endosomal sorting. The extracellular/luminal moiety of SorLA has a unique mosaic domain composition and interacts with a la
Externí odkaz:
https://doaj.org/article/c19f96be23164ff8b580d668e8eb726c
Publikováno v:
BioChem, Vol 2, Iss 1, Pp 83-92 (2022)
PDZ domains are involved in many cellular processes and are key regulators of the cell physiology. A huge number of studies have investigated the binding specificity of PDZ domains to the carboxyl-terminal sequence of target proteins, while the molec
Externí odkaz:
https://doaj.org/article/166ca89d3e2c46aca41eb8b112dba77f
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 40-49 (2022)
Members of the high temperature requirement A (HtrA) protein family are widely distributed amongst prokaryotic and eukaryotic species. HtrA proteins have ATP-independent dual chaperone-protease activity and mediate protein quality control. Emerging e
Externí odkaz:
https://doaj.org/article/623898a785d64a31b7b1e95cda0ca4ed
Akademický článek
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Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Bin-Amphiphysin-Rvs (BAR) domain proteins are critical regulators of membrane geometry. They induce and stabilize membrane curvature for processes, such as clathrin-coated pit formation and endosomal membrane tubulation. BAR domains form their charac
Externí odkaz:
https://doaj.org/article/75542ef1af0f49db908bad4504481330
Autor:
Muhammad Ali, Mishal Mariam McAuley, Susanne Lüchow, Stefan Knapp, Andreas C. Joerger, Ylva Ivarsson
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss , Pp 41-50 (2021)
PDZ domains constitute a large family of modular domains that are well-known for binding C-terminal motifs of target proteins. Some of them also bind to internal PDZ binding motifs (PDZbms), but this aspect of the PDZ interactome is poorly studied. H
Externí odkaz:
https://doaj.org/article/a9dcaca7d1504e669fe90b5e5dbea852
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Mitochondrial high-temperature requirement protease A2 (HtrA2) is an integral member of the HtrA family of serine proteases that are evolutionarily conserved from prokaryotes to humans. Involvement in manifold intricate cellular networks and diverse
Externí odkaz:
https://doaj.org/article/b5861a8d13df4f59b24e7b4652c2e50e