Zobrazeno 1 - 10
of 1 384
pro vyhledávání: '"PDL1"'
Autor:
Clare E. Murray, Anand V. R. Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara de la Peña Avalos, Cody M. Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S. Padron, Jacob T. Boyd, Ryan Reyes, Curtis A. Clark, Robert S. Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R. Conejo-Garcia, Lauren A. Byers, Kavya Ramkumar, Anil K. Sood, Jung-Min Lee, Christin E. Burd, Ratna K. Vadlamudi, Harshita B. Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Background Aside from the canonical role of PDL1 as a tumour surface-expressed immune checkpoint molecule, tumour-intrinsic PDL1 signals regulate non-canonical immunopathological pathways mediating treatment resistance whose significance, me
Externí odkaz:
https://doaj.org/article/324b033e9fa34bbcab45721b8054a03a
Myeloid-derived suppressor cells in axial spondyloarthritis patients with different types of therapy
Autor:
A. Yu. Morenkova, T. V. Tyrinova, A. V. Fedorova, M. A. Tikhonova, N. A. Ilina, O. A. Chumasova, A. E. Sizikov, E. R. Chernykh
Publikováno v:
Научно-практическая ревматология, Vol 62, Iss 3, Pp 300-308 (2024)
Aim – to evaluate myeloid-derived suppressor cell (MDSC) subset counts and their suppressor potential in axial spondyloarthritis (axSpA) patients, as well as to analyze changes in the studied parameters in biological therapy (BT).Materials and meth
Externí odkaz:
https://doaj.org/article/56394c5e0f444b16b7e7db9b2e87bf83
Autor:
Yuan-jie Liu, Jie-pin Li, Mei Han, Jing-xiao Li, Qian-wen Ye, Si-tian Lin, Jin-yong Zhou, Shen-lin Liu, Xi Zou
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-29 (2024)
Abstract The importance of the immune microenvironment in poorly cohesive carcinoma (PCC) has been highlighted due to its limited response rate to conventional therapy and emerging treatment resistance. A combination of clinical cohorts, bioinformati
Externí odkaz:
https://doaj.org/article/8c99cec307fb41e49ae66c8229c78ae7
Autor:
José L. Blaya-Cánovas, Carmen Griñán-Lisón, Isabel Blancas, Juan A. Marchal, César Ramírez-Tortosa, Araceli López-Tejada, Karim Benabdellah, Marina Cortijo-Gutiérrez, M. Victoria Cano-Cortés, Pablo Graván, Saúl A. Navarro-Marchal, Jaime Gómez-Morales, Violeta Delgado-Almenta, Jesús Calahorra, María Agudo-Lera, Amaia Sagarzazu, Carlos J. Rodríguez-González, Tania Gallart-Aragón, Christina Eich, Rosario M. Sánchez-Martín, Sergio Granados-Principal
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-20 (2024)
Abstract Background Active targeting by surface-modified nanoplatforms enables a more precise and elevated accumulation of nanoparticles within the tumor, thereby enhancing drug delivery and efficacy for a successful cancer treatment. However, surfac
Externí odkaz:
https://doaj.org/article/7eccea89fef54fdfadb06b2ab6ab804f
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background The impact of immune checkpoint inhibitors (ICIs) based treatments on non-small cell lung cancers (NSCLCs) with RET fusions remains poorly understood. Methods We screened patients with RET fusions at the First Affiliated Hospital
Externí odkaz:
https://doaj.org/article/8ea25916d815463c8b5343bf26a27f79
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Case reportA 55-year-old male patient developed a mass in the left inguinal area with left lower limb swelling and first visited a local hospital 3 months earlier because of unrelieved pain. An MRI scan suggested left suprapubic branch and left aceta
Externí odkaz:
https://doaj.org/article/b18139dc9933423492cfcf2a50b7b5d3
Autor:
Jeremy Richard, Céline Beauvillain, Maxime Benoit, Magalie Barth, Cécile Aubert, Cyrielle Rolley, Sarah Bellal, Jennifer Bourreau, Matthieu Ferragu, Souhil Lebdai, Arnaud Chevrollier, Daniel Henrion, Vincent Procaccio, Pierre Bigot
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionClear cell renal cell carcinoma (ccRCC) is characterized by a predominant metabolic reprogramming triggering energy production by anaerobic glycolysis at the expense of oxydative phosphorylation. Ketogenic diet (KD), which consists of hig
Externí odkaz:
https://doaj.org/article/27f23105d4a04a099e22de953be7e32c
Autor:
Aida Jlassi, Rim Rejaibi, Maroua Manai, Ghada Sahraoui, Fatma Zahra Guerfali, Lamia Charfi, Amel Mezlini, Mohamed Manai, Karima Mrad, Raoudha Doghri
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionImmunotherapy by blocking immune checkpoints programmed death/ligand (PD1/PDL1) and cytotoxic T-lymphocyte-associated protein 4(CTLA4) has emerged as new therapeutic targets in cancer. However, their efficacy has been limited due to resis
Externí odkaz:
https://doaj.org/article/cb33d3647301400aae5d4036db415272
Autor:
Kalliopi Domvri, Alexey V. Yaremenko, Apostolos Apostolopoulos, Savvas Petanidis, Sofia Karachrysafi, Nikoleta Pastelli, Theodora Papamitsou, Styliani Papaemmanouil, Sofia Lampaki, Konstantinos Porpodis
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e27208- (2024)
Lung cancer is a leading cause of cancer-related deaths globally, includes small cell lung cancer (SCLC), characterized by its aggressive nature and advanced disease at diagnosis. However, the identification of reliable biomarkers for SCLC has proven
Externí odkaz:
https://doaj.org/article/f9d8f32ee6e946239b98fbc6f2a726f2
Autor:
Andrea Sacconi, Paola Muti, Claudio Pulito, Giulia Urbani, Matteo Allegretti, Raul Pellini, Nikolay Mehterov, Uri Ben-David, Sabrina Strano, Paolo Bossi, Giovanni Blandino
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-11 (2023)
Abstract Background Immune checkpoint inhibitors (ICIs) are a therapeutic strategy for various cancers although only a subset of patients respond to the therapy. Identifying patients more prone to respond to ICIs may increase the therapeutic benefit
Externí odkaz:
https://doaj.org/article/d78903983c76433080b685a34a6e160d