Zobrazeno 1 - 10
of 4 431
pro vyhledávání: '"PDGFRa"'
Autor:
Nathaniel Grabill, MD, Mena Louis, DO, Mariah Cawthon, MD, Joseph Conway, MD, James Chambers, MD
Publikováno v:
Radiology Case Reports, Vol 19, Iss 11, Pp 4824-4831 (2024)
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, frequently characterized by mutations in the KIT or PDGFRA genes. This case report details the complex clinical course of a 71-year-old f
Externí odkaz:
https://doaj.org/article/4a0c6945dac640c99e1d1f48987ac52d
Autor:
Junya Yamaguchi, Fumiharu Ohka, Masafumi Seki, Kazuya Motomura, Shoichi Deguchi, Yoshiki Shiba, Yuka Okumura, Yuji Kibe, Hiroki Shimizu, Sachi Maeda, Yuhei Takido, Ryo Yamamoto, Akihiro Nakamura, Kennosuke Karube, Ryuta Saito
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-7 (2024)
Abstract Mutations in the isocitrate dehydrogenase (IDH) gene are recognized as the key drivers in the oncogenesis of astrocytoma and oligodendroglioma. However, the significance of IDH mutation in tumor maintenance and malignant transformation has n
Externí odkaz:
https://doaj.org/article/f9f5ded7c6c5412cb0f008ce4aa78f77
Autor:
Ana Lilia Torres-Machorro, Carina Becerril, Everardo Hernández-Plata, Erika Rubí Luis-García, Mariel Maldonado, Iliana Herrera, Miguel Negreros, Fernando Hernández-Sánchez, Criselda Mendoza-Milla, Miguel Gaxiola, Remedios Ramírez, Annie Pardo, Ivette Buendía-Roldán, Moisés Selman, José Cisneros
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Hypersensitivity pneumonitis (HP) is an immune-mediated inflammatory interstitial lung disease that may evolve to pulmonary fibrosis, a progressive disorder with a poor prognosis characterized by fibroblast activation and extracellular matri
Externí odkaz:
https://doaj.org/article/7289dbc72dcb4c04af56d49223beee3f
Autor:
Valentine Goffette, Nathalie Sabin, Jerôme Bugeon, Sabrina Jagot, Isabelle Hue, Jean-Charles Gabillard
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Interactions between tissues and cell types, mediated by cytokines or direct cell–cell exchanges, regulate growth. To determine whether mature adipocytes influence the in vitro growth of trout mononucleated muscle cells, we developed an in
Externí odkaz:
https://doaj.org/article/1ae50c06f8f34583bd07aaf9c1e67b76
Publikováno v:
eLife, Vol 13 (2024)
Signaling through the platelet-derived growth factor receptor alpha (PDGFRα) plays a critical role in craniofacial development. Phosphatidylinositol 3-kinase (PI3K)/Akt is the primary effector of PDGFRα signaling during mouse skeletal development.
Externí odkaz:
https://doaj.org/article/78ffe3761bce4bd8bfebf99d5fddbf85
Autor:
Tao Zhou, Huayun Yan, Yiqi Deng, Yunfeng Zhu, Xuyang Xia, Wanchun Wu, Wei‐Han Zhang, Hai‐Ning Chen, Jian‐Kun Hu, Zong‐Guang Zhou, Yang Shu, Yuan Li, Heng Xu
Publikováno v:
Interdisciplinary Medicine, Vol 2, Iss 4, Pp n/a-n/a (2024)
Abstract Long non‐coding RNAs (lncRNAs) can crucially regulate activation and transformation of cancer‐associated fibroblasts (CAFs) but have not been systematically investigated at single cell resolution. Here, by utilizing integrated single‐c
Externí odkaz:
https://doaj.org/article/4759bc0b0d53405685bf084193915cdc
Autor:
Yuji Kibe, Fumiharu Ohka, Kosuke Aoki, Junya Yamaguchi, Kazuya Motomura, Eiji Ito, Kazuhito Takeuchi, Yuichi Nagata, Satoshi Ito, Nobuhiko Mizutani, Yoshiki Shiba, Sachi Maeda, Tomohide Nishikawa, Hiroki Shimizu, Ryuta Saito
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Li-Fraumeni syndrome (LFS) is an autosomal dominant tumor predisposition syndrome caused by heterozygous germline mutations or deletions in the TP53 tumor suppressor gene. Central nervous system tumors, such as choroid plexus tumors, medullo
Externí odkaz:
https://doaj.org/article/8a4831412d03486798dd6a0ea60ec8dd
Autor:
Sultan Almuntashiri, Saugata Dutta, Yin Zhu, Siddhika Gamare, Gustavo Ramírez, Valeria Irineo‐Moreno, Angel Camarena, Nora Regino, Paloma Campero, Carmen M. Hernández‐Cardenas, Tatiana S. Rodriguez‐ Reyna, Joaquin Zuñiga, Caroline A. Owen, Xiaoyun Wang, Duo Zhang
Publikováno v:
Physiological Reports, Vol 12, Iss 17, Pp n/a-n/a (2024)
Abstract Increased circulating tissue inhibitor of metalloproteinases‐1 (TIMP‐1) levels have been observed in patients with acute lung injury (ALI). However, the sex‐specific regulation of TIMP‐1 and the underlying molecular mechanisms have n
Externí odkaz:
https://doaj.org/article/7223b546f3e24913873b0f47f27eafd7
Publikováno v:
European Journal of Translational Myology (2024)
Papillary thyroid carcinoma is an epithelial malignancy with follicular cell differentiation and sets of defined nuclear features and appearance of an irregular solid mass. The main objective of our study is to research on the expression of miR-218-2
Externí odkaz:
https://doaj.org/article/ce0c2d022b604fb388c1961deb931ebd
Publikováno v:
Успехи молекулярной онкологии, Vol 10, Iss 4, Pp 61-75 (2023)
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Their main features are the expression of CD117 (KIT) and mutations of KIT or PDGFRA in 85 % of patients. however, 10–15 % of adult GIST an
Externí odkaz:
https://doaj.org/article/53514d2319554e13888834c8cc7ca1ab