Zobrazeno 1 - 10
of 213
pro vyhledávání: '"PDE6B"'
Autor:
Mingzhu Yang, Ruiqi Qiu, Xiuxiu Jin, Shun Yao, Weiping Wang, Jingyang Liu, Guangming Liu, Jinfeng Han, Bo Lei
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Retinitis pigmentosa (RP) is a progressive and degenerative retinal disease resulting in severe vision loss. RP have been extensively studied for pathogenetic mechanisms and treatments. Yet there is little information about alterations of RP
Externí odkaz:
https://doaj.org/article/ae8d4d8f3264411c850837add40663ff
Autor:
Geetika Nehra, Sasivimon Promsan, Ruedeemars Yubolphan, Wijitra Chumboatong, Pornpun Vivithanaporn, Bryan J. Maloney, Anusorn Lungkaphin, Bjoern Bauer, Anika M. S. Hartz
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract Background Patients with Alzheimer's disease (AD) develop blood–brain barrier dysfunction to varying degrees. How aging impacts Aβ pathology, blood–brain barrier function, and cognitive decline in AD remains largely unknown. In this stu
Externí odkaz:
https://doaj.org/article/b356e3c9c2a2479891a940c110867957
Autor:
Nobia Aziz, Mukhtar Ullah, Abdur Rashid, Zubair Hussain, Khadim Shah, Azeem Awan, Muhammad Khan, Inam Ullah, Atta Ur Rehman
Publikováno v:
BMC Ophthalmology, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Background Retinitis pigmentosa (RP) is one of the most frequent hereditary retinal diseases that often starts with night blindness and eventually leads to legal blindness. Our study aimed to identify the underlying genetic cause of autosoma
Externí odkaz:
https://doaj.org/article/41977b789d00439aa61bc62bf1401d23
Autor:
Jing Su, Kaiqin She, Li Song, Xiu Jin, Ruiting Li, Qinyu Zhao, Jianlu Xiao, Danian Chen, Hui Cheng, Fang Lu, Yuquan Wei, Yang Yang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 596-609 (2023)
Retinitis pigmentosa (RP) is a group of retinal diseases that cause the progressive death of retinal photoreceptor cells and eventually blindness. Mutations in the β-domain of the phosphodiesterase 6 (Pde6b) gene are the most identified causes of au
Externí odkaz:
https://doaj.org/article/5ec30796bfbe45b8936cdf509809cbdf
Autor:
Angelina V. Chirinskaite, Alexander Yu. Rotov, Mariia E. Ermolaeva, Lyubov A. Tkachenko, Anastasia N. Vaganova, Lavrentii G. Danilov, Ksenia N. Fedoseeva, Nicolay A. Kostin, Julia V. Sopova, Michael L. Firsov, Elena I. Leonova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17180 (2023)
Many retinal degenerative diseases result in vision impairment or permanent blindness due to photoreceptor loss or dysfunction. It has been observed that Pde6brd1 mice (rd1), which carry a spontaneous nonsense mutation in the pde6b gene, have a stron
Externí odkaz:
https://doaj.org/article/54aac568102f4810b41b906f5109c84d
Akademický článek
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Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3173 (2023)
The cGMP-phosphodiesterase 6 beta subunit (PDE6B) is an essential component in the phototransduction pathway for light responses in photoreceptor cells. PDE6B gene mutations cause the death of rod photoreceptors, named as hereditary retinitis pigment
Externí odkaz:
https://doaj.org/article/497ac1dd183149bf9311ebaf0ce7a341
Akademický článek
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Autor:
Jee Myung Yang, Bora Kim, Jiehoon Kwak, Min Kyung Lee, Jeong Hoon Kim, In-Jeoung Baek, Young Hoon Sung, Joo Yong Lee
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Although rats with melanin-pigmentated retinal pigment epithelial (RPE) cells are physiologically more appropriate models for human eye research than their albino counterparts, reliable models from the former strain are not available to study retinal
Externí odkaz:
https://doaj.org/article/8048490e05764f16a819743ae56b0cf8
Autor:
Wei-Ming Yan, Pan Long, Mei-Zhu Chen, Dong-Yu Wei, Jian-Cong Wang, Zuo-Ming Zhang, Lei Zhang, Tao Chen
Publikováno v:
International Journal of Ophthalmology, Vol 14, Iss 7, Pp 990-997 (2021)
AIM: To explore whether the retinal neovascularization (NV) in a genetic mutant mice model could be ameliorated in an inherited retinitis pigmentosa (RP) mouse, which would help to elucidate the possible mechanism and prevention of retinal NV disease
Externí odkaz:
https://doaj.org/article/888ecb28e66e452688c69f2dcd908288