Zobrazeno 1 - 10
of 188
pro vyhledávání: '"PDE INHIBITOR"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD) without an identifiable cause. If not treated after diagnosis, the average life expectancy is 3–5 years. Currently approved drugs for the treatment of IPF
Externí odkaz:
https://doaj.org/article/6121352515c143939522be04961a5004
Publikováno v:
Molecules, Vol 27, Iss 23, p 8448 (2022)
Neurodegenerative diseases constitute a broad range of central nervous system disorders, characterized by neuronal degeneration. Alzheimer’s disease, Parkinson’s disease, amyolotrophic lateral sclerosis (ALS), and progressive forms of multiple sc
Externí odkaz:
https://doaj.org/article/7c0774892d8c4275be9e5415d45996f3
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/4aba11b46c0046c19b923c8d65f0650e
Autor:
Farzane Kuresh Kashgari, Aina Ravna, Georg Sager, Roy Lyså, Istvan Enyedy, Erik Sveberg Dietrichs
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 126, Iss , Pp 110109- (2020)
Background: Clinical studies have reported overexpression of PDE5 and elevation of intracellular cyclic GMP in various types of cancer cells. ABCC5 transports cGMP out of the cells with high affinity. PDE5 inhibitors prevent both cellular metabolism
Externí odkaz:
https://doaj.org/article/1c953d86b6be41e6acb239ae9df5a692
Publikováno v:
Molecules, Vol 27, Iss 4, p 1360 (2022)
Fenchone is a bicyclic monoterpene found in a variety of aromatic plants, including Foeniculum vulgare and Peumus boldus, and is used in the management of airways disorders. This study aimed to explore the bronchodilator effect of fenchone using guin
Externí odkaz:
https://doaj.org/article/cdd73caf322c4e7abec5a72e568d48ad
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 20, Iss 6, Pp 639-647 (2017)
Objective(s): Recently, we showed that some new synthetic compounds structurally related to cilostamide (4-(1,2-dihydro-2-oxoquinolin-6-hydroxy)- N-cyclohexyl-N-methylbutanamide), a selective phosphodiesterase 3 (PDE3) inhibitor, produce inotropic ef
Externí odkaz:
https://doaj.org/article/f8bf179e342d4459a24a60dbe0a94a7c
Publikováno v:
Molecules, Vol 25, Iss 4, p 1008 (2020)
The aim of the present study was to evaluate the possible gut inhibitory role of the phosphodiesterase (PDE) inhibitor roflumilast. Increasing doses of roflumilast were tested against castor oil-induced diarrhea in mice, whereas the pharmacodynamics
Externí odkaz:
https://doaj.org/article/3ea14bef2ad042eba721a15aa3011715
Akademický článek
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Akademický článek
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Publikováno v:
Expert Opin Drug Discov
INTRODUCTION---: Cyclic nucleotides, cAMP and cGMP, are important second messengers of intracellular signaling and play crucial roles in cardiovascular biology and diseases. Cyclic nucleotide phosphodiesterases (PDEs) control the duration, magnitude,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644df80974756e6184bbd6e99e702382
https://doi.org/10.1080/17460441.2020.1821643
https://doi.org/10.1080/17460441.2020.1821643