Zobrazeno 1 - 10
of 13
pro vyhledávání: '"PDC, pyruvate dehydrogenase complex"'
Autor:
Hsin Ming Chen, Jeng Fan Lo, Ching Wen Chang, Yi Fen Chen, Tz Yu Kuo, Chung Ji Liu, Hao Yuan Chia, Chia Yi Chou, Pei Chun Huang, Tsai Ying Chen, Wan Chun Li, Lu Te Chuang, Yi Ta Hsieh, Jian Min Huang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 7, Pp 641-652 (2019)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Even with increasing evidence for roles of glycolytic enzymes in controlling cancerous characteristics, the best target of candidate metabolic enzymes for lessening malignancy remains under debate. Pyruvate is a main glycolytic metabolite that could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92754b6cd8bfc62335acf4065f363f43
https://doi.org/10.1016/j.neo.2019.04.007
https://doi.org/10.1016/j.neo.2019.04.007
Autor:
Krishna K. Varadhan, Dileep N. Lobo, Paul L. Greenhaff, Dumitru Constantin-Teodosiu, Despina Constantin, Ryan P. Atkins
Publikováno v:
Clinical Nutrition (Edinburgh, Scotland)
© 2020 The Author(s) Background & aims: This post hoc study aimed to determine whether major elective abdominal surgery had any acute impact on mitochondrial pyruvate dehydrogenase complex (PDC) activity and maximal mitochondrial ATP production rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60f297c96e45ed8ad162f41f06b8100
Autor:
Jiaqi Shen, Charlie D. Chen, Yu Wei, Changyang Zhou, Siqi Liu, Yuxing Zhang, Wenhui Guo, Lu Yu, Wenqin Ying, Hui Yang, Kailun Fang, Jin Zi, Ruoxi Wu, Qidan Li
Publikováno v:
Molecular & Cellular Proteomics : MCP
The molecular mechanism associated with mammalian meiosis has yet to be fully explored, and one of the main reasons for this lack of exploration is that some meiosis-essential genes are still unknown. The profiling of gene expression during spermatog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e92ce7e8886603b79a4ddce929dda2
https://pubmed.ncbi.nlm.nih.gov/33257503
https://pubmed.ncbi.nlm.nih.gov/33257503
Autor:
Dileep N. Lobo, Despina Constantin, Dumitru Constantin-Teodosiu, Paul L. Greenhaff, Kristina K. Varadhan
Publikováno v:
Clinical Nutrition (Edinburgh, Scotland)
Summary Background & aims Postoperative hyperglycaemia is common in patients having major surgery and is associated with adverse outcomes. This study aimed to determine whether bacteraemia contributed to postoperative systemic inflammation, and wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45af6490ed64e6453fc8635e60761a6
https://doi.org/10.1016/j.clnu.2017.10.020
https://doi.org/10.1016/j.clnu.2017.10.020
Autor:
Tarek M. Abdelghany, Ibrahim Ibrahim, Matthew C. Wright, Alex Charlton, Clair Roper, Colin H Wilson, Jeremy M. Palmer, Dan Vidler, Alistair C. Leitch, David Jones, Peter G. Blain
Publikováno v:
Toxicology
Highlights • M8OI was recently found to be contaminating the environment. • M8OI was detected in the sera from 5/20 PBC patients and 1/10 controls. • M8OI is taken up by human liver hepatocytes. • M8OI is sequentially metabolised by CYPs foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359ee873e824009f4818f61e4545f7a3
https://doi.org/10.1016/j.tox.2021.152854
https://doi.org/10.1016/j.tox.2021.152854
Akademický článek
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Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 7, Iss C, Pp 78-86 (2016)
Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports
Pyruvate dehydrogenase complex (PDC) deficiency is a major inborn error of oxidative metabolism of pyruvate in the mitochondria causing congenital lactic acidosis and primarily structural and functional abnormalities of the central nervous system. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1c042a7f60f951b4bf418b31aa74b5
https://doi.org/10.1016/j.ymgmr.2016.03.012
https://doi.org/10.1016/j.ymgmr.2016.03.012
Autor:
Dimitrios P. Bogdanos, Eirini I. Rigopoulou, Shideh Pouria, Daniel S. Smyk, Miri Blank, Yehuda Shoenfeld, Pietro Invernizzi
Publikováno v:
Autoimmunity Reviews
The “exposome” is a term recently used to describe all environmental factors, both exogenous and endogenous, which we are exposed to in a lifetime. It represents an important tool in the study of autoimmunity, complementing classical immunologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b99100ad482001be9d7926e2cb47730
https://doi.org/10.1016/j.autrev.2012.12.005
https://doi.org/10.1016/j.autrev.2012.12.005
Autor:
Sharon M. Kelly, Swetha Vijayakrishnan, Robert J.C. Gilbert, J G Lindsay, P. Callow, Olwyn Byron, David Bhella, T. Forsyth
Publikováno v:
Journal of Molecular Biology
Mammalian pyruvate dehydrogenase complex (PDC) is a key multi-enzyme assembly that is responsible for glucose homeostasis maintenance and conversion of pyruvate into acetyl-CoA. It comprises a central pentagonal dodecahedral core consisting of two su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b76280dd8cb4a29d7400479054e112b
https://doi.org/10.1016/j.jmb.2010.03.043
https://doi.org/10.1016/j.jmb.2010.03.043
Publikováno v:
FEBS Open Bio
Highlights ► An early-life dietary intervention increasing the risk of obesity enhances adipocyte Pdk4 expression. ► Adenosine increases adipocyte PDK4 expression. ► An early-life dietary intervention augments PPARγ expression and enhances lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac4b479704ade634aa49f94e38b3aa5
https://pubmed.ncbi.nlm.nih.gov/23650578
https://pubmed.ncbi.nlm.nih.gov/23650578