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Targeted PARP Inhibition Combined with FGFR1 Blockade is Synthetically Lethal to Malignant Cells in Patients with Pancreatic Cancer

Autor: Shiue-Wei Lai, Oluwaseun Adebayo Bamodu, Jia-Hong Chen, Alexander TH Wu, Wei-Hwa Lee, Tsu-Yi Chao, Chi-Tai Yeh

Publikováno v: Cells, Vol 9, Iss 4, p 911 (2020)

The role and therapeutic promise of poly-ADP ribose polymerase (PARP) inhibitors in anticancer chemotherapy are increasingly being explored, particularly in adjuvant or maintenance therapy, considering their low efficacy as monotherapy agents and the

Externí odkaz: https://doaj.org/article/eef2f579eb7347209010b6dc1faee2d1

Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response

Autor: Jennifer M. Rojas, Miles E. Matsen, Thomas O. Mundinger, Gregory J. Morton, Darko Stefanovski, Richard N. Bergman, Karl J. Kaiyala, Gerald J. Taborsky Jr., Michael W. Schwartz

Publikováno v: Molecular Metabolism, Vol 4, Iss 8, Pp 561-568 (2015)

Objective: Central administration of ligands for fibroblast growth factor receptors (FGFRs) such as fibroblast growth factor-19 (FGF19) and FGF21 exert glucose-lowering effects in rodent models of obesity and type 2 diabetes (T2D). Conversely, intrac

Externí odkaz: https://doaj.org/article/74f0c344eb9a4833b43c5ebf5ed857d8

The role of interaction between fibroblast growth factor receptor and neural cell adshesion molecule in renal fibrosis

Autor: Životić, Maja

Publikováno v: Универзитет у Београду

Progression of chronic kidney disease (CKD) remains an unsolved problem in clinical nephrology since approaches to reverse or repair chronic renal injury are not yet available. Independent of the underlying disease, loss of functional kidney parenchy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=nardusnacion::a9dac9becafb5adf572e61ab821d5b3b
https://hdl.handle.net/21.15107/rcub_nardus_17423

Fibroblast Growth Factor (FGF) 23 Regulates the Plasma Levels of Parathyroid Hormone In Vivo Through the FGF Receptor in Normocalcemia, But Not in Hypocalcemia

Autor: Klaus Olgaard, Maria L. Mace, Eva Gravesen, Ewa Lewin, Anders Nordholm

Publikováno v: Mace, M L, Gravesen, E, Nordholm, A, Ølgaard, K & Lewin, E 2018, ' Fibroblast Growth Factor (FGF) 23 Regulates the Plasma Levels of Parathyroid Hormone In Vivo Through the FGF Receptor in Normocalcemia, But Not in Hypocalcemia ', Calcified Tissue International, vol. 102, no. 1, pp. 85-92 . https://doi.org/10.1007/s00223-017-0333-9
Calcified Tissue International

The calcium and phosphate homeostasis is regulated by a complex interplay between parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and calcitriol. Experimental studies have demonstrated an inhibitory effect of FG23 on PTH production an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d5728e72a5521551aeb214e71abd36
https://doi.org/10.1007/s00223-017-0333-9