Zobrazeno 1 - 10
of 48
pro vyhledávání: '"PD1 (programmed cell death protein 1)"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/a873a885bf0f4db09385e9b8e26b124f
Autor:
Victor Joo, Constantinos Petrovas, Laurence de Leval, Alessandra Noto, Michel Obeid, Craig Fenwick, Giuseppe Pantaleo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Therapeutic monoclonal antibodies (mAb) targeting the immune checkpoint inhibitor programmed cell death protein 1 (PD-1) have achieved considerable clinical success in anti-cancer therapy through relieving T cell exhaustion. Blockade of PD-1 interact
Externí odkaz:
https://doaj.org/article/065a7f9cf7cc45818a04a4f87b1fc2c0
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Up to 30% of colorectal, endometrial and gastric cancers have a deficiency in mismatch repair (MMR) protein expression due to either germline or epigenetic inactivation. Patients with Lynch Syndrome who inherit an inactive MMR allele have an up to 80
Externí odkaz:
https://doaj.org/article/f2de4f4bc43e46d4801c6329f7663996
Autor:
Devayani Machiraju, Jessica C. Hassel
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
The liver is the most preferential initial site of metastasis for uveal melanoma (mUM), and this preference is associated with rapid mortality in mUM patients. Despite the significant clinical benefits of Immune checkpoint inhibitors (ICIs) in metast
Externí odkaz:
https://doaj.org/article/448fd1802dba4a3a9b6e3889fd777c85
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The latest research suggesting that necroptosis plays a vital role in immune response. However, the influence of necroptosis on tumor microenvironment (TME) remodeling and immunotherapy is still unclear. We analyzed the variations in the expression o
Externí odkaz:
https://doaj.org/article/18ce521e3bf740dcb4c87ff80006174e
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Innate-like B cells (ILBs) are a heterogeneous population B cells which participate in innate and adaptive immune responses. This diverse subset of B cells is characterized by the expression of CD5 and has been shown to secrete high levels of immunog
Externí odkaz:
https://doaj.org/article/5660827bccf64d4ea97f9b8727080b34
Autor:
Donatella Romaniello, Valerio Gelfo, Federica Pagano, Michela Sgarzi, Alessandra Morselli, Cinzia Girone, Daria Maria Filippini, Gabriele D’Uva, Mattia Lauriola
Historically, senescence has been considered a safe program in response to multiple stresses in which cells undergo irreversible growth arrest. This process is characterized by morphological and metabolic changes, heterochromatin formation, and secre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99cb13e2989c8f94ed52f3c2285c8ad
https://hdl.handle.net/11585/914520
https://hdl.handle.net/11585/914520
Autor:
Hanjie Wang, Jin Chang, Kun Ge, Jinchao Zhang, Yu Tian, Chaonan Zhang, Wang Tiange, Yingying Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1978-1992 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Tumor recurrence after surgery is the main cause of treatment failure. However, the initial stage of recurrence is not easy to detect, and it is difficult to cure in the late stage. In order to improve the life quality of postoperative patients, an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b427dfc66786d16834b8e45da6c2b16
http://www.sciencedirect.com/science/article/pii/S2211383521001076
http://www.sciencedirect.com/science/article/pii/S2211383521001076
Akademický článek
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Autor:
Qin Guo, Chen Jiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 6, Pp 979-986 (2020)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
With the development of biotherapy, biomacromolecular drugs have gained tremendous attention recently, especially in drug development field due to the sophisticated functions in vivo. Over the past few years, a motley variety of drug delivery strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fff16fc64cd33f04dc07eb995102ed3
http://www.sciencedirect.com/science/article/pii/S2211383519311037
http://www.sciencedirect.com/science/article/pii/S2211383519311037