Zobrazeno 1 - 10
of 4 457
pro vyhledávání: '"PD-1 blockade"'
Autor:
Wenchang Zhou, Mengdi Qu, Ying Yue, Ziwen Zhong, Ke Nan, Xingfeng Sun, Qichao Wu, Jie Zhang, Wankun Chen, Changhong Miao
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Programmed cell death protein 1 (PD-1) blockade is essential in treating progressive colorectal cancer (CRC). However, some patients with CRC do not respond well to immunotherapy, possibly due to the exhaustion of CD8+ T cells in
Externí odkaz:
https://doaj.org/article/08cae4454219400b8c151d78ebbc6de4
Publikováno v:
Molecular Biomedicine, Vol 5, Iss 1, Pp 1-17 (2024)
Abstract The combination of anti-angiogenic drugs and immune checkpoint inhibitors (ICIs) in the treatment of tumors is emerging as a way to improve ICIs-resistant tumor therapy. In addition, gut microbes (GMs) are involved in angiogenesis in the tum
Externí odkaz:
https://doaj.org/article/bbf81cf0381a469caa7c04489c0eb4e1
Autor:
Yuli Ruan, Yue Ma, Ming Ma, Chao Liu, Dan Su, Xin Guan, Rui Yang, Hong Wang, Tianqin Li, Yang Zhou, Jianqun Ma, Yanqiao Zhang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Neoadjuvant immunochemotherapy (NICT) plus esophagectomy has emerged as a promising treatment option for locally advanced esophageal squamous cell carcinoma (LA-ESCC). Pathologic complete response (pCR) is a key indicator associat
Externí odkaz:
https://doaj.org/article/b47d90f9d5124142873c9d103f9f27c5
Publikováno v:
Infection and Drug Resistance, Vol Volume 17, Pp 1545-1550 (2024)
LeiLei Chen, Jingshi Wang, Zhao Wang Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Zhao Wang, Capital Medical University, Beijing, People’s Republic of China,
Externí odkaz:
https://doaj.org/article/b2632ab5188d47ff9e7c1dd277ba0565
Autor:
Alexander Emmanuelli, Camilla Salvagno, Sung-Min Hwang, Deepika Awasthi, Tito A. Sandoval, Chang-Suk Chae, Jin-Gyu Cheong, Chen Tan, Takao Iwawaki, Juan R. Cubillos-Ruiz
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
High-grade serious ovarian cancer (HGSOC) is an aggressive malignancy that remains refractory to current immunotherapies. While advanced stage disease has been extensively studied, the cellular and molecular mechanisms that promote early immune escap
Externí odkaz:
https://doaj.org/article/30db59b48ae54001846a2fc3be306ce4
Autor:
Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Ebaston Thankarajan, Michael P Luciano, Syed Muhammad Usama, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Motofumi Suzuki, Miyu Kano, Peter L Choyke, Martin J Schnermann, Hisataka Kobayashi
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Regulatory T cells (Tregs) play a crucial role in mediating immunosuppression in the tumor microenvironment. Furthermore, Tregs contribute to the lack of efficacy and hyperprogressive disease upon Programmed cell death protein 1 (PD-1) blockade immun
Externí odkaz:
https://doaj.org/article/7b1199cf64ae452891e934e44bf2ed41
Autor:
Fengyun Pei, Wan He, Yinghua Duan, Qijun Yao, Yandong Zhao, Xinjuan Fan, Shuai Liu, Haiyang Chen, Fang He, Tingzhi Liu, Jiaoting Chen, Yijia Zheng, Heping Li, Xiaofang Guo, Lishuo Shi, Li Ling, Yaoxu Chen, Jiapeng He, Miao Liu, Mengli Huang, Yuezong Bai, Jianping Wang, Meijin Huang, Jun Huang
Publikováno v:
Cancer Medicine, Vol 13, Iss 12, Pp n/a-n/a (2024)
Abstract Background Patients with DNA mismatch repair‐proficient/microsatellite stable (pMMR/MSS) colorectal cancer (CRC), which accounts for 85% of all CRC cases, display a poor respond to immune checkpoint inhibitors (i.e., anti‐PD‐1 antibodi
Externí odkaz:
https://doaj.org/article/478e2f55036f4d94b5bcf65305acb66a
Inhibition of SFTSV replication in humanized mice by a subcutaneously administered anti-PD1 nanobody
Autor:
Mengmeng Ji, Jiaqian Hu, Doudou Zhang, Bilian Huang, Shijie Xu, Na Jiang, Yuxin Chen, Yujiong Wang, Xilin Wu, Zhiwei Wu
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 575-595 (2024)
Abstract Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening disease caused by a novel bunyavirus (SFTSV), mainly transmitted by ticks. With no effective therapies or vaccines available, understanding the disease’s mechanisms i
Externí odkaz:
https://doaj.org/article/8a75e77552724ea499b21691b4717959
Autor:
Yuankui Zhu, Ke Wang, Linghe Yue, Dianbao Zuo, Junfeng Sheng, Sina Lan, Zilong Zhao, Shuang Dong, Sheng Hu, Xin Chen, Mingqian Feng
Publikováno v:
Pharmacological Research, Vol 203, Iss , Pp 107186- (2024)
Chimeric antigen receptor (CAR)-modified T cell therapy has achieved remarkable efficacy in treating hematological malignancies, but it confronts many challenges in treating solid tumors, such as the immunosuppressive microenvironment of the solid tu
Externí odkaz:
https://doaj.org/article/f8665c4783e94d56bf6dd8728ad45a3b
Autor:
Zhixiong Wang, Menglin Zhu, Runyu Dong, Danping Cao, Yanna Li, Zhiqiang Chen, Juan Cai, Xueliang Zuo
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Hypoxia, a common characteristic of the tumour microenvironment, is involved in tumour progression and immune evasion. Targeting the hypoxic microenvironment has been implicated as a promising antitumour therapeutic strategy. TH-3
Externí odkaz:
https://doaj.org/article/c040308af17441519cbe11ebe65279ee