Zobrazeno 1 - 10
of 798
pro vyhledávání: '"PCSK9 inhibitor"'
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundAtherosclerotic cardiovascular disease (ASCVD), a leading cause of global fatalities, has inconsistent findings regarding the impact of muscle symptoms despite promising clinical trials involving PCSK9 inhibitors (PCSK9i) and siRNA as poten
Externí odkaz:
https://doaj.org/article/d72a24554a4145ef8bfa9504415cff91
Autor:
Burabha Pussadhamma, Chaiyasith Wongvipaporn, Atthakorn Wutthimanop, Manit Nuinoon, Sureerut Porntadavity, Nutjaree Jeenduang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Familial hypercholesterolemia (FH) is a genetic disease characterized by elevated LDL-C levels. In this study, two FH probands and 9 family members from two families from northeastern Thailand were tested for LDLR, APOB, and PCSK9 variants b
Externí odkaz:
https://doaj.org/article/44456b5a1c4d47b18b358f2e758d6009
Autor:
N Katsiki, Td Filippatos, C Vlachopoulos, D Panagiotakos, H Milionis, A Tselepis, A Garoufi, L Rallidis, D Richter, T Nomikos, G Kolovou, K Kypreos, C Chrysohoou, K Tziomalos, I Skoumas, I Koutagiar, A Attilakos, M Papagianni, C Boutari, V Kotsis, C Pitsavos, M Elisaf, K Tsioufis, E Liberopoulos
Publikováno v:
Atherosclerosis Plus, Vol 55, Iss , Pp 74-92 (2024)
Atherosclerotic cardiovascular disease (ASCVD) remains the main cause of death worldwide, and thus its prevention, early diagnosis and treatment is of paramount importance. Dyslipidemia represents a major ASCVD risk factor that should be adequately m
Externí odkaz:
https://doaj.org/article/905273aebe6f4665b45ece5f41daa7a1
Autor:
Xian-Dan Wu, Xin-Yue Ye, Xuan-Yan Liu, Yue Lin, Xian Lin, Yan-Yan Li, Bin-Hua Ye, Jing-Chao Sun
Publikováno v:
Annals of Medicine, Vol 56, Iss 1 (2024)
Background Previous meta-analyses have investigated the efficacy of lipid-lowering therapies for atherosclerotic cardiovascular disease; however, few have focused on patients with acute coronary syndrome (ACS). This meta-analysis aimed to compare the
Externí odkaz:
https://doaj.org/article/b648df41fedd4f3e80b406d279854710
Publikováno v:
Безопасность и риск фармакотерапии, Vol 11, Iss 4, Pp 442-449 (2023)
Scientific relevance. The main cause of cardiovascular pathologies is atherosclerosis, which is secondary to lipid metabolism disorders, in particular, the accumulation of low-density lipoprotein (LDL) cholesterol. Dyslipidaemia treatment with the la
Externí odkaz:
https://doaj.org/article/5522c298d06c4f16a2dd06ad2702482c
Autor:
Milan Gupta, Rajvi J. Wani, Khalid Al Faraidy, Jean Bergeron, Eduardo Contreras, Angel Alberto Garcia Peña, G. B. John Mancini, Francisco Padilla, Abel Alberto Pavia Lopez, Kiran Philip, Johnny Wu, Erin S. Mackinnon
Publikováno v:
Cardiology and Therapy, Vol 12, Iss 4, Pp 703-722 (2023)
Abstract Introduction This study characterizes patients receiving evolocumab in clinical practice and assesses treatment effectiveness, safety and persistence outcomes across five countries. Methods This retrospective and prospective observational st
Externí odkaz:
https://doaj.org/article/871e335605904a328cdc04840034dac7
Autor:
Xian Lv, Chunyue Wang, Lu Liu, Guoqing Yin, Wen Zhang, Fuad A. Abdu, Tingting Shi, Qingfeng Zhang, Wenliang Che
Publikováno v:
Lipids in Health and Disease, Vol 22, Iss 1, Pp 1-11 (2023)
Abstract Background Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder. The primary objective of this study was to identify the major pathogenic mutations in a Chinese family with FH. Methods Whole-genome sequencing (WGS) wa
Externí odkaz:
https://doaj.org/article/a1f9ef34a536437faa7e9c8753905ba3
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundMyasthenia gravis is a rare chronic autoimmune neuromuscular disorder mainly caused by autoantibodies to the nicotinic acetylcholine receptor. Cholesterol is an essential molecule that affects the distribution and proper functioning of this
Externí odkaz:
https://doaj.org/article/94c5c3bae88546e18a43df6f366e54a6
Autor:
Madeline M. Vroom, Hanxin Lu, Maggie Lewis, Brett A. Thibodeaux, Jeanne K. Brooks, Matthew S. Longo, Martina M. Ramos, Jaya Sahni, Jonathan Wiggins, Justin D. Boyd, Shixia Wang, Shuang Ding, Michael Hellerstein, Valorie Ryan, Peter Powchik, Jean-Cosme Dodart
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 2, Pp 100497- (2024)
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of disease burden in the world and is highly correlated with chronic elevations of LDL-C. LDL-C-lowering drugs, such as statins or monoclonal antibodies against proprotein conve
Externí odkaz:
https://doaj.org/article/3293558416e04bdf9098883c37ef7a6e
Autor:
Lin Zhou, Hongyu Zhang, Shuyi Wang, Hong Zhao, Yongnan Li, Juqian Han, Hongxu Zhang, Xiaoyuan Li, Zhengyi Qu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Ischemic stroke, the most prevalent and serious manifestation of cerebrovascular disease, is the main cause of neurological problems that require hospitalization, resulting in disability and death worldwide. Currently, clinical practice focuses on th
Externí odkaz:
https://doaj.org/article/ef8c0dbb0e16478b9ebe4286e7a49c60