Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in MiceSummary

Autor: Melinda A. Engevik, Robert Fultz, Susan Venable, Wenly Ruan, Yuko Mori-Akiyama, Yanling Zhao, James Versalovic, Zhongcheng Shi, Wa Du

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 717-737 (2022)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims We previously showed that histamine suppressed inflammation-associated colonic tumorigenesis through histamine type 2 receptor (H2R) signaling in mice. This study aimed to precisely elucidate the downstream effects of H2R activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f11dc371483d9087cd2d702d253c7e
http://www.sciencedirect.com/science/article/pii/S2352345X2100237X

Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell Proliferation

Autor: Beatrice Foglia, G. Villano, Ramy Younes, Emanuele Albano, Salvatore Sutti, Patrizia Pontisso, Riccardo Autelli, Ignazia Tusa, Naresh Naik Ramavath, Chiara Rosso, Elisabetta Rovida, Elisabetta Bugianesi, Erica Novo, Stefania Cannito, Maurizio Parola, Marina Maggiora, Claudia Bocca

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 459-482 (2022)

Background & Aims Hypoxia and hypoxia-inducible factors (HIFs) are involved in chronic liver disease progression. We previously showed that hepatocyte HIF-2α activation contributed significantly to nonalcoholic fatty liver disease progression in exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a59ab5cb7a1f82eda21068f7059c53
http://europepmc.org/articles/PMC8688724

Inhibition of LIM kinase reduces contraction and proliferation in bladder smooth muscle

Autor: Xuechun Li, Ruixiao Wang, Di Gu, Xiaolong Wang, Yeda Chen, Qingfeng Yu, Yang Liu, Chengjie Wu, Wenqi Wu, Xiaolu Duan, Shujue Li, Martin Hennenberg, Guohua Zeng, Bingsheng Li, Ru Huang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1914-1930 (2021)

Overactive bladder (OAB) is the most bothersome symptom in lower urinary tract symptoms (LUTS). Current pharmacologic treatment aims to inhibit detrusor contraction; however, shows unsatisfied efficacy and high discontinuation rate. LIM kinases (LIMK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4082d9cd7f27aae3d64dc1bf5dba03a7
https://doi.org/10.1016/j.apsb.2021.01.005

Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics

Autor: Tanja Dominko, Pamela J. Weathers, David Dolivo

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 322-339 (2021)
Acta Pharmaceutica Sinica. B

Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world. Despite considerable research, few therapies have proven effective and been approved clinically for treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31e277e49b3a3364e9726d531259ad4
https://doi.org/10.1016/j.apsb.2020.09.001

IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells

Autor: Marta Acchioni, Anna Lisa Remoli, Angela Battistini, Robert Clarke, Chiara Acchioni, Giulia Marsili, Roberto Orsatti, Edvige Perrotti, Marco Sgarbanti

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 459-469 (2020)
Neoplasia (New York, N.Y.)

Interferon Regulatory Factors (IRFs) are key regulators of immunity, cell survival and apoptosis. IRF transcriptional activity and subcellular localization are tightly regulated by posttranscriptional modifications including phosphorylation. The IκB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dc31ce8201d10ab9e5e10769229024
http://www.sciencedirect.com/science/article/pii/S1476558620301354