The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells.

Autor: de Zeeuw, Pauline^1,2,3 (AUTHOR), Treps, Lucas^1,2,4 (AUTHOR), García-Caballero, Melissa^1,2,5 (AUTHOR), Harjes, Ulrike^1,2 (AUTHOR), Kalucka, Joanna^1,2,6 (AUTHOR), De Legher, Carla^1,2 (AUTHOR), Brepoels, Katleen^1,2 (AUTHOR), Peeters, Kristel^1,2 (AUTHOR), Vinckier, Stefan^1,2 (AUTHOR), Souffreau, Joris^1,2 (AUTHOR), Bouché, Ann^1,2 (AUTHOR), Taverna, Federico^1,2,7 (AUTHOR), Dehairs, Jonas⁸ (AUTHOR), Talebi, Ali⁸ (AUTHOR), Ghesquière, Bart^9,10 (AUTHOR), Swinnen, Johan⁸ (AUTHOR), Schoonjans, Luc^1,2 (AUTHOR), Eelen, Guy^1,2,11 (AUTHOR) guy.eelen@droialabs.com, Dewerchin, Mieke^1,2 (AUTHOR) mieke.dewerchin@kuleuven.be, Carmeliet, Peter^1,2,12 (AUTHOR) peter.carmeliet@kuleuven.be

Publikováno v: Communications Biology. 5/23/2024, Vol. 7 Issue 1, p1-17. 17p.

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Pck2 association with the plasma membrane and efficient response of the cell integrity pathway require regulation of PI4P homeostasis by exomer

Autor: Esteban Moscoso-Romero, Sandra Moro, Alicia Duque, Francisco Yanguas, M.-Henar Valdivieso

Publikováno v: Open Biology, Vol 14, Iss 11 (2024)

Exomer is a protein complex that facilitates trafficking between the Golgi and the plasma membrane (PM). Schizosaccharomyces pombe exomer is composed of Cfr1 and Bch1, and we have found that full activation of the cell integrity pathway (CIP) in resp

Externí odkaz: https://doaj.org/article/1b21ac37b6884c00807f49a6057593e3

The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells

Autor: Pauline de Zeeuw, Lucas Treps, Melissa García-Caballero, Ulrike Harjes, Joanna Kalucka, Carla De Legher, Katleen Brepoels, Kristel Peeters, Stefan Vinckier, Joris Souffreau, Ann Bouché, Federico Taverna, Jonas Dehairs, Ali Talebi, Bart Ghesquière, Johan Swinnen, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Peter Carmeliet

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)

Abstract Endothelial cells (ECs) are highly glycolytic, but whether they generate glycolytic intermediates via gluconeogenesis (GNG) in glucose-deprived conditions remains unknown. Here, we report that glucose-deprived ECs upregulate the GNG enzyme P

Externí odkaz: https://doaj.org/article/8030d02175c3406794109c5a78ebe4dd

DNA 5mC and RNA m 6 A Collaborate to Upregulate Phosphoenolpyruvate Carboxykinase 2 for Kupffer Cell Activation.

Autor: Zhao, Yulan^1,2 (AUTHOR), Yuan, Wenbo^1,2 (AUTHOR), Feng, Yue^1,2 (AUTHOR), Zhao, Ruqian^1,2 (AUTHOR) zhaoruqian@njau.edu.cn

Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p9894. 13p.