Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease

Autor: Aidan J. McGlinchey, Olivier Govaere, Dawei Geng, Vlad Ratziu, Michael Allison, Jerome Bousier, Salvatore Petta, Claudia de Oliviera, Elisabetta Bugianesi, Jörn M. Schattenberg, Ann K. Daly, Tuulia Hyötyläinen, Quentin M. Anstee, Matej Orešič

Publikováno v: JHEP Reports

Funder: European Commission
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is a progressive liver disease with potentially severe complications including cirrhosis and hepatocellular carcinoma. Previously, we have identified circul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dccc15694575d45eb24a234f95e9680
https://pubmed.ncbi.nlm.nih.gov/35434590

Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation

Autor: Adam Alexander T. Smith, Man K.S. Lee, Michelle Cinel, Bronwyn A. Kingwell, Sudip Paul, Paul J. Nestel, Kevin Culham, Natalie A. Mellett, Kaushala S. Jayawardana, Kevin A. Gunawan, Peter J. Meikle, Jacqueline M. Weir, Graeme I. Lancaster, Andrew J. Murphy

Publikováno v: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100092-(2021)

Plasmalogens are membrane glycerophospholipids with diverse biological functions. Reduced plasmalogen levels have been observed in metabolic diseases; hence, increasing their levels might be beneficial in ameliorating these conditions. Shark liver oi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9423795a10a3a600bca50d70a6bb5c
http://europepmc.org/articles/PMC8281607

Nonalcoholic fatty liver disease stratification by liver lipidomics

Autor: Tim Daniel Rose, Veera Raghavan Thangapandi, Andrej Shevchenko, Witigo von Schoenfels, Ünal Coskun, Thomas Züllig, Oskar Knittelfelder, Stephan Buch, Mario Brosch, Josch Konstantin Pauling, Clemens Schafmayer, Kai Schuhmann, Justus Gross, Yuting Wang, Judith Andrea Heidrun Wodke, Olga Vvedenskaya, Christoph Röcken, Edda Klipp, Harald Köfeler, Jürgen Hartler, Canan Has, Jacobo Miranda Ackerman, Alessandra Palladini, Jochen Hampe

Publikováno v: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100104-(2021)

Nonalcoholic fatty liver disease (NAFLD) is a common metabolic dysfunction leading to hepatic steatosis. However, NAFLD's global impact on the liver lipidome is poorly understood. Using high-resolution shotgun mass spectrometry, we quantified the mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9510db447a8a2cef37bc05f752c8477
https://mediatum.ub.tum.de/1650029

Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.

Autor: McGlinchey AJ; School of Medical Sciences, Örebro University, Örebro, Sweden., Govaere O; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Geng D; Department of Chemistry, Örebro University, Örebro, Sweden., Ratziu V; Assistance Publique-Hôpitaux de Paris, Hôpital Beaujon, University Paris-Diderot, Paris, France., Allison M; Liver Unit, Department of Medicine, Cambridge Biomedical Research Centre, Cambridge University NHS Foundation Trust, Cambridge, UK., Bousier J; Hepato-Gastroenterology Department, Angers University Hospital, Angers, France., Petta S; Dipartimento Biomedico di Medicina Interna e Specialistica Di.Bi.M.I.S, University of Palermo, Palermo, Italy., de Oliviera C; Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil., Bugianesi E; Department of Medical Sciences, Division of Gastro-Hepatology, A.O. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Schattenberg JM; Department of Medicine, University Hospital Mainz, Mainz, Germany., Daly AK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Hyötyläinen T; Department of Chemistry, Örebro University, Örebro, Sweden., Anstee QM; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals, NHS Foundation Trust, Newcastle upon Tyne, UK., Orešič M; School of Medical Sciences, Örebro University, Örebro, Sweden.; Turku Bioscience, University of Turku and Åbo Akademi University, Turku, Finland.

Publikováno v: JHEP reports : innovation in hepatology [JHEP Rep] 2022 Mar 26; Vol. 4 (5), pp. 100477. Date of Electronic Publication: 2022 Mar 26 (Print Publication: 2022).