Výsledky vyhledávání - "PBMC, Peripheral Blood Mononuclear Cell"

Selective BH3 mimetics synergize with BET inhibition to induce mitochondrial apoptosis in rhabdomyosarcoma cells

Autor: Ufuk Erdogdu, Nadezda Dolgikh, Stephanie Laszig, Vinzenz Särchen, Michael T. Meister, Marek Wanior, Stefan Knapp, Cathinka Boedicker

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 2, Pp 109-119 (2022)
Neoplasia (New York, N.Y.)
Neoplasia

Highlights • Co-inhibition of BET proteins and anti-apoptotic BCL-2 proteins induces apoptosis in RMS. • JQ1 and BH3-mimetics synergistically induce cell death in RMS. • Cell death is caspase-dependent and displays hallmarks of intrinsic apopto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbac6aac81f4d40d574992bf92415f7
https://doi.org/10.1016/j.neo.2021.11.012

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Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic PharmacokineticsSummary

Autor: Andreas Zollner, Nicole Przysiecki, Sophie Macheiner, Vera Reinstadler, Barbara Jelusic, Simon J. Reider, Herbert Tilg, Christina Watschinger, Alexandra Pfister, Herbert Oberacher, Alexander R. Moschen, Bernhard Texler

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 383-404 (2022)
Cellular and Molecular Gastroenterology and Hepatology

Objective By interfering with multiple cytokines, human Janus kinase inhibitors (JAKis) are of growing importance in the treatment of malignant and inflammatory conditions. Although tofacitinib has demonstrated efficacy as the first-in-class JAKi in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6e0dffe3ffcc5c8d849bd534a91dfc
http://www.sciencedirect.com/science/article/pii/S2352345X21001922

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Akademický článek

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The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment

Autor: Liwu Fu, Hong Zhang

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1400-1411 (2021)
Acta Pharmaceutica Sinica. B

A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and tumorigenesis/growth/metastasis has been widely reported. Either low or high ALDH2 express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd88ae6dedbdf2435fcfad1324d1900
https://doi.org/10.1016/j.apsb.2021.02.008

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Norovirus-Specific CD8+ T Cell Responses in Human Blood and Tissues

Autor: Ralph S. Baric, Michael R. Betts, Olesya Palko, Chi Wai Lau, Ajinkya Pattekar, Ali Naji, Lisa C. Lindesmith, Lena S. Mayer, Paul D. Brewer-Jensen, Chengyang Liu, Meenakshi Bewtra, E. John Wherry, Vesselin T. Tomov

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1267-1289 (2021)

Background & Aims Noroviruses (NoVs) are the leading cause of acute gastroenteritis worldwide and are associated with significant morbidity and mortality. Moreover, an asymptomatic carrier state can persist following acute infection, promoting NoV sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e0b504252133cddc455e553314399c
https://doi.org/10.1016/j.jcmgh.2020.12.012

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Discovery of tumor immune infiltration-related snoRNAs for predicting tumor immune microenvironment status and prognosis in lung adenocarcinoma

Autor: Qiong Chen, Bingrong Zhao, Lu Bai, Juan Jiang, Wang Ya, Yuanyuan Li, Chengping Hu, Changjing Cai, Rongjun Wan

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 6386-6399 (2021)
Computational and Structural Biotechnology Journal

Graphical abstract
Lung adenocarcinoma (LUAD) has a high mortality rate and is difficult to diagnose and treat in its early stage. Previous studies have demonstrated that small nucleolar RNAs (snoRNAs) play a critical role in tumor immune infilt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2d4043c8554ee6af7977744fd1f51b
http://www.sciencedirect.com/science/article/pii/S2001037021004979

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Deimmunization of protein therapeutics – Recent advances in experimental and computational epitope prediction and deletion

Autor: Martin J. Loessner, Mathias Schmelcher, Noël Stierlin, Léa V. Zinsli

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 315-329 (2021)
Computational and Structural Biotechnology Journal, 19

Biotherapeutics, and antimicrobial proteins in particular, are of increasing interest for human medicine. An important challenge in the development of such therapeutics is their potential immunogenicity, which can induce production of anti-drug-antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc6eb34d6710e1da9ae4b3df006a799
https://doi.org/10.1016/j.csbj.2020.12.024

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