Large deletions at the t(9;22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukemia

Autor: PB Sinclair, Anthony R. Green, Alistair Reid, M Leversha, EP Nacheva, Brian J. P. Huntly, Kim Champion, J. Chang, Nick Telford, A Bench

Publikováno v: Blood. 95:738-743

The hallmark of chronic myeloid leukemia (CML) is the BCR-ABL fusion gene, which is usually formed as a result of the t(9;22) translocation. Patients with CML show considerable heterogeneity both in their presenting clinical features and in the time

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfd2b2e962c9dcc6560d3840b1b8e4f1
https://doi.org/10.1182/blood.v95.3.738.003k21_738_743

Disruption to the FOXO-PRDM1 axis resulting from deletions of chromosome 6 in acute lymphoblastic leukaemia.

Autor: Sinclair PB; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK. Paul.Sinclair@newcastle.ac.uk., Cranston RE; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK., Raninga P; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK., Cheng J; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK., Hanna R; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK., Hawking Z; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK., Hair S; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK., Ryan SL; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK., Enshaei A; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK., Nakjang S; Bioinformatics Support Unit, Faculty of Medical Science, Newcastle University, Newcastle-Upon-Tyne, UK., Rand V; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK.; School of Health and Life Sciences, Teesside University, Middlesborough, UK.; National Horizons Centre, Teesside University, Darlington, UK., Blair HJ; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK., Moorman AV; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK., Heidenreich O; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK.; Princess Maxima Centre for Paediatric Oncology, Utrecht, The Netherlands., Harrison CJ; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-Upon-Tyne, UK. christine.harrison@newcastle.ac.uk.

Publikováno v: Leukemia [Leukemia] 2023 Mar; Vol. 37 (3), pp. 636-649. Date of Electronic Publication: 2023 Jan 20.

Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21.

Autor: Sinclair PB; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Blair HH; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Ryan SL; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Buechler L; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Cheng J; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Clayton J; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Hanna R; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Hollern S; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Hawking Z; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Bashton M; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Schwab CJ; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Jones L; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Russell LJ; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Marr H; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Carey P; Department of Clinical Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK., Halsey C; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, UK., Heidenreich O; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Moorman AV; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK., Harrison CJ; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK christine.harrison@newcastle.ac.uk.

Publikováno v: Haematologica [Haematologica] 2018 Apr; Vol. 103 (4), pp. 634-644. Date of Electronic Publication: 2018 Feb 15.

Insights into interphase large-scale chromatin structure from analysis of engineered chromosome regions.

Autor: Belmont AS; Department of Cell and Developmental Biology and Center for Biophysics and Computational Biology, University of Illinois, Urbana, Illinois 61801, USA. asbel@illinois.edu, Hu Y, Sinclair PB, Wu W, Bian Q, Kireev I

Publikováno v: Cold Spring Harbor symposia on quantitative biology [Cold Spring Harb Symp Quant Biol] 2010; Vol. 75, pp. 453-60. Date of Electronic Publication: 2011 Apr 05.

A fluorescence in situ hybridization map of 6q deletions in acute lymphocytic leukemia: identification and analysis of a candidate tumor suppressor gene.

Autor: Sinclair PB; Haematology Department, Royal Free and University College School of Medicine, London, United Kingdom., Sorour A, Martineau M, Harrison CJ, Mitchell WA, O'Neill E, Foroni L

Publikováno v: Cancer research [Cancer Res] 2004 Jun 15; Vol. 64 (12), pp. 4089-98.