Caracterización parcial del proteoma del trofozoíto de Plasmodium falciparum bajo tratamiento con quinina, mefloquina y el compuesto natural diosgenona

Autor: César Segura, Yesid Cuesta-Astroz, Camila Nunes-Batista, Mariano Zalis, Wanda Maria De Almeida von Krüger, Paulo Mascarello Bisch

Publikováno v: Biomédica: revista del Instituto Nacional de Salud, Vol 34, Iss 2, Pp 237-49 (2014)

Introducción. A pesar de los esfuerzos para controlar la malaria, esta sigue siendo un problema de salud pública. Plasmodium falciparum es responsable de la mayoría de los casos graves y de las muertes. Los programas de control de la malaria han s

Externí odkaz: https://doaj.org/article/8e90990ab4a240348ea306b2567617b6

Structural changes of the paraflagellar rod during flagellar beating in Trypanosoma cruzi.

Autor: Gustavo Miranda Rocha, Dirceu Esdras Teixeira, Kildare Miranda, Gilberto Weissmüller, Paulo Mascarello Bisch, Wanderley de Souza

Publikováno v: PLoS ONE, Vol 5, Iss 6, p e11407 (2010)

BACKGROUND: Trypanosoma cruzi, the agent of Chagas disease, is a protozoan member of the Kinetoplastidae family characterized for the presence of specific and unique structures that are involved in different cell activities. One of them is the parafl

Externí odkaz: https://doaj.org/article/abe1fe4fbb504402a1b8736977182263

The C‐terminal extension of VgrG4 from Klebsiella pneumoniae remodels host cell microfilaments

Autor: Talyta do Nascimento Soares, Verônica Silva Valadares, Gisele Cardoso Amorim, Mayara de Mattos Lacerda de Carvalho, Marcia Berrêdo‐Pinho, Fábio Ceneviva Lacerda Almeida, Paulo Mascarello Bisch, Paulo Ricardo Batista, Letícia Miranda Santos Lery

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 90:1655-1668

Klebsiella pneumoniae is an opportunistic pathogen, which concerns public health systems worldwide, as multiple antibiotic-resistant strains are frequent. One of its pathogenicity factors is the Type VI Secretion System (T6SS), a macromolecular compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951de943f593728eeb991b8921afdb63
https://doi.org/10.1002/prot.26344

Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

Autor: Laurent J. Catoire, Sonia Cantel, Marjorie Damian, Jean-Alain Fehrentz, Maxime Louet, Antoniel As Gomes, Jean-Louis Banères, Sophie Mary, Paulo R. Batista, David Perahia, Paulo Mascarello Bisch, Mauricio Gs Costa, Khoubaib Ben Haj Salah, Céline M'Kadmi, Marina Casiraghi, Pedro Renault, Severine Denoyelle, Nicolas Floquet

Publikováno v: eLife
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.63201⟩
eLife, Vol 10 (2021)
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/elife.63201⟩

International audience; There is increasing support for water molecules playing a role in signal propagation through G protein-coupled receptors (GPCRs). However, exploration of the hydration features of GPCRs is still in its infancy. Here, we combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7699a75687941d10e1c426d2dcfb4bfe
http://europepmc.org/articles/PMC8416020

A reaction-diffusion network model predicts a dual role of Cactus/IκB to regulate Dorsal/NFκB nuclear translocation in Drosophila

Autor: Helena Araujo, Claudio D. T. Barros, Maira Arruda Cardoso, Paulo Mascarello Bisch, Francisco J. P. Lopes

Publikováno v: PLoS Computational Biology, Vol 17, Iss 5, p e1009040 (2021)
PLoS Computational Biology

Dorsal-ventral patterning of the Drosophila embryo depends on the NFκB superfamily transcription factor Dorsal (Dl). Toll receptor activation signals for degradation of the IκB inhibitor Cactus (Cact), leading to a ventral-to-dorsal nuclear Dl grad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff24d227599f2b83d7eb70712000cf1
https://doaj.org/article/c4f725b58b054c42b40ba96f0a984358