Zobrazeno 1 - 10
of 964
pro vyhledávání: '"PAUL GREENGARD"'
Autor:
Lucile Marion-Poll, Jean-Pierre Roussarie, Lieng Taing, Cloelia Dard-Dascot, Nicolas Servant, Yan Jaszczyszyn, Emmanuelle Jordi, Eskeatnaf Mulugeta, Denis Hervé, Déborah Bourc’his, Paul Greengard, Claude Thermes, Jean-Antoine Girault
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Striatal projection neurons expressing the D1 or D2 dopamine receptors are probed for translating mRNAs and DNA modifications, identifying differential methylation signatures between the cell types and genome-wide hydroxymethylation asymmetry between
Externí odkaz:
https://doaj.org/article/fbba041371de4c2e84d3e2b2867fbc3e
Autor:
Jose Henrique Ledo, Ran Zhang, Luka Mesin, Diego Mourão-Sá, Estefania P Azevedo, Hernandez Moura Silva, Olga G Troyanskaya, Victor Bustos, Paul Greengard
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247680 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0237773.].
Externí odkaz:
https://doaj.org/article/21d1f6bb95a349debe03d947808fbc31
Autor:
Jose Henrique Ledo, Ran Zhang, Luka Mesin, Diego Mourão-Sá, Estefania P Azevedo, Olga G Troyanskaya, Victor Bustos, Paul Greengard
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237773 (2020)
Microglial cells play a key role in brain homeostasis from development to adulthood. Here we show the involvement of a site-specific phosphorylation of Presenilin 1 (PS1) in microglial development. Profiles of microglia-specific transcripts in differ
Externí odkaz:
https://doaj.org/article/d4ab345b9e074e9b86f224c51554c19b
Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements
Autor:
Leila Pirhaji, Pamela Milani, Simona Dalin, Brook T. Wassie, Denise E. Dunn, Robert J. Fenster, Julian Avila-Pacheco, Paul Greengard, Clary B. Clish, Myriam Heiman, Donald C. Lo, Ernest Fraenkel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Identifying gene subsets affecting disease phenotypes from transcriptome data is challenge. Here, the authors develop a method that combines transcriptional data with disease ordinal clinical measurements to discover a sphingolipid metabolism regulat
Externí odkaz:
https://doaj.org/article/ec0af8273fb342fcbf9ccadba0111a01
Autor:
Thomas Liebmann, Nicolas Renier, Karima Bettayeb, Paul Greengard, Marc Tessier-Lavigne, Marc Flajolet
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 1138-1152 (2016)
Amyloidosis is a major problem in over one hundred diseases, including Alzheimer’s disease (AD). Using the iDISCO visualization method involving targeted molecular labeling, tissue clearing, and light-sheet microscopy, we studied plaque formation i
Externí odkaz:
https://doaj.org/article/81cb50cfb7834fee86952e0d56ff1f3f
Autor:
Veronica Musante, Lu Li, Jean Kanyo, Tukiet T Lam, Christopher M Colangelo, Shuk Kei Cheng, A Harrison Brody, Paul Greengard, Nicolas Le Novère, Angus C Nairn
Publikováno v:
eLife, Vol 6 (2017)
ARPP-16, ARPP-19, and ENSA are inhibitors of protein phosphatase PP2A. ARPP-19 and ENSA phosphorylated by Greatwall kinase inhibit PP2A during mitosis. ARPP-16 is expressed in striatal neurons where basal phosphorylation by MAST3 kinase inhibits PP2A
Externí odkaz:
https://doaj.org/article/1c6cbe02d5e743ca833ba86d9c17d590
Autor:
Chad M Estep, Daniel J Galtieri, Enrico Zampese, Joshua A Goldberg, Lars Brichta, Paul Greengard, D James Surmeier
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0169044 (2016)
Dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) are richly innervated by GABAergic neurons. The postsynaptic effects of GABA on SNc DA neurons are mediated by a mixture of GABAA and GABAB receptors. Although activation of GABAA
Externí odkaz:
https://doaj.org/article/32b2a9924b564f8d92964d5ea3a9eac0
Publikováno v:
Communicative & Integrative Biology, Vol 3, Iss 6, Pp 487-490 (2010)
Norbin, a neurite-outgrowth promoting protein, has been found to interact with and regulate several membrane proteins, including metabotropic glutamate receptor 5 (mGluR5). The disruption of both Norbin alleles leads to early embryonic death between
Externí odkaz:
https://doaj.org/article/d7784a97fd3f4928ae7f9b82dc0d6b22
Autor:
Claudia G. Almeida, Davide Tampellini, Reisuke H. Takahashi, Paul Greengard, Michael T. Lin, Eric M. Snyder, Gunnar K. Gouras
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 187-198 (2005)
Synaptic dysfunction is increasingly viewed as an early manifestation of Alzheimer's disease (AD), but the cellular mechanism by which β-amyloid (Aβ) may affect synapses remains unclear. Since cultured neurons derived from APP mutant transgenic mic
Externí odkaz:
https://doaj.org/article/fe6d6879e48d4dce974c0d4687b5270c
Autor:
Jian Xu, Manavi Chatterjee, Tyler D Baguley, Jonathan Brouillette, Pradeep Kurup, Debolina Ghosh, Jean Kanyo, Yang Zhang, Kathleen Seyb, Chimezie Ononenyi, Ethan Foscue, George M Anderson, Jodi Gresack, Gregory D Cuny, Marcie A Glicksman, Paul Greengard, TuKiet T Lam, Lutz Tautz, Angus C Nairn, Jonathan A Ellman, Paul J Lombroso
Publikováno v:
PLoS Biology, Vol 12, Iss 8, p e1001923 (2014)
STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking, as well as ERK1/2, p38
Externí odkaz:
https://doaj.org/article/464c724e9a9e498caf07c3427d02b23b