Zobrazeno 1 - 10
of 267
pro vyhledávání: '"PASMCs"'
Publikováno v:
Clinical and Experimental Hypertension, Vol 46, Iss 1 (2024)
ABSTRACTPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK
Externí odkaz:
https://doaj.org/article/266fb4cd90934032acb25f8111f469ee
Autor:
Yi-Chia Wu, Wei-Ting Wang, Ming-Chun Yang, Yu-Tsun Su, Jwu-Lai Yeh, Jong-Hau Hsu, Jiunn-Ren Wu
Publikováno v:
Biological Research, Vol 56, Iss 1, Pp 1-16 (2023)
Abstract Background Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) along with dysregulated glycolysis, is a pathognomonic feature of pulmonary arte
Externí odkaz:
https://doaj.org/article/cc7bb2c564ff45e18571fe0ff1d3f604
Publikováno v:
Immunity, Inflammation and Disease, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract Objective To explore the role of interleukin (IL)‐17 in connective tissue disease‐associated pulmonary arterial hypertension (CTD‐PAH) and to investigate its possible mechanism on pulmonary artery smooth muscle cells (PASMCs). Methods
Externí odkaz:
https://doaj.org/article/ffdd861fa0a0466fb172ee3077e73300
Autor:
Yiyang Zhang, Jun Wang, Meng Zhang, Xiaoyun Li, Fan Zhang, Manlin Zhou, Kun Yang, Weiji Chen, Haie Ding, Xiao Tan, Qian Zhang, Zilin Qiao
Publikováno v:
Animals, Vol 14, Iss 16, p 2422 (2024)
The aim of this study was to investigate the effects of hypoxia-induced phenotype, glucose metabolism, ROS levels, and the PDK1-mediated regulation of TGF-β/Smad signaling in yellow cattles, yaks, and those overexpressing PDK1 PASMCs using growth cu
Externí odkaz:
https://doaj.org/article/7f1950bf22c14444b81e599b6ba772a3
Autor:
Jing‐jing Zhou, Jian Yang, Li Li, Rui‐lin Quan, Xiao‐xi Chen, Yu‐ling Qian, Li Huang, Pei‐he Wang, Yue Li, Xian‐min Meng, Xi Chen, Qing Gu, Jian‐Guo He
Publikováno v:
ESC Heart Failure, Vol 9, Iss 5, Pp 3407-3417 (2022)
Abstract Aims Orchestrating the transition from reversible medial hypertrophy to irreversible plexiform lesions is crucial for pulmonary arterial hypertension related to congenital heart disease (CHD‐PAH). Transgelin is an actin‐binding protein t
Externí odkaz:
https://doaj.org/article/70999a62ebd2422f881e41f9ab73a17e
Autor:
Jingjing Zhou
Publikováno v:
ESC Heart Failure, Vol 9, Iss 5, Pp 3221-3231 (2022)
Abstract Aims Although considerable progress has been made in the diagnosis and treatment of congenital heart disease‐associated pulmonary heart hypertension (CHD‐PAH), the clinical prognosis and overall survival of patients with CHD‐PAH remain
Externí odkaz:
https://doaj.org/article/dbe08b4197f04ae8a48aaeaf5e8c37bd
Autor:
Yiyang Zhang, Manlin Zhou, Yuxin Liang, Rui Li, Lan Zhang, Shuwu Chen, Kun Yang, Haie Ding, Xiao Tan, Qian Zhang, Zilin Qiao
Publikováno v:
Animals, Vol 13, Iss 22, p 3450 (2023)
The aim of this study was to investigate the molecular mechanisms by which hypoxia affects the biological behavior of yak PASMCs, the changes in the histological structure of yak and cattle lungs, and the relationships and regulatory roles that exist
Externí odkaz:
https://doaj.org/article/3c04af591381420088ecb0502b2529f7
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Excessive proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) are critical factors leading to vascular remodeling in pulmonary hypertension (PH). This study aimed to explore the effect and potential mechanism of Plumula Nelum
Externí odkaz:
https://doaj.org/article/9fa3c13b6e554bf3b3b7d91f042ae91b
Autor:
Zhihong Xin, Junfu Wang, Susu Li, Chao Sun, Wan Jiang, Qian Xin, Jue Wang, Tonggnag Qi, Kailin Li, Zhaohua Zhang, Yun Luan
Publikováno v:
Clinical and Experimental Hypertension, Vol 44, Iss 2, Pp 175-180 (2022)
Pulmonary arterial hypertension (PAH) is a chronic disease characterized by a progressive elevation in mean pulmonary arterial pressure. This occurs due to abnormal remodeling of small peripheral lung vasculature resulting in progressive occlusion of
Externí odkaz:
https://doaj.org/article/d93c6bee50dc435ea571459a626dd8a2
Autor:
Xiaopei Cao, Xiaoyu Fang, Mingzhou Guo, Xiaochen Li, Yuanzhou He, Min Xie, Yongjian Xu, Xiansheng Liu
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Hypoxic pulmonary hypertension (PH) is a refractory pulmonary vascular remodeling disease, and the efficiency of current PH treatment strategies is unsatisfactory. Tribbles homolog 3 (TRB3), a member of the pseudokinase family, is
Externí odkaz:
https://doaj.org/article/cd5268d388f74d458e3317039598cf1f